Toxic effects of per- and polyfluoroalkyl substances on sperm: Epidemiological and experimental evidence.
male fecundity
per- and polyfluoroalkyl substances
reproductive toxicity
sperm
testosterone
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2023
2023
Historique:
received:
02
12
2022
accepted:
07
02
2023
entrez:
9
3
2023
pubmed:
10
3
2023
medline:
11
3
2023
Statut:
epublish
Résumé
As emerging organic contaminants, per- and polyfluoroalkyl substances (PFASs) have aroused worldwide concern due to their environmental persistence, ubiquitous presence, bioaccumulation, and potential toxicity. It has been demonstrated that PFASs can accumulate in human body and cause multiple adverse health outcomes. Notably, PFASs have been detected in the semen of human, posing a potential hazard to male fecundity. This article reviews the evidence about the toxic effects of exposure to PFASs on male reproduction, focusing on the sperm quality. Epidemiological studies showed that PFASs, such as perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS), were adversely associated with the semen parameters in humans, including sperm count, morphology and motility. Experimental results also confirmed that PFAS exposure led to testicular and epididymal damage, therefore impairing spermatogenesis and sperm quality. The mechanisms of reproductive toxicity of PFASs may be involved in blood-testosterone barrier destruction, testicular apoptosis, testosterone synthesis disorder, and membrane lipid composition alteration, oxidative stress and Ca
Identifiants
pubmed: 36891048
doi: 10.3389/fendo.2023.1114463
pmc: PMC9986484
doi:
Substances chimiques
Environmental Pollutants
0
Fluorocarbons
0
Testosterone
3XMK78S47O
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1114463Informations de copyright
Copyright © 2023 Sun, Wen, Wang, Deng, Zhang, Fu, Yuan and Zhang.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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