[Mechanisms of Psychological Pain].

This article first reviews some methods for measuring psychological pain, as a subjective sensation, and outlines its neural mechanisms. Particularly, the involvement of the neural basis of the salience network, which consists of the insula and cingulate cortex, is described focusing on its relation to interoception. Next, we focus on the disease concept of psychological pain as a pathological condition, review some studies on somatic symptom disorder and related disorders, and discuss some possible methods of pain and future research directions.