The Relationship Between Diet, Gut Microbiota, and Serum Metabolome of South Asian Infants at 1 Year.

Adult Pregnancy Female Humans Infant Gastrointestinal Microbiome Cohort Studies RNA, Ribosomal, 16S / genetics Feces / microbiology Canada Diet Metabolome
breastfeeding ethnicity gut microbiota infant diet serum metabolome

Journal

The Journal of nutrition
ISSN: 1541-6100
Titre abrégé: J Nutr
Pays: United States
ID NLM: 0404243

Informations de publication

Date de publication:
02 2023
Historique:
received: 24 10 2022
revised: 10 12 2022
accepted: 21 12 2022
entrez: 9 3 2023
pubmed: 10 3 2023
medline: 14 3 2023
Statut: ppublish

Résumé

Diet is known to affect the gut microbiota and the serum metabolome in adults, but this has not been fully explored in infants. Infancy is an important developmental period that may influence a person's long-term health. Infant development can be affected by diet, which also interacts with the developing gut microbiota. This study aimed to explore the associations between diet, the gut microbiota, and the serum metabolome of 1-y-old infants with the overarching goal of identifying serum biomarkers of diet and/or the gut microbiota. We derived dietary patterns of 1-y-old infants (n = 182) participating in the Canadian South Asian Birth Cohort (START) study. We compared gut microbiota α-diversity and β-diversity and taxa relative abundance from 16S rRNA gene profiles with dietary patterns (PERMANOVA, Envfit) and investigated diet-serum metabolite associations using a multivariate analysis (partial least squares-discriminant analysis) and univariate analysis (t test). We explored the effect of nondietary factors on diet-serum metabolite relationships by incorporating diet, the gut microbiota, and maternal, perinatal, and infant characteristics in a multivariable forward stepwise regression. We replicated this analysis in White European infants, from the CHILD Cohort Study (n = 81). A dietary pattern characterized by formula consumption and negatively associated with breastfeeding most strongly predicted variation in the gut microbiota (R Formula consumption and breastfeeding most strongly predicted the serum metabolites of 1-y-old infants, even when the gut microbiota, solid food consumption, and other covariates were considered.

Sections du résumé

BACKGROUND
Diet is known to affect the gut microbiota and the serum metabolome in adults, but this has not been fully explored in infants. Infancy is an important developmental period that may influence a person's long-term health. Infant development can be affected by diet, which also interacts with the developing gut microbiota.
OBJECTIVES
This study aimed to explore the associations between diet, the gut microbiota, and the serum metabolome of 1-y-old infants with the overarching goal of identifying serum biomarkers of diet and/or the gut microbiota.
METHODS
We derived dietary patterns of 1-y-old infants (n = 182) participating in the Canadian South Asian Birth Cohort (START) study. We compared gut microbiota α-diversity and β-diversity and taxa relative abundance from 16S rRNA gene profiles with dietary patterns (PERMANOVA, Envfit) and investigated diet-serum metabolite associations using a multivariate analysis (partial least squares-discriminant analysis) and univariate analysis (t test). We explored the effect of nondietary factors on diet-serum metabolite relationships by incorporating diet, the gut microbiota, and maternal, perinatal, and infant characteristics in a multivariable forward stepwise regression. We replicated this analysis in White European infants, from the CHILD Cohort Study (n = 81).
RESULTS
A dietary pattern characterized by formula consumption and negatively associated with breastfeeding most strongly predicted variation in the gut microbiota (R
CONCLUSIONS
Formula consumption and breastfeeding most strongly predicted the serum metabolites of 1-y-old infants, even when the gut microbiota, solid food consumption, and other covariates were considered.

Identifiants

DOI: 10.1016/j.tjnut.2022.12.016 PMID: 36894240
pubmed: 36894240
pii: S0022-3166(22)13261-X
doi: 10.1016/j.tjnut.2022.12.016
pii:
doi:

Substances chimiques

RNA, Ribosomal, 16S 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

470-482

Subventions

Organisme : CIHR
ID : RFA# 201301FH6
Pays : Canada
Organisme : CIHR
ID : INC-109205
Pays : Canada

Informations de copyright

Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Colin Y Bruce (CY)

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.

Meera Shanmuganathan (M)

Department of Chemistry and Chemical Biology, McMaster University, Hamilton, Ontario, Canada.

Sandi M Azab (SM)

Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

Elinor Simons (E)

Departments of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada.

Piushkumar Mandhane (P)

Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.

Stuart E Turvey (SE)

BC Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada; Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

Padmaja Subbarao (P)

Hospital for Sick Children and Department of Pediatrics & Physiology, University of Toronto, Toronto, Ontario, Canada.

Meghan B Azad (MB)

Departments of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada; Manitoba Interdisciplinary Lactation Centre (MILC), Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada; Department of Food and Human Nutritional Science, University of Manitoba, Winnipeg, Manitoba, Canada.

Philip Britz-McKibbin (P)

Department of Chemistry and Chemical Biology, McMaster University, Hamilton, Ontario, Canada.

Sonia S Anand (SS)

Department of Medicine, McMaster University, Hamilton, Ontario, Canada; Department of Health Research Methods, Evidence & Impact, McMaster University, Hamilton, Ontario, Canada.

Russell J de Souza (RJ)

Department of Health Research Methods, Evidence & Impact, McMaster University, Hamilton, Ontario, Canada.

Jennifer C Stearns (JC)

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada; Department of Medicine, McMaster University, Hamilton, Ontario, Canada; Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada. Electronic address: stearns@mcmaster.ca.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › The Relationship Between Diet, Gut Microbiota,...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › The Relationship Between Diet, Gut Microbiota,...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The Relationship Between Diet, Gut Microbiota,...
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questionsmedicales.fr › Environnement et santé publique › Environnement › Écosystème › Biodiversité › Biote › Microbiote › Microbiome gastro-intestinal › The Relationship Between Diet, Gut Microbiota,...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › The Relationship Between Diet, Gut Microbiota,...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN ribosomique › ARN ribosomique 16S › The Relationship Between Diet, Gut Microbiota,...
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