7α,25-Dihydroxycholesterol-Induced Oxiapoptophagic Chondrocyte Death via the Modulation of p53-Akt-mTOR Axis in Osteoarthritis Pathogenesis.
25-dihydroxycholesterol
7α
chondrocytes
osteoarthritis
oxiapoptophagy
oxysterol
Journal
Molecules and cells
ISSN: 0219-1032
Titre abrégé: Mol Cells
Pays: Korea (South)
ID NLM: 9610936
Informations de publication
Date de publication:
30 04 2023
30 04 2023
Historique:
received:
23
09
2022
revised:
29
11
2022
accepted:
05
12
2022
medline:
7
4
2023
pubmed:
11
3
2023
entrez:
10
3
2023
Statut:
ppublish
Résumé
This study aimed to exploring the pathophysiological mechanism of 7α,25-dihydroxycholesterol (7α,25-DHC) in osteoarthritis (OA) pathogenesis. 7α,25-DHC accelerated the proteoglycan loss in
Identifiants
pubmed: 36896597
pii: molcells.2023.2149
doi: 10.14348/molcells.2023.2149
pmc: PMC10086556
doi:
Substances chimiques
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
Tumor Suppressor Protein p53
0
Beclin-1
0
TOR Serine-Threonine Kinases
EC 2.7.11.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
245-255Références
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