Differential Brain Structural and Functional Patterns in Crohn's Disease Patients are Associated with Different Disease Stages.
Crohn’s disease
functional magnetic resonance imaging
resting-state fMRI
voxel-based morphometry
Journal
Inflammatory bowel diseases
ISSN: 1536-4844
Titre abrégé: Inflamm Bowel Dis
Pays: England
ID NLM: 9508162
Informations de publication
Date de publication:
01 08 2023
01 08 2023
Historique:
received:
25
08
2022
medline:
3
8
2023
pubmed:
11
3
2023
entrez:
10
3
2023
Statut:
ppublish
Résumé
Crohn's disease (CD) is an inflammatory, chronic disorder that alternates between a quiescent phase and inflammatory flare-ups. Research has begun to elucidate the impact of CD in modulating brain structure and function. The previous neuroimaging studies mainly involved CD patients in remission (CD-R); therefore, little is known about how inflammation influences brain-related features in different stages of the disease. We carried out a magnetic resonance imaging (MRI) study to explore whether the different levels of disease activity may differentially affect brain structure and function. Fourteen CD-R patients, 19 patients with mild to moderate inflammatory activity (CD-A), and 18 healthy controls (HCs) underwent an MRI scan including structural and functional sequences. Between-group comparisons showed morphological and functional brain differences distinctively associated with the stage of disease activity. The CD-A patients had reduced gray matter within the posterior cingulate cortex (PCC) relative to CD-R patients. Analysis on resting fMRI data showed the following patterns: (1) increased connectivity within the left fronto-parietal network (in the superior parietal lobe) in CD-R patients relative to CD-A patients; (2) decreased connectivity in the motor network (in parietal and motor areas) in the CD-A group relative to the HC group; (3) reduced connectivity in the motor network and (4) in the language network (in parietal areas and in the PCC) in CD-R patients relative to HC. The present findings represent a further step towards understanding brain morphological and functional changes in the active vs remission stages of CD patients. We found morphological and functional brain changes associated with different stages of disease activity in Crohn’s disease. These findings may represent the neural correlates of fatigue, irritable bowel syndrome–like symptoms, and cognitive-emotional impairments; these could be useful for evaluating disease progression.
Sections du résumé
BACKGROUND
Crohn's disease (CD) is an inflammatory, chronic disorder that alternates between a quiescent phase and inflammatory flare-ups. Research has begun to elucidate the impact of CD in modulating brain structure and function. The previous neuroimaging studies mainly involved CD patients in remission (CD-R); therefore, little is known about how inflammation influences brain-related features in different stages of the disease. We carried out a magnetic resonance imaging (MRI) study to explore whether the different levels of disease activity may differentially affect brain structure and function.
METHODS
Fourteen CD-R patients, 19 patients with mild to moderate inflammatory activity (CD-A), and 18 healthy controls (HCs) underwent an MRI scan including structural and functional sequences.
RESULTS
Between-group comparisons showed morphological and functional brain differences distinctively associated with the stage of disease activity. The CD-A patients had reduced gray matter within the posterior cingulate cortex (PCC) relative to CD-R patients. Analysis on resting fMRI data showed the following patterns: (1) increased connectivity within the left fronto-parietal network (in the superior parietal lobe) in CD-R patients relative to CD-A patients; (2) decreased connectivity in the motor network (in parietal and motor areas) in the CD-A group relative to the HC group; (3) reduced connectivity in the motor network and (4) in the language network (in parietal areas and in the PCC) in CD-R patients relative to HC.
CONCLUSIONS
The present findings represent a further step towards understanding brain morphological and functional changes in the active vs remission stages of CD patients.
We found morphological and functional brain changes associated with different stages of disease activity in Crohn’s disease. These findings may represent the neural correlates of fatigue, irritable bowel syndrome–like symptoms, and cognitive-emotional impairments; these could be useful for evaluating disease progression.
Autres résumés
Type: plain-language-summary
(eng)
We found morphological and functional brain changes associated with different stages of disease activity in Crohn’s disease. These findings may represent the neural correlates of fatigue, irritable bowel syndrome–like symptoms, and cognitive-emotional impairments; these could be useful for evaluating disease progression.
Identifiants
pubmed: 36897213
pii: 7075665
doi: 10.1093/ibd/izad029
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1297-1305Informations de copyright
© The Author(s) 2023. Published by Oxford University Press on behalf of Crohn’s & Colitis Foundation. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.