Source of nicotinamide governs its metabolic fate in cultured cells, mice, and humans.

Humans Mice Animals NAD / metabolism Niacinamide / pharmacology Nicotinamide Phosphoribosyltransferase / metabolism Cells, Cultured Aging Cytokines / metabolism
1-methylnicotinamide CP: Metabolism NAD NAMPT NAMPT activator metabolite tracing nicotinamide salvage pathway

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
28 03 2023
Historique:
received: 13 09 2022
revised: 17 01 2023
accepted: 17 02 2023
medline: 3 4 2023
pubmed: 11 3 2023
entrez: 10 3 2023
Statut: ppublish

Résumé

Metabolic routing of nicotinamide (NAM) to NAD

Identifiants

DOI: 10.1016/j.celrep.2023.112218 PMID: 36897780
pubmed: 36897780
pii: S2211-1247(23)00229-2
doi: 10.1016/j.celrep.2023.112218
pii:
doi:

Substances chimiques

NAD 0U46U6E8UK
Niacinamide 25X51I8RD4
Nicotinamide Phosphoribosyltransferase EC 2.4.2.12
Cytokines 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

112218

Informations de copyright

Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Tumpa Dutta (T)

Translational Research Institute, AdventHealth Orlando, Orlando, FL 32804, USA. Electronic address: tumpa.dutta@adventhealth.com.

Nidhi Kapoor (N)

Translational Research Institute, AdventHealth Orlando, Orlando, FL 32804, USA.

Meril Mathew (M)

Translational Research Institute, AdventHealth Orlando, Orlando, FL 32804, USA.

Suban S Chakraborty (SS)

Translational Research Institute, AdventHealth Orlando, Orlando, FL 32804, USA.

Nathan P Ward (NP)

Department of Cancer Physiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.

Nicolas Prieto-Farigua (N)

Department of Cancer Physiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.

Aimee Falzone (A)

Department of Cancer Physiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.

James P DeLany (JP)

Translational Research Institute, AdventHealth Orlando, Orlando, FL 32804, USA.

Steven R Smith (SR)

Translational Research Institute, AdventHealth Orlando, Orlando, FL 32804, USA.

Paul M Coen (PM)

Translational Research Institute, AdventHealth Orlando, Orlando, FL 32804, USA.

Gina M DeNicola (GM)

Department of Cancer Physiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.

Stephen J Gardell (SJ)

Translational Research Institute, AdventHealth Orlando, Orlando, FL 32804, USA. Electronic address: stephen.gardell@adventhealth.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Source of nicotinamide governs its metabolic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Source of nicotinamide governs its metabolic...
questionsmedicales.fr › Eucaryotes › Animaux › Source of nicotinamide governs its metabolic...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › NAD › Source of nicotinamide governs its metabolic...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyridines › Acides nicotiniques › Nicotinamide › Source of nicotinamide governs its metabolic...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Glycosyltransferase › Pentosyltransferases › Nicotinamide phosphoribosyltransferase › Source of nicotinamide governs its metabolic...
questionsmedicales.fr › Cellules › Cellules cultivées › Source of nicotinamide governs its metabolic...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Source of nicotinamide governs its metabolic...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Source of nicotinamide governs its metabolic...