Evidence against altered excitatory/inhibitory balance in the posteromedial cortex of young adult APOE E4 carriers: A resting state
1H-MRS
APOE E4
Alzheimer's disease
Default network
GABA
Glutamate
Journal
Neuroimage. Reports
ISSN: 2666-9560
Titre abrégé: Neuroimage Rep
Pays: Netherlands
ID NLM: 9918227365206676
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
06
05
2021
revised:
09
09
2021
accepted:
04
10
2021
entrez:
10
3
2023
pubmed:
1
12
2021
medline:
1
12
2021
Statut:
ppublish
Résumé
A strategy to gain insight into early changes that may predispose people to Alzheimer's disease (AD) is to study the brains of younger cognitively healthy people that are at increased genetic risk of AD. The Apolipoprotein (APOE) E4 allele is the strongest genetic risk factor for AD, and several neuroimaging studies comparing APOE E4 carriers with non-carriers at age ∼20-30 years have detected hyperactivity (or reduced deactivation) in posteromedial cortex (PMC), a key hub of the default network (DN), which has a high susceptibility to early amyloid deposition in AD. Transgenic mouse models suggest such early network activity alterations may result from altered excitatory/inhibitory (E/I) balance, but this is yet to be examined in humans. Here we test the hypothesis that PMC fMRI hyperactivity could be underpinned by altered levels of excitatory (glutamate) and/or inhibitory (GABA) neurotransmitters in this brain region. Forty-seven participants (20 APOE E4 carriers and 27 non-carriers) aged 18-25 years underwent resting-state proton magnetic resonance spectroscopy (
Identifiants
pubmed: 36896169
doi: 10.1016/j.ynirp.2021.100059
pii: S2666-9560(21)00057-X
pmc: PMC9986794
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100059Informations de copyright
Crown Copyright © 2021 Published by Elsevier Inc.
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Références
Lancet Neurol. 2013 Feb;12(2):207-16
pubmed: 23332364
Mol Neurodegener. 2019 Jun 11;14(1):24
pubmed: 31186040
Trends Cogn Sci. 2011 Nov;15(11):520-6
pubmed: 21983147
Neurochem Res. 2014 Jan;39(1):1-36
pubmed: 24258018
Sci Rep. 2015 Nov 10;5:16322
pubmed: 26552581
Behav Res Methods. 2009 Nov;41(4):1149-60
pubmed: 19897823
Nat Med. 2018 Dec;24(12):1910-1918
pubmed: 30374196
Bioessays. 2015 Jun;37(6):624-32
pubmed: 25773221
Alzheimers Dement. 2018 Apr;14(4):535-562
pubmed: 29653606
Lancet Neurol. 2012 Dec;11(12):1048-56
pubmed: 23137948
Neuroimage. 2015 Sep;118:292-300
pubmed: 26072254
Perspect Psychol Sci. 2014 May;9(3):319-32
pubmed: 26173267
Nature. 2020 May;581(7806):71-76
pubmed: 32376954
Brain. 2018 Jun 1;141(6):1828-1839
pubmed: 29672664
Neuroimage. 2014 Jun;93 Pt 1:124-37
pubmed: 24560717
Acta Neuropathol. 1991;82(4):239-59
pubmed: 1759558
Nat Rev Neurosci. 2013 May;14(5):365-76
pubmed: 23571845
JAMA. 1997 Oct 22-29;278(16):1349-56
pubmed: 9343467
Lancet Neurol. 2018 May;17(5):434-444
pubmed: 29555425
Brain Neurosci Adv. 2017 Aug 4;1(1):
pubmed: 28944298
Neurotherapeutics. 2017 Jul;14(3):662-676
pubmed: 28560709
EMBO Mol Med. 2016 Jun 01;8(6):595-608
pubmed: 27025652
Alzheimers Dement. 2014 Sep;10(5):552-61
pubmed: 24239247
Philos Trans R Soc Lond B Biol Sci. 2021 Jan 4;376(1815):20190634
pubmed: 33190605
J Neurosci. 2005 Aug 24;25(34):7709-17
pubmed: 16120771
Brain. 2019 Aug 1;142(8):2492-2509
pubmed: 31199481
Neuroimage. 2012 Aug 15;62(2):1121-30
pubmed: 22248578
J Neurosci. 2010 Oct 13;30(41):13707-17
pubmed: 20943911
Acta Neuropathol. 2011 Feb;121(2):171-81
pubmed: 21170538
Cell Stem Cell. 2009 Dec 4;5(6):634-45
pubmed: 19951691
Proc Natl Acad Sci U S A. 2021 Jul 6;118(27):
pubmed: 34193521
Nat Commun. 2021 May 10;12(1):2603
pubmed: 33972518
Magn Reson Imaging. 2015 Oct;33(8):1013-8
pubmed: 26117693
Arch Gen Psychiatry. 2002 Sep;59(9):851-8
pubmed: 12215085
Neuropsychologia. 2008;46(6):1679-87
pubmed: 18346764
Nat Commun. 2017 Oct 31;8(1):1214
pubmed: 29089479
IEEE Trans Med Imaging. 2001 Jan;20(1):45-57
pubmed: 11293691
J Magn Reson Imaging. 2014 Dec;40(6):1445-52
pubmed: 25548816
Neurobiol Aging. 1995 May-Jun;16(3):271-8; discussion 278-84
pubmed: 7566337
Cell Rep. 2015 May 12;11(6):859-865
pubmed: 25937280
Neurobiol Aging. 2017 Jun;54:103-111
pubmed: 28363111
Alzheimers Dement. 2020 Sep;16(9):1312-1329
pubmed: 32543726
J Neurochem. 2013 Jan;124(1):4-14
pubmed: 22862561
Philos Trans R Soc Lond B Biol Sci. 2016 Aug 5;371(1700):
pubmed: 27377723
Science. 2015 Oct 23;350(6259):430-3
pubmed: 26494756
Science. 1993 Aug 13;261(5123):921-3
pubmed: 8346443
Neurobiol Learn Mem. 2016 Oct;134 Pt A:123-134
pubmed: 26805590
Elife. 2019 Apr 30;8:
pubmed: 31038453
Psychon Bull Rev. 2018 Feb;25(1):207-218
pubmed: 28353065
Sci Rep. 2019 Jan 24;9(1):467
pubmed: 30679549
Hum Brain Mapp. 2012 Feb;33(2):455-65
pubmed: 21416560
Front Psychol. 2014 Jul 29;5:781
pubmed: 25120503
J Neurosci. 2013 Nov 20;33(47):18566-73
pubmed: 24259578
Neurobiol Aging. 2019 Jan;73:211-218
pubmed: 30390554
Neuroimage. 2020 Oct 15;220:117112
pubmed: 32619710
Nat Rev Neurosci. 2012 Oct;13(10):713-26
pubmed: 22992647
Acta Neuropathol. 2020 Dec;140(6):793-810
pubmed: 32865691
Nat Neurosci. 2020 Oct;23(10):1183-1193
pubmed: 32778792
Proc Natl Acad Sci U S A. 1993 Jun 15;90(12):5662-6
pubmed: 8516315
Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1563-8
pubmed: 16432221
Hum Brain Mapp. 2015 Aug;36(8):3204-12
pubmed: 26059006
Nat Rev Neurosci. 2018 Nov;19(11):687-700
pubmed: 30266970
Neuroimage. 2013 Jan 1;64:112-9
pubmed: 23000786
J Alzheimers Dis Rep. 2019 May 15;3(1):103-112
pubmed: 31259307
NMR Biomed. 2021 May;34(5):e4484
pubmed: 33559967
Neurology. 2016 May 10;86(19):1754-61
pubmed: 27164711
Cortex. 2016 Aug;81:104-17
pubmed: 27182810
Elife. 2017 Feb 08;6:
pubmed: 28177283
Biochem J. 1994 Feb 15;298 ( Pt 1):121-7
pubmed: 7907470
Neuron. 2019 Mar 6;101(5):820-838
pubmed: 30844401
Neurobiol Aging. 2015 Jan;36(1):53-9
pubmed: 25169676
Brain. 2006 Nov;129(Pt 11):2908-22
pubmed: 17012294
Magn Reson Med. 2017 Apr;77(4):1377-1389
pubmed: 28150876
Neurobiol Aging. 2020 Nov;95:46-55
pubmed: 32750666
Nat Commun. 2017 Nov 13;8(1):1464
pubmed: 29133888
Cold Spring Harb Perspect Biol. 2017 Aug 1;9(8):
pubmed: 28289062
Neurobiol Aging. 2019 Jan;73:82-91
pubmed: 30339963
Nat Neurosci. 2011 Jun;14(6):750-6
pubmed: 21532579
J Int Neuropsychol Soc. 2002 Nov;8(7):934-42
pubmed: 12405545
Neuron. 2014 Nov 5;84(3):608-22
pubmed: 25442939
Neurosci Biobehav Rev. 2021 Oct;129:142-153
pubmed: 34310975
Nat Rev Neurosci. 2016 Dec;17(12):777-792
pubmed: 27829687
Med Image Comput Comput Assist Interv. 2006;9(Pt 2):58-66
pubmed: 17354756
Annu Rev Neurosci. 2015 Jul 8;38:433-47
pubmed: 25938726
J Magn Reson Imaging. 2015 May;41(5):1326-31
pubmed: 24863149
Magn Reson Med. 2016 Oct;76(4):1083-91
pubmed: 26502373
Neuroimage. 2019 Jan 15;185:388-397
pubmed: 30359729
Hum Brain Mapp. 2019 Jul;40(10):2884-2898
pubmed: 30865358
Trends Cogn Sci. 2020 Jun;24(6):451-465
pubmed: 32340798
Annu Rev Neurosci. 2018 Jul 8;41:277-297
pubmed: 29986165
Arch Neurol. 2010 Jan;67(1):93-8
pubmed: 20065135
J Neurosci Methods. 2014 Jan 15;221:183-8
pubmed: 24459715
Neuroimage. 2021 Oct 15;240:118304
pubmed: 34329959
Mol Psychiatry. 2020 Dec;25(12):3380-3398
pubmed: 31431685
Scand J Psychol. 2018 Feb;59(1):91-103
pubmed: 29356002
Nat Rev Dis Primers. 2015 Oct 15;1:15056
pubmed: 27188934
Hum Brain Mapp. 2018 Jun;39(6):2381-2390
pubmed: 29488277
Neurology. 2000 Jul 25;55(2):210-7
pubmed: 10908893
Neuroimage. 2017 May 15;152:509-516
pubmed: 28323160
Brain Res. 2015 Feb 9;1597:129-38
pubmed: 25481417
Mol Neurobiol. 2021 Jun;58(6):2757-2769
pubmed: 33496907
Neurobiol Aging. 2016 Dec;48:195-203
pubmed: 27718422
Magn Reson Med. 2019 Aug;82(2):527-550
pubmed: 30919510
Biol Psychiatry. 2008 Jun 15;63(12):1178-84
pubmed: 18061146
Int J Mol Sci. 2020 Dec 07;21(23):
pubmed: 33297460
Neuroimage. 2018 Feb 1;166:285-292
pubmed: 29108941
Neuron. 2020 Aug 5;107(3):417-435
pubmed: 32579881
Neuroimage. 2014 Feb 1;86:43-52
pubmed: 23246994
NMR Biomed. 2015 Jun;28(6):685-93
pubmed: 25904240
Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):7209-14
pubmed: 19357304
J Neurosci. 2017 Jul 19;37(29):6894-6901
pubmed: 28652414
NMR Biomed. 1998 Oct;11(6):266-72
pubmed: 9802468
Semin Cell Dev Biol. 2021 Aug;116:146-159
pubmed: 33573856
Alzheimers Dement. 2015 Jun;11(6):648-57.e1
pubmed: 25160043
J Magn Reson Imaging. 2015 Nov;42(5):1431-40
pubmed: 26172043
J Alzheimers Dis. 2015;45(3):757-70
pubmed: 25633678
Neuron. 2010 Nov 4;68(3):428-41
pubmed: 21040845
NMR Biomed. 2021 May;34(5):e4257
pubmed: 32084297
Ageing Res Rev. 2020 Sep;62:101133
pubmed: 32717407
Nat Rev Neurosci. 2005 Mar;6(3):215-29
pubmed: 15738957
NMR Biomed. 2001 Jun;14(4):278-83
pubmed: 11410946
Proc Natl Acad Sci U S A. 2009 May 19;106(20):8356-61
pubmed: 19416820
Nat Neurosci. 2020 Jul;23(7):788-799
pubmed: 32601411
J Magn Reson Imaging. 2009 Nov;30(5):1155-62
pubmed: 19856449
PLoS One. 2015 Mar 26;10(3):e0120101
pubmed: 25811453
Magn Reson Med. 2011 Jan;65(1):1-12
pubmed: 20878762
Neuroimage. 2021 Feb 1;226:117536
pubmed: 33186716
Acta Neuropathol. 2016 May;131(5):709-23
pubmed: 26884068
Neuroimage Clin. 2019;22:101776
pubmed: 30927605