Vitamin A regulates tissue-specific organ remodeling in diet-induced obesity independent of mitochondrial function.
diet-induced obesity
kidney
liver
mitochondria
skeletal muscle
type 2 diabetes
vitamin A
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2023
2023
Historique:
received:
07
12
2022
accepted:
08
02
2023
entrez:
9
3
2023
pubmed:
10
3
2023
medline:
11
3
2023
Statut:
epublish
Résumé
Perturbed mitochondrial energetics and vitamin A (VitA) metabolism are associated with the pathogenesis of diet-induced obesity (DIO) and type 2 diabetes (T2D). To test the hypothesis that VitA regulates tissue-specific mitochondrial energetics and adverse organ remodeling in DIO, we utilized a murine model of impaired VitA availability and high fat diet (HFD) feeding. Mitochondrial respiratory capacity and organ remodeling were assessed in liver, skeletal muscle, and kidney tissue, which are organs affected by T2D-associated complications and are critical for the pathogenesis of T2D. In liver, VitA had no impact on maximal ADP-stimulated mitochondrial respiratory capacity (V The present study identifies an unexpected and tissue-specific role for VitA in DIO that regulates the pro-fibrotic transcriptional response and that results in organ damage independent of changes in mitochondrial energetics.
Sections du résumé
Background
Perturbed mitochondrial energetics and vitamin A (VitA) metabolism are associated with the pathogenesis of diet-induced obesity (DIO) and type 2 diabetes (T2D).
Methods
To test the hypothesis that VitA regulates tissue-specific mitochondrial energetics and adverse organ remodeling in DIO, we utilized a murine model of impaired VitA availability and high fat diet (HFD) feeding. Mitochondrial respiratory capacity and organ remodeling were assessed in liver, skeletal muscle, and kidney tissue, which are organs affected by T2D-associated complications and are critical for the pathogenesis of T2D.
Results
In liver, VitA had no impact on maximal ADP-stimulated mitochondrial respiratory capacity (V
Conclusion
The present study identifies an unexpected and tissue-specific role for VitA in DIO that regulates the pro-fibrotic transcriptional response and that results in organ damage independent of changes in mitochondrial energetics.
Identifiants
pubmed: 36891060
doi: 10.3389/fendo.2023.1118751
pmc: PMC9987331
doi:
Substances chimiques
Vitamin A
11103-57-4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1118751Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK056336
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK068437
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK122071
Pays : United States
Informations de copyright
Copyright © 2023 Shymotiuk, Froese, Werlein, Naasner, Szaroszyk, Kühnel, Jonigk, Blaner, Wende, Abel, Bauersachs and Riehle.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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