Functional association between telomeres, oxidation and mitochondria.
antioxidants
epigenetics (DNA methylation)
inositol
male infertility
mitochondria
reactive oxygen species (ROS)
sperm telomere length
telomere
Journal
Frontiers in reproductive health
ISSN: 2673-3153
Titre abrégé: Front Reprod Health
Pays: Switzerland
ID NLM: 9918230899006676
Informations de publication
Date de publication:
2023
2023
Historique:
received:
24
11
2022
accepted:
31
01
2023
entrez:
9
3
2023
pubmed:
10
3
2023
medline:
10
3
2023
Statut:
epublish
Résumé
Prior research has substantiated the vital role of telomeres in human fertility. Telomeres are prerequisites for maintaining the integrity of chromosomes by preventing the loss of genetic material following replication events. Little is known about the association between sperm telomere length and mitochondrial capacity involving its structure and functions. Mitochondria are structurally and functionally distinct organelles that are located on the spermatozoon's midpiece. Mitochondria produce adenosine triphosphate (ATP) through oxidative phosphorylation (OXPHOS), which is necessary for sperm motility and generate reactive oxygen species (ROS). While a moderate concentration of ROS is critical for egg-sperm fusion, and fertilization, excessive ROS generation is primarily related to telomere shortening, sperm DNA fragmentation, and alterations in the methylation pattern leading to male infertility. This review aims to highlight the functional connection between mitochondria biogenesis and telomere length in male infertility, as mitochondrial lesions have a damaging impact on telomere length, leading both to telomere lengthening and reprogramming of mitochondrial biosynthesis. Furthermore, it aims to shed light on how both inositol and antioxidants can positively affect male fertility.
Identifiants
pubmed: 36890798
doi: 10.3389/frph.2023.1107215
pmc: PMC9986632
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1107215Informations de copyright
© 2023 Moustakli, Zikopoulos, Sakaloglou, Bouba, Sofikitis and Georgiou.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Hum Reprod. 2006 Apr;21(4):986-93
pubmed: 16361286
Hum Reprod. 1999 Dec;14(12):3041-7
pubmed: 10601094
Front Genet. 2021 Jan 21;11:630186
pubmed: 33552142
Reprod Biomed Online. 2019 Apr;38(4):579-587
pubmed: 30777668
Clin Interv Aging. 2018 Apr 26;13:757-772
pubmed: 29731617
J Physiol Pharmacol. 2018 Jun;69(3):
pubmed: 30149371
J Dev Biol. 2021 Nov 13;9(4):
pubmed: 34842724
J Gerontol. 1956 Jul;11(3):298-300
pubmed: 13332224
BJU Int. 2008 Jun;101(12):1547-52
pubmed: 18294306
Br J Cancer. 2006 Jan 30;94(2):179-83
pubmed: 16404435
BMC Biol. 2015 Oct 29;13:89
pubmed: 26515107
Lancet. 2007 Jan 13;369(9556):107-14
pubmed: 17223473
Cell. 2013 Jun 6;153(6):1194-217
pubmed: 23746838
Arab J Urol. 2018 Feb 01;16(1):87-95
pubmed: 29713539
Circulation. 2009 Dec 15;120(24):2438-47
pubmed: 19948976
Mol Hum Reprod. 2013 Aug;19(8):510-8
pubmed: 23519357
Andrologia. 2021 Nov;53(10):e14204
pubmed: 34369610
Antioxidants (Basel). 2022 Feb 02;11(2):
pubmed: 35204189
Biochem Biophys Res Commun. 2016 Sep 23;478(3):1198-204
pubmed: 27545609
Exp Gerontol. 2007 Jul;42(7):575-81
pubmed: 17482404
Nature. 1981 Apr 9;290(5806):457-65
pubmed: 7219534
Front Plant Sci. 2016 Jun 28;7:851
pubmed: 27446102
Curr Opin Clin Nutr Metab Care. 2011 Jan;14(1):28-34
pubmed: 21102320
Clin Chim Acta. 2009 May;403(1-2):139-41
pubmed: 19217888
Fertil Steril. 2014 Dec;102(6):1518-27
pubmed: 25458618
Cancer Epidemiol Biomarkers Prev. 2007 Apr;16(4):815-9
pubmed: 17416776
Biodemography Soc Biol. 2020 Jan-Mar;65(1):73-87
pubmed: 32065536
J Natl Cancer Inst. 2003 Aug 20;95(16):1211-8
pubmed: 12928346
Circ Res. 2016 Mar 4;118(5):856-66
pubmed: 26699654
Kidney Int. 2015 Jul;88(1):85-94
pubmed: 25760322
Ann Anat. 2010 Sep 20;192(5):284-91
pubmed: 20732797
Antioxidants (Basel). 2019 Apr 05;8(4):
pubmed: 30959797
Exp Neurobiol. 2019 Dec 31;28(6):643-657
pubmed: 31902153
J Hum Reprod Sci. 2019 Jan-Mar;12(1):4-18
pubmed: 31007461
Antioxidants (Basel). 2021 May 17;10(5):
pubmed: 34067882
Arab J Urol. 2018 Jan 02;16(1):113-124
pubmed: 29713542
Vet Clin North Am Small Anim Pract. 2008 Jan;38(1):137-55, vi
pubmed: 18249246
PLoS One. 2013;8(1):e52989
pubmed: 23326372
Hum Reprod Update. 2019 Nov 5;25(6):733-757
pubmed: 31665451
Am J Ther. 2011 Nov;18(6):e209-26
pubmed: 20228673
Free Radic Biol Med. 2013 Jul;60:1-4
pubmed: 23434764
Annu Rev Genet. 2005;39:359-407
pubmed: 16285865
Mol Genet Metab. 2000 Sep-Oct;71(1-2):32-42
pubmed: 11001793
Mol Hum Reprod. 2012 Nov;18(11):517-22
pubmed: 22782639
Hum Reprod Update. 2021 Jun 22;27(4):697-719
pubmed: 33555313
FEBS Lett. 1999 Apr 1;448(1):4-8
pubmed: 10217398
Am J Mens Health. 2022 Sep-Oct;16(5):15579883221119931
pubmed: 36121249
World J Mens Health. 2014 Apr;32(1):1-17
pubmed: 24872947
World J Mens Health. 2021 Apr;39(2):233-290
pubmed: 33474843
Fertil Steril. 1994 Aug;62(2):376-86
pubmed: 8034088
Stem Cell Rev Rep. 2022 Oct;18(7):2315-2327
pubmed: 35460064
Diabetes Care. 2006 Feb;29(2):283-9
pubmed: 16443874
Aging Dis. 2015 Mar 10;6(2):109-20
pubmed: 25821639
Mol Neurodegener. 2017 Nov 13;12(1):84
pubmed: 29132391
Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16374-8
pubmed: 16258070
Arab J Urol. 2018 Feb 13;16(1):10-20
pubmed: 29713532
Andrologia. 2020 Jun;52(5):e13546
pubmed: 32189393
Asian J Androl. 2019 Nov-Dec;21(6):570-576
pubmed: 31031333
Cell. 1999 May 14;97(4):527-38
pubmed: 10338216
Andrologia. 2018 Mar;50(2):
pubmed: 28699197
Int J Fertil Steril. 2020 Apr;14(1):51-56
pubmed: 32112636
Nat Rev Genet. 2010 May;11(5):319-30
pubmed: 20351727
Mech Ageing Dev. 2019 Jan;177:37-45
pubmed: 29604323
Sci Rep. 2019 Mar 13;9(1):4336
pubmed: 30867501
Eur J Clin Invest. 2021 Oct;51(10):e13637
pubmed: 34107063
Antioxid Redox Signal. 2012 Aug 1;17(3):513-9
pubmed: 22324369
Cold Spring Harb Perspect Med. 2016 Apr 01;6(4):a026120
pubmed: 27037419
Arch Gynecol Obstet. 2013 Apr;287(4):803-7
pubmed: 23179801
Biomed Rep. 2016 May;4(5):519-522
pubmed: 27123241
Philos Trans R Soc Lond B Biol Sci. 2004 Jan 29;359(1441):109-21
pubmed: 15065663
Andrologia. 2019 Feb;51(1):e13162
pubmed: 30259539
Oxid Med Cell Longev. 2013;2013:956792
pubmed: 23738047
EPMA J. 2021 Mar 4;12(1):27-40
pubmed: 33686350
Aging Cell. 2010 Aug;9(4):607-15
pubmed: 20560902
Int J Cancer. 2009 Apr 1;124(7):1637-43
pubmed: 19089916
Biochem J. 2009 Jan 1;417(1):1-13
pubmed: 19061483
Cent European J Urol. 2013;66(1):60-7
pubmed: 24578993
J Cell Physiol. 2014 Oct;229(10):1323-9
pubmed: 24374808
Lancet. 2003 Feb 1;361(9355):393-5
pubmed: 12573379
Int J Mol Sci. 2017 Aug 04;18(8):
pubmed: 28777293
Lancet. 2005 Aug 20-26;366(9486):662-4
pubmed: 16112303
Am J Epidemiol. 2007 Jan 1;165(1):14-21
pubmed: 17043079
Osteoporos Int. 2007 Sep;18(9):1203-10
pubmed: 17347788
Carcinogenesis. 2010 Feb;31(2):216-21
pubmed: 19892797
EMBO J. 1997 Oct 1;16(19):6018-33
pubmed: 9312059
Biol Open. 2012 May 15;1(5):446-57
pubmed: 23213436
Antioxidants (Basel). 2020 Sep 29;9(10):
pubmed: 33003362
Reprod Med Biol. 2020 Oct 18;20(1):41-52
pubmed: 33488282
Biol Reprod. 2015 Feb;92(2):53
pubmed: 25568305
Int J Mol Sci. 2019 Dec 19;21(1):
pubmed: 31861522
Hum Reprod. 2016 Jun;31(6):1158-63
pubmed: 27052502
PLoS Genet. 2008 Feb;4(2):e37
pubmed: 18282113
Antioxidants (Basel). 2020 Jan 23;9(2):
pubmed: 31979208
Mol Biol Cell. 2006 Apr;17(4):1686-96
pubmed: 16436506
Cells. 2020 Nov 23;9(11):
pubmed: 33238415
Am J Clin Nutr. 2010 May;91(5):1273-80
pubmed: 20219960
Biochem Biophys Res Commun. 2000 Dec 9;279(1):213-8
pubmed: 11112441
Antioxidants (Basel). 2021 Apr 12;10(4):
pubmed: 33921485
Front Cell Dev Biol. 2019 Nov 06;7:274
pubmed: 31781563
Br J Dermatol. 2013 Jul;169 Suppl 2:1-8
pubmed: 23786614
Proc Natl Acad Sci U S A. 1998 May 12;95(10):5607-10
pubmed: 9576930
J Clin Endocrinol Metab. 2008 Aug;93(8):3199-207
pubmed: 18492763
Oxid Med Cell Longev. 2017;2017:4535194
pubmed: 28744337
J Cell Sci. 2008 Apr 1;121(Pt 7):1046-53
pubmed: 18334557
Cell Tissue Res. 2016 Jan;363(1):185-194
pubmed: 26183721
Mol Biol Cell. 2001 Jul;12(7):2023-30
pubmed: 11452000
Hum Mol Genet. 2007 Dec 15;16(24):3097-102
pubmed: 17881651
Andrologia. 2021 Feb;53(1):e13644
pubmed: 32427374
Reproduction. 2022 Oct 26;164(6):F95-F108
pubmed: 36111646
Andrologia. 2014 Feb;46(1):17-23
pubmed: 23126684
PLoS One. 2008;3(10):e3520
pubmed: 18949037
Differentiation. 2018 Jan - Feb;99:21-27
pubmed: 29274896
Andrology. 2020 May;8(3):583-593
pubmed: 31769603
J Cell Mol Med. 2017 Jan;21(1):121-129
pubmed: 27558591
J Am Coll Cardiol. 2007 Apr 3;49(13):1459-64
pubmed: 17397675
Aging Cell. 2005 Apr;4(2):97-101
pubmed: 15771613
Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17312-5
pubmed: 15574496
Cell. 2014 May 8;157(4):897-909
pubmed: 24813612
Genes (Basel). 2019 Jul 12;10(7):
pubmed: 31336906
Biol Reprod. 2000 Aug;63(2):591-8
pubmed: 10906069
Front Cardiovasc Med. 2019 Apr 02;6:31
pubmed: 31001540
Circ Res. 2015 Jan 30;116(3):480-8
pubmed: 25634971
JAMA. 2010 Jan 20;303(3):250-7
pubmed: 20085953
Fertil Steril. 2006 Oct;86(4):878-85
pubmed: 17027357
J Assist Reprod Genet. 2020 Oct;37(10):2581-2603
pubmed: 32767207
J Hum Reprod Sci. 2015 Oct-Dec;8(4):191-6
pubmed: 26752853
Microsc Res Tech. 2007 Aug;70(8):719-23
pubmed: 17457821
Environ Health. 2009 Sep 21;8:41
pubmed: 19772576
Biol Reprod. 1975 Jun;12(5):641-6
pubmed: 1220831
Eur Respir J. 2006 Mar;27(3):525-8
pubmed: 16507852
Nature. 2019 Jan;565(7741):659-663
pubmed: 30675059
Biol Reprod. 2014 Sep;91(3):77
pubmed: 25078685
Reprod Biomed Online. 2016 Sep;33(3):404-11
pubmed: 27396673
PLoS One. 2014 Oct 29;9(10):e110963
pubmed: 25354277
J Clin Invest. 2004 Dec;114(12):1752-61
pubmed: 15599400