Creutzfeldt-Jakob Disease in a Patient with Previous COVID-19 Infection: "The Virus Caused the Derangement in My Brain".
COVID-19 infection
Cerebrospinal fluid total tau
Creutzfeldt-Jakob disease
SARS-CoV-2
prion disease
Journal
Journal of Alzheimer's disease reports
ISSN: 2542-4823
Titre abrégé: J Alzheimers Dis Rep
Pays: Netherlands
ID NLM: 101705500
Informations de publication
Date de publication:
2023
2023
Historique:
received:
30
11
2022
accepted:
11
01
2023
entrez:
9
3
2023
pubmed:
10
3
2023
medline:
10
3
2023
Statut:
epublish
Résumé
Recent studies have speculated a link between Creutzfeldt-Jakob disease (CJD) and COVID-19, following the description of CJD cases after COVID-19 infection. We report the case of a 71-year-old female patient who developed neuropsychiatric and neurological symptoms after COVID-19 infection and was later diagnosed with CJD. Cerebrospinal fluid (CSF) total tau levels were slightly increased. She resulted prion protein gene (PRNP) M129V heterozygous. We aim to emphasize the role of the polymorphism at codon 129 of PRNP gene on the clinical phenotype and duration of CJD, and the CSF total tau levels that likely correlate with the rate of disease progression.
Identifiants
pubmed: 36891254
doi: 10.3233/ADR-220095
pii: ADR220095
pmc: PMC9986709
doi:
Types de publication
Journal Article
Langues
eng
Pagination
129-134Informations de copyright
© 2023 – The authors. Published by IOS Press.
Déclaration de conflit d'intérêts
The authors declare that they have no conflict of interest.
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