Inhibition of NHE1 transport activity and gene transcription in DRG neurons in oxaliplatin-induced painful peripheral neurotoxicity.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
09 03 2023
09 03 2023
Historique:
received:
07
12
2022
accepted:
06
03
2023
entrez:
9
3
2023
pubmed:
10
3
2023
medline:
14
3
2023
Statut:
epublish
Résumé
Oxaliplatin (OHP)-induced peripheral neurotoxicity (OIPN), one of the major dose-limiting side effects of colorectal cancer treatment, is characterized by both acute and chronic syndromes. Acute exposure to low dose OHP on dorsal root ganglion (DRG) neurons is able to induce an increase in intracellular calcium and proton concentration, thus influencing ion channels activity and neuronal excitability. The Na
Identifiants
pubmed: 36894669
doi: 10.1038/s41598-023-31095-9
pii: 10.1038/s41598-023-31095-9
pmc: PMC9998445
doi:
Substances chimiques
Oxaliplatin
04ZR38536J
Sodium-Hydrogen Exchangers
0
SLC9A1 protein, human
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3991Informations de copyright
© 2023. The Author(s).
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