Total energy expenditure as assessed by doubly labeled water and all-cause mortality in a cohort of postmenopausal women.
all-cause mortality
body weight
doubly labeled water
energy expenditure
energy intake
Journal
The American journal of clinical nutrition
ISSN: 1938-3207
Titre abrégé: Am J Clin Nutr
Pays: United States
ID NLM: 0376027
Informations de publication
Date de publication:
05 2023
05 2023
Historique:
received:
12
09
2022
revised:
22
02
2023
accepted:
24
02
2023
pmc-release:
06
03
2024
medline:
5
5
2023
pubmed:
9
3
2023
entrez:
8
3
2023
Statut:
ppublish
Résumé
The association of TEE with all-cause mortality is uncertain, as is the dependence of this association on age. To examine the association between TEE and all-cause mortality, and its age interaction, in a Women's Health Initiative (WHI) cohort of postmenopausal United States women (1992-present). A cohort of 1131 WHI participants having DLW TEE assessment of ∼10.0 y (median) following WHI enrollment with ∼13.7 y (median) of subsequent follow-up, was used to study the EE associations with all-cause mortality. To enhance the comparability of TEE and total EI, key analyses excluded participants having >5% weight change between WHI enrollment and DLW assessment. The influence of participant age on mortality associations was examined, as was the ability of concurrent and earlier weight and height measurements to explain the results. There were 308 deaths following the TEE assessment through 2021. TEE was unrelated to overall mortality (P = 0.83) in this cohort of generally healthy, older (mean 71 y at TEE assessment) United States women. However, this potential association varied with age (P = 0.003). Higher TEE was associated with a higher mortality rate at the age of 60 y and a lower mortality rate at the age of 80 y. Within the weight-stable subset (532 participants, 129 deaths), TEE was weakly positively related to overall mortality (P = 0.08). This association also varied with age (P = 0.03), with mortality HRs (95% CIs) for a 20% increment in TEE of 2.33 (1.24, 4.36) at the age of 60 y, 1.49 (1.10, 2.02) at 70 y of age, and 0.96 (0.66, 1.38) at 80 y of age. This pattern remained, although was somewhat attenuated, following control for baseline weight and weight changes between WHI enrollment and TEE assessment. Higher EE is associated with higher all-cause mortality among younger postmenopausal women, only partially explained by weight and weight change. This study is registered with clinicaltrials.gov identifier: NCT00000611.
Sections du résumé
BACKGROUND
The association of TEE with all-cause mortality is uncertain, as is the dependence of this association on age.
OBJECTIVES
To examine the association between TEE and all-cause mortality, and its age interaction, in a Women's Health Initiative (WHI) cohort of postmenopausal United States women (1992-present).
METHODS
A cohort of 1131 WHI participants having DLW TEE assessment of ∼10.0 y (median) following WHI enrollment with ∼13.7 y (median) of subsequent follow-up, was used to study the EE associations with all-cause mortality. To enhance the comparability of TEE and total EI, key analyses excluded participants having >5% weight change between WHI enrollment and DLW assessment. The influence of participant age on mortality associations was examined, as was the ability of concurrent and earlier weight and height measurements to explain the results.
RESULTS
There were 308 deaths following the TEE assessment through 2021. TEE was unrelated to overall mortality (P = 0.83) in this cohort of generally healthy, older (mean 71 y at TEE assessment) United States women. However, this potential association varied with age (P = 0.003). Higher TEE was associated with a higher mortality rate at the age of 60 y and a lower mortality rate at the age of 80 y. Within the weight-stable subset (532 participants, 129 deaths), TEE was weakly positively related to overall mortality (P = 0.08). This association also varied with age (P = 0.03), with mortality HRs (95% CIs) for a 20% increment in TEE of 2.33 (1.24, 4.36) at the age of 60 y, 1.49 (1.10, 2.02) at 70 y of age, and 0.96 (0.66, 1.38) at 80 y of age. This pattern remained, although was somewhat attenuated, following control for baseline weight and weight changes between WHI enrollment and TEE assessment.
CONCLUSIONS
Higher EE is associated with higher all-cause mortality among younger postmenopausal women, only partially explained by weight and weight change. This study is registered with clinicaltrials.gov identifier: NCT00000611.
Identifiants
pubmed: 36889672
pii: S0002-9165(23)39748-X
doi: 10.1016/j.ajcnut.2023.02.023
pmc: PMC10273089
pii:
doi:
Substances chimiques
Water
059QF0KO0R
Banques de données
ClinicalTrials.gov
['NCT00000611']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
955-963Subventions
Organisme : NIDA NIH HHS
ID : HHSN271201000004C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201000001C
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA119171
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201000003C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201000004C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201000046C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201000002C
Pays : United States
Informations de copyright
Copyright © 2023 American Society for Nutrition. All rights reserved.
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