Nerve regeneration by interferon intervention in aging brain.
Journal
EMBO molecular medicine
ISSN: 1757-4684
Titre abrégé: EMBO Mol Med
Pays: England
ID NLM: 101487380
Informations de publication
Date de publication:
11 04 2023
11 04 2023
Historique:
received:
27
01
2023
accepted:
06
02
2023
medline:
12
4
2023
pubmed:
11
3
2023
entrez:
10
3
2023
Statut:
ppublish
Résumé
Neural stem cells (NSCs) are shielded from viral infection by interferon (IFN) defense. As individuals age, activation of NSC decreases with a significant decline of stemness marker Sex-determining region Y box 2 (Sox2) while IFN signaling enhances (Kalamakis et al, 2019). Given that low-level type-I IFN under normal physiological conditions can promote dormant hematopoietic stem cell differentiation (Baldridge et al, 2010), whether there is an inner connection between IFN signaling and NSC function remains elusive. In this issue of EMBO Molecular Medicine, Carvajal Ibanez et al (2023) reveal that IFN-β, a type-I interferon, induces cell-type-specific interferon-stimulated genes (ISGs) and regulates global protein synthesis by orchestrating mTOR1 activity and stem cell cycle that retain NSCs at the G
Identifiants
pubmed: 36896594
doi: 10.15252/emmm.202217307
pmc: PMC10086575
doi:
Substances chimiques
Interferons
9008-11-1
Types de publication
Journal Article
Comment
Langues
eng
Sous-ensembles de citation
IM
Pagination
e17307Commentaires et corrections
Type : CommentOn
Informations de copyright
© 2023 The Authors. Published under the terms of the CC BY 4.0 license.
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