Choroid plexus-targeted NKCC1 overexpression to treat post-hemorrhagic hydrocephalus.

Humans Choroid Plexus Hydrocephalus / therapy Cerebral Hemorrhage / complications
Cerebrospinal fluid NKCC1 adeno-associated virus choroid plexus epithelial cells gene therapy hydrocephalus intraventricular hemorrhage ventricles

Journal

Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320

Informations de publication

Date de publication:
17 05 2023
Historique:
received: 16 08 2022
revised: 17 01 2023
accepted: 13 02 2023
pmc-release: 17 05 2024
medline: 22 5 2023
pubmed: 10 3 2023
entrez: 9 3 2023
Statut: ppublish

Résumé

Post-hemorrhagic hydrocephalus (PHH) refers to a life-threatening accumulation of cerebrospinal fluid (CSF) that occurs following intraventricular hemorrhage (IVH). An incomplete understanding of this variably progressive condition has hampered the development of new therapies beyond serial neurosurgical interventions. Here, we show a key role for the bidirectional Na-K-Cl cotransporter, NKCC1, in the choroid plexus (ChP) to mitigate PHH. Mimicking IVH with intraventricular blood led to increased CSF [K

Identifiants

DOI: 10.1016/j.neuron.2023.02.020 PMID: 36893755 PMC: PMC10198810
pubmed: 36893755
pii: S0896-6273(23)00124-1
doi: 10.1016/j.neuron.2023.02.020
pmc: PMC10198810
mid: NIHMS1876892
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1591-1608.e4

Subventions

Organisme : NCCIH NIH HHS
ID : DP1 AT010971
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS088566
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS129823
Pays : United States
Organisme : NIDA NIH HHS
ID : RF1 DA048790
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests M.K.L., R.M.F., C.S., and H.X. are co-inventors on a provisional patent application related to this manuscript.

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Auteurs

Cameron Sadegh (C)

Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

Huixin Xu (H)

Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.

Jason Sutin (J)

Fetal-Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Benoit Fatou (B)

Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.

Suhasini Gupta (S)

Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.

Aja Pragana (A)

Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.

Milo Taylor (M)

Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA; Harvard College, Harvard University, Cambridge, MA 02138, USA.

Peter N Kalugin (PN)

Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA; Harvard/MIT MD-PhD Program, Harvard Medical School, Boston, MA 02115, USA; Graduate Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA.

Miriam E Zawadzki (ME)

Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA; Harvard/MIT MD-PhD Program, Harvard Medical School, Boston, MA 02115, USA; Graduate Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115, USA.

Osama Alturkistani (O)

Cellular Imaging Core, Boston Children's Hospital, Boston, MA 02115, USA.

Frederick B Shipley (FB)

Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA; Graduate Program in Biophysics, Harvard University, Cambridge, MA 02138, USA.

Neil Dani (N)

Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.

Ryann M Fame (RM)

Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.

Zainab Wurie (Z)

Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.

Pratik Talati (P)

Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

Riana L Schleicher (RL)

Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

Eric M Klein (EM)

Carney Institute for Brain Science, Brown University, Providence, RI 02912, USA.

Yong Zhang (Y)

Pulmonary and Critical Care Medicine, Department of Medicine, Washington University, St. Louis, MO, 63110, USA.

Michael J Holtzman (MJ)

Pulmonary and Critical Care Medicine, Department of Medicine, Washington University, St. Louis, MO, 63110, USA.

Christopher I Moore (CI)

Carney Institute for Brain Science, Brown University, Providence, RI 02912, USA.

Pei-Yi Lin (PY)

Fetal-Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Aman B Patel (AB)

Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

Benjamin C Warf (BC)

Department of Neurosurgery, Boston Children's Hospital, Boston, MA 02115, USA.

W Taylor Kimberly (WT)

Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

Hanno Steen (H)

Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA; Precision Vaccines Program, Boston Children's Hospital, Boston, MA 02115, USA.

Mark L Andermann (ML)

Graduate Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA; Graduate Program in Biophysics, Harvard University, Cambridge, MA 02138, USA; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

Maria K Lehtinen (MK)

Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA; Graduate Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA; Graduate Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115, USA; Graduate Program in Biophysics, Harvard University, Cambridge, MA 02138, USA. Electronic address: maria.lehtinen@childrens.harvard.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Choroid plexus-targeted NKCC1 overexpression...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Ventricules cérébraux › Plexus choroïde › Choroid plexus-targeted NKCC1 overexpression...
questionsmedicales.fr › Maladies du système nerveux › Maladies du système nerveux central › Encéphalopathies › Hydrocéphalie › Choroid plexus-targeted NKCC1 overexpression...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Hémorragie › Hémorragies intracrâniennes › Hémorragie cérébrale › Choroid plexus-targeted NKCC1 overexpression...