Seborrheic keratosis.


Journal

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
ISSN: 1610-0387
Titre abrégé: J Dtsch Dermatol Ges
Pays: Germany
ID NLM: 101164708

Informations de publication

Date de publication:
03 2023
Historique:
received: 16 10 2022
accepted: 04 12 2022
pubmed: 10 3 2023
medline: 22 3 2023
entrez: 9 3 2023
Statut: ppublish

Résumé

Seborrheic keratosis (SK) is the most common benign epidermal tumor in clinical dermatological practice. This review summarizes current knowledge about the clinical and histological appearance, epidemiology, pathogenesis, and treatment of SK. There are different subtypes of SK based on clinical presentation and histologic findings. Several factors, including age, genetic predisposition, and possibly also exposure to ultraviolet radiation, are thought to contribute to the development of SK. The lesions can occur on all areas of the body except for the palms and soles, but the most common sites are the face and upper trunk. The diagnosis is usually made clinically, and in some cases by dermatoscopy or histology. Many patients prefer to have the lesions removed for cosmetic reasons although there is no medical indication. Treatment options include surgical therapy, laser therapy, electrocautery, cryotherapy, and topical drug therapy, which is currently in development. Treatment should be individualized depending on the clinical picture and patient preference.

Identifiants

pubmed: 36892019
doi: 10.1111/ddg.14984
doi:

Types de publication

Review Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

265-277

Informations de copyright

© 2023 The Authors. Journal der Deutschen Dermatologischen Gesellschaft published by John Wiley & Sons Ltd on behalf of Deutsche Dermatologische Gesellschaft.

Références

Hafner C, Vogt T. Seborrheic keratosis. J Dtsch Dermatol Ges. 2008; 6(8):664-677.
Greco MJ, Bhutta BS. Seborrheic Keratosis. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing, 2022.
Bickers DR, Lim HW, Margolis D, et al. The burden of skin diseases: 2004 a joint project of the American Academy of Dermatology Association and the Society for Investigative Dermatology. J Am Acad Dermatol. 2006; 55(3):490-500.
Yeatman JM, Kilkenny M, Marks R. The prevalence of seborrhoeic keratoses in an Australian population: does exposure to sunlight play a part in their frequency? Br J Dermatol. 1997;137(3):411-414.
Jackson JM, Alexis A, Berman B, et al. Current understanding of seborrheic keratosis: prevalence, etiology, clinical presentation, diagnosis, and management. J Drugs Dermatol. 2015;14(10):1119-1125.
Gulias-Cañizo R, Aranda-Rábago J, Rodríguez-Reyes AA. [Seborrheic keratosis of conjunctiva: a case report]. Arch Soc Esp Oftalmol. 2006; 81(4):217-219.
Kim JH, Bae HW, Lee KK, et al. Seborrheic keratosis of the conjunctiva: a case report. Korean J Ophthalmol. 2009; 23(4):306-308.
Heffernan MP, Khavari PA. Raindrop seborrheic keratoses: a distinctive pattern on the backs of elderly patients. Arch Dermatol. 1998;134(3):382-383.
Zhang RZ, Zhu WY. Seborrheic keratoses in five elderly patients: an appearance of raindrops and streams. Indian J Dermatol. 2011;56(4):432-434.
Stadler R, Arheilger B. Epidermale Tumoren. In: Cerroni L, Garbe C, Metze D et al. (editors): Histopathologie der Haut. Berlin, Heidelberg: Springer Verlag, 2016;557-597.
Xiao A, Muse ME, Ettefagh L. Dermatosis Papulosa Nigra. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing, 2022.
Plewig G, Ruzicka T, Kaufmann R. Braun-Falco's Dermatologie, Venerologie und Allergologie, 7. Auflage, Springer Verlag, Berlin, Heidelberg, 2018.
Safa G, Darrieux L. Leser-Trélat sign without internal malignancy. Case Rep Oncol. 2011;4(1):175-177.
Braun RP, Rabinovitz HS, Krischer J, et al. Dermoscopy of pigmented seborrheic keratosis: a morphological study. Arch Dermatol. 2002;138(12):1556-1560.
Papageorgiou V, Apalla Z, Sotiriou E, et al. The limitations of dermoscopy: false-positive and false-negative tumours. J Eur Acad Dermatol Venereol. 2018;32(6):879-888.
Takenouchi T. Key points in dermoscopic diagnosis of basal cell carcinoma and seborrheic keratosis in Japanese. J Dermatol. 2011;38(1):59-65.
Minagawa A. Dermoscopy-pathology relationship in seborrheic keratosis. J Dermatol. 2017;44(5):518-524.
Ferrara G, Argenziano G, Soyer HP, et al. Dermoscopic-pathologic correlation: an atlas of 15 cases. Clin Dermatol. 2002;20(3):228-235.
Şahin MT, Oztürkcan S, Ermertcan AT, Günes AT. A comparison of dermoscopic features among lentigo senilis/initial seborrheic keratosis, seborrheic keratosis, lentigo maligna and lentigo maligna melanoma on the face. J Dermatol. 2004;31(11):884-889.
Kitamura S, Hata H, Imafuku K, et al. Dermoscopic findings of irritated seborrheic keratosis. J Eur Acad Dermatol Venereol. 2016;30(10):e94-e96.
Shahriari N, Grant-Kels JM, Rabinovitz H, et al. Reflectance confocal microscopy: Diagnostic criteria of common benign and malignant neoplasms, dermoscopic and histopathologic correlates of key confocal criteria, and diagnostic algorithms. J Am Acad Dermatol. 2021;84(1):17-31.
Guo A, Chen J, Yang C, et al. The challenge of diagnosing seborrheic keratosis by reflectance confocal microscopy. Skin Res Technol. 2018;24(4):663-666.
Chen S, Xie F, Hao T, et al. Evaluation of ultrahigh-resolution optical coherence tomography for basal cell carcinoma, seborrheic keratosis, and nevus. Skin Res Technol. 2021;27(4):479-485.
Laimer M, Kraus L, Zelger B. Verrucous seborrheic keratosis with keratoacanthoma-like features, a pitfall in differential diagnosis. J Dtsch Dermatol Ges. 2015;13(9):911-913.
Wagner G, Back W, Sachse MM. Clear cell acanthoma. J Dtsch Dermatol Ges. 2021;19(1):31-36.
Han JS, Lee MW, Won CH, et al. A case of seborrheic keratosis with clear cell change. Int J Dermatol. 2014;53(8):e370-e372.
Fritsch P, Schwarz T. Neoplasien (Tumoren) und tumorähnliche Läsionen der Haut. In: Dermatologie Venerologie: Grundlagen. Klinik. Atlas. Berlin, Heidelberg: Springer Verlag, 2018:713-871.
Wollina U. Seborrheic keratoses - the most common benign skin tumor of humans. Clinical presentation and an update on pathogenesis and treatment options. Open Access Maced J of Med Sci. 2018;6(11):2270-2275.
Wollina U. Recent advances in managing and understanding seborrheic keratosis. F1000Res. 2019;8:F1000 Faculty Rev-1520.
Reiches AJ. Seborrheic keratoses; are they delayed hereditary nevi? AMA Arch Derm Syphilol. 1952;65(5):596-600.
Rongioletti F, Corbella L, Rebora A. 1988. Multiple familial seborrheic keratoses. Dermatologica. 1988;176(1):43-45.
Hafner C, Vogt T, Landthaler M, Müsebeck J. Somatic FGFR3 and PIK3CA mutations are present in familial seborrhoeic keratoses. Br J Dermatol. 2008;159(1):214-217.
Zhao YK, Lin YX, Luo RY, et al. Human papillomavirus (HPV) infection in seborrheic keratosis. Am J Dermatopathol. 1989;11(3):209-212.
Tardio JC, Bancalari E, Moreno A, Martin-Fragueiro LM. Genital seborrheic keratosis are human papillomavirus-related lesions. A linear array genotyping test study. Apmis. 2012;120(6):477-483.
Wu YH, Hsiao PF, Chen CK. Seborrheic keratosis with bowenoid transformation: the immunohistochemical features and its association with human papillomavirus infection. Am J Dermatopathol. 2015;37(6):462-468.
Memon AA, Tomenson JA, Bothwell J, Friedmann PS. Prevalence of solar damage and actinic keratosis in a Merseyside population. Br J Dermatol. 2000;142(6):1154-1159.
Engel A, Johnson ML, Haynes SG. Health effects of sunlight exposure in the United States. Results from the first National Health and Nutrition Examination Survey, 1971-1974. Arch Dermatol. 1988;124(1):72-79.
Kwon OS, Hwang EJ, Bae JH, et al. Seborrheic keratosis in the Korean males: causative role of sunlight. Photodermatol Photoimmunol Photomed. 2003;19(2):73-80.
Kennedy C, Bajdik CD, Willemze R, et al. The Influence of painful sunburns and lifetime sun exposure on the risk of actinic keratoses, seborrheic warts, melanocytic nevi, atypical nevi, and skin cancer. J Invest Dermatol. 2003;120(6):1087-1093.
Li YH, Chen G, Dong XP, Chen HD. Detection of epidermodysplasia verruciformis-associated human papillomavirus DNA in nongenital seborrhoeic keratosis. Br J Dermatol. 2004;151(5):1060-1065.
Gushi A, Kanekura T, Kanzaki T,Eizuru Y. Detection and sequences of human papillomavirus DNA in nongenital seborrhoeic keratosis of immunopotent individuals. J Dermatol Sci. 2003;31(2):143-149.
Tsambaos D, Monastirli A, Kapranos N, et al. Detection of human papillomavirus DNA in nongenital seborrhoeic keratoses. Arch Dermatol Res. 1995;287(6):612-615.
Lee ES, Whang MR, Kang WH. Absence of human papillomavirus DNA in nongenital seborrheic keratosis. J Korean Med Sci. 2001;16(5):619-622.
Kambiz KH, Kaveh D, Maede D, et al. Human papillomavirus deoxyribonucleic acid may not be detected in non-genital benign papillomatous skin lesions by polymerase chain reaction. Indian J Dermatol. 2014;59(4):334-338.
Logie A, Dunois-Larde C, Rosty C, et al. Activating mutations of the tyrosine kinase receptor FGFR3 are associated with benign skin tumors in mice and humans. Hum Mol Genet. 2005;14(9):1153-1160.
Lopez-Knowles E, Hernandez S, Malats N, et al. PIK3CA mutations are an early genetic alteration associated with FGFR3 mutations in superficial papillary bladder tumors. Cancer Res. 2006;66(15):7401-7404.
Hafner C, Di Martino E, Pitt E, et al. FGFR3 mutation affects cell growth, apoptosis and attachment in keratinocytes. Exp Cell Res. 2010;316(12):2008-2016.
Hafner C, Hafner H, Groesser L. Genetische Grundlagen seborrhoischer Keratosen und epidermaler Nävi. Der Pathologe. 2014;35(5):413-423.
Hafner C, Stoehr R, van Oers JM, et al. FGFR3 and PIK3CA mutations are involved in the molecular pathogenesis of solar lentigo. Br J Dermatol. 2009;160(3):546-551.
Groesser L, Herschberger E, Landthaler M, Hafner C. FGFR3, PIK3CA and RAS mutations in benign lichenoid keratosis. Br J Dermatol. 2012;166(4):784-788.
Hafner C, Landthaler M, Mentzel T, Vogt T. FGFR3 and PIK3CA mutations in stucco keratosis and dermatosis papulosa nigra. Br J Dermatol. 2010;162(3):508-512.
Hafner C, van Oers JMM, Hartmann A, et al. High frequency of FGFR3 mutations in adenoid seborrheic keratoses. J Invest Dermatol. 2006;126(11):2404-2407.
Georgieva IA, Mauerer A, Groesser L, et al. Low incidence of oncogenic EGFR, HRAS, and KRAS mutations in seborrheic keratosis. Am J Dermatopathol. 2014;36(8):635-642.
Hafner C, Toll A, Fernandes-Casado A, et al. Multiple oncogenic mutations and clonal relationship in spatially distinct benign human epidermal tumors. Proc Natl Acad Sci U S A. 2010;107(48):20780-20785.
Heidenreich B, Denisova E, Rachakonda S, et al. Genetic alterations in seborrheic keratoses. Oncotarget. 2017;8(22):36639-36649.
Neel VA, Todorova K, Wang J, et al. Sustained Akt activity is required to maintain cell viability in seborrheic keratosis, a benign epithelial tumor. J Invest Dermatol. 2016;136(3):696-705.
Pressemeldung Fa. DermBiont 2020. Available from: www.dermbiont.com [Last accessed November 11, 2022].
Mandinova A, Kolev V, Neel V, et al. A positive FGFR3/FOXN1 feedback loop underlies benign skin keratosis versus squamous cell carcinoma formation in humans. J Clin Invest. 2009;119(10):3127-3137.
Eckhart L, Lippens S, Tschachler E, Declercq W. Cell death by cornification. Biochim Biophys Acta. 2013;1833(12):3471-3480.
Weil M, Raff MC, Braga VM. Caspase activation in the terminal differentiation of human epidermal keratinocytes. Curr Biol. 1999;9(7):361-364.
Wood LD, Stucki JK, Hollenbeak CS, Miller JJ. Effectiveness of cryosurgery vs curettage in the treatment of seborrheic keratoses. JAMA Dermatol. 2013;149(1):108-109.
Gurel MS, Aral BB. Effectiveness of erbium:YAG laser and cryosurgery in seborrheic keratoses: Randomized, prospective intraindividual comparison study. J Dermatolog Treat. 2015;26(5):477-480.
Zaresharifi S, Robati RM, Dadkhahfar S, et al. Efficacy and safety of cryotherapy, electrodesiccation, CO2 laser, and Er:YAG laser in the treatment of seborrheic keratosis. Dermatol Ther. 2021;34(5):e15083
Culbertson GR. 532-nm diode laser treatment of seborrheic keratoses with color enhancement. Dermatol Surg. 2008;34(4):525-528;discussion 528.
Aktas H, Ergin C, Keseroglu HÖ. Diclofenac gel may be a new treatment option for seborrheic keratosis. Indian Dermatol Online J. 2016;7(3):211-212.
Herron MD,Bowen AR, Krueger GG. Seborrheic keratoses: a study comparing the standard cryosurgery with topical calcipotriene, topical tazarotene, and topical imiquimod. Int J Dermatol. 2004;43(4):300-302.
Mitsuhashi Y. [New aspects on vitamin D3 ointment; treatment of senile warts with topical application of active forms of vitamin D3]. Clin Calcium. 2004;14(10):141-144.
Smith SR, Xu S, Estes E, Shanler SD. Anatomic site-specific treatment response with 40% hydrogen peroxide (w/w) topical formulation for raised seborrheic keratoses: pooled analysis of data from two phase 3 studies. J Drugs Dermatol. 2018;17(10):1092-1098.
Baumann LS, Blauvelt A, Draelos ZD, et al. Safety and efficacy of hydrogen peroxide topical solution, 40% (w/w), in patients with seborrheic keratoses: Results from 2 identical, randomized, double-blind, placebo-controlled, phase 3 studies (A-101-SEBK-301/302). J Am Acad Dermatol. 2018;79(5):869-877.
Reyes M. 2017. Center for drug evaluation and research. Clinical review. Application number: 209305Orig1s000. Accessed August 3, 2019.
Campione E, Cosio T, Di Prete M, et al. Effectiveness of a cosmetic device containing a combination of alpha- and beta-hydroxy acids, urea, and thuja for the treatment of seborrheic keratoses. J Cosmet Dermatol. 2022;21(5):2113-2119.
Cuevas P, Angulo J, Salgüero I, Gimenez-Gallego G. Clearance of seborrhoeic keratoses with topical dobesilate. BMJ Case Rep. 2012;2012:bcr0120125628.
Levy-Nissenbaum E, Thio HB, Burstein P, Thaci D. Seborrhoeic keratosis removal in a multicentre phase I/II clinical trial using a novel topical formulation (BL-5010). Br J Dermatol. 2015;173(1):247-249.
Asagami C, Muto M, Hirota T, et al. Anti-tumor effects of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) in seborrheic keratosis. J Investig Dermatol Symp Proc. 1996;1(1):94-96.
Available from: https://www.pcds.org.uk/clinical-guidance/dermatosis-papulosa-nigra [Last accessed November 11, 2022].

Auteurs

Sara Barthelmann (S)

Skin clinic, Mainz University Hospital.

Florian Butsch (F)

Skin clinic, Mainz University Hospital.

Berenice M Lang (BM)

Skin clinic, Mainz University Hospital.

Henner Stege (H)

Skin clinic, Mainz University Hospital.

Bernd Großmann (B)

MVZ Dermatology Clinic, Koblenz.

Hadrian Schepler (H)

Skin clinic, Mainz University Hospital.
MVZ Dermatology Clinic, Koblenz.

Stephan Grabbe (S)

Skin clinic, Mainz University Hospital.

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