Unapparent systemic effects of regional anticoagulation with citrate in continuous renal replacement therapy: a narrative review.
Calcium balance
Citrate anticoagulation
Hormones
Magnesium
Phosphate
Review
Journal
Annals of intensive care
ISSN: 2110-5820
Titre abrégé: Ann Intensive Care
Pays: Germany
ID NLM: 101562873
Informations de publication
Date de publication:
11 Mar 2023
11 Mar 2023
Historique:
received:
16
11
2022
accepted:
20
02
2023
entrez:
10
3
2023
pubmed:
11
3
2023
medline:
11
3
2023
Statut:
epublish
Résumé
The use of citrate, through reversible binding of calcium, has become the preferred choice for anticoagulation in continuous renal replacement therapy in the critically ill patient. Though generally considered as very efficacious in acute kidney injury, this type of anticoagulation can cause acid-base disorders as well as citrate accumulation and overload, phenomena which have been well described. The purpose of this narrative review is to provide an overview of some other, non-anticoagulation effects of citrate chelation during its use as anticoagulant. We highlight the effects seen on the calcium balance and hormonal status, phosphate and magnesium balance, as well as oxidative stress resulting from these unapparent effects. As most of these data on these non-anticoagulation effects have been obtained in small observational studies, new and larger studies documenting both short- and long-term effects should be undertaken. Subsequent future guidelines for citrate-based continuous renal replacement therapy should take not only the metabolic but also these unapparent effects into account.
Identifiants
pubmed: 36899104
doi: 10.1186/s13613-023-01113-0
pii: 10.1186/s13613-023-01113-0
pmc: PMC10006386
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
16Informations de copyright
© 2023. The Author(s).
Références
Crit Care. 2015 Sep 08;19:321
pubmed: 26353802
Crit Care Med. 2015 Aug;43(8):1622-9
pubmed: 25853591
N Engl J Med. 2008 Jul 3;359(1):7-20
pubmed: 18492867
Crit Care Resusc. 2012 Dec;14(4):274-82
pubmed: 23230876
BMC Nephrol. 2013 Oct 25;14:232
pubmed: 24156306
Ann Intensive Care. 2021 Jan 22;11(1):13
pubmed: 33481169
J Clin Invest. 1973 Aug;52(8):1958-71
pubmed: 4719672
Crit Care. 2017 Nov 19;21(1):281
pubmed: 29151020
BMC Nephrol. 2021 Dec 11;22(1):409
pubmed: 34895160
J Am Soc Nephrol. 1999 May;10(5):980-5
pubmed: 10232683
BMC Nephrol. 2014 Oct 04;15:163
pubmed: 25281195
Blood Purif. 2012;33(1-3):80-7
pubmed: 22212643
Ther Apher Dial. 2011 Dec;15(6):556-64
pubmed: 22107692
Crit Care. 2016 May 13;20(1):144
pubmed: 27176622
J Clin Endocrinol Metab. 1989 Sep;69(3):593-9
pubmed: 2760172
Blood Purif. 2016;41(1-3):41-7
pubmed: 26960213
Am J Kidney Dis. 2004 Dec;44(6):1110-4
pubmed: 15558534
Kidney Int. 1974 Jun;5(6):437-45
pubmed: 4421787
Acta Anaesthesiol Scand. 2011 Jan;55(1):39-45
pubmed: 21039362
Blood Purif. 2007;25(3):267-73
pubmed: 17446700
Clin Kidney J. 2016 Apr;9(2):205-10
pubmed: 26985370
J Clin Endocrinol Metab. 1981 Oct;53(4):823-7
pubmed: 6895227
PLoS One. 2016 Jul 08;11(7):e0158179
pubmed: 27391902
Blood Purif. 2012;34(3-4):306-12
pubmed: 23235269
Nephron Clin Pract. 2013;124(1-2):124-31
pubmed: 24192818
J Am Soc Nephrol. 2017 Jun;28(6):1877-1885
pubmed: 28028134
Crit Care. 2010;14(4):R147
pubmed: 20682049
J Crit Care. 2020 Oct;59:16-22
pubmed: 32485438
Clin J Am Soc Nephrol. 2018 Apr 6;13(4):531-541
pubmed: 29519954
Hemodial Int. 2019 Jan;23(1):33-41
pubmed: 30716204
Nephron Clin Pract. 2012;120(4):c179-84
pubmed: 22890468
Clin J Am Soc Nephrol. 2022 May;17(5):634-642
pubmed: 35477673
Intensive Care Med. 2004 Aug;30(8):1662-5
pubmed: 15156308
N Engl J Med. 2009 Oct 22;361(17):1627-38
pubmed: 19846848
Am J Kidney Dis. 2013 Jun;61(6):1043-5
pubmed: 23434061
Cytokine. 2012 Dec;60(3):601-7
pubmed: 23006672
Am J Med. 1983 Dec;75(6):973-6
pubmed: 6689108
Nephrol Dial Transplant. 2014 Feb;29(2):282-9
pubmed: 24103811
J Steroid Biochem Mol Biol. 2010 Jul;121(1-2):376-82
pubmed: 20362668
Hemodial Int. 2013 Apr;17(2):313-20
pubmed: 22882732
J Crit Care. 2013 Oct;28(5):884.e7-14
pubmed: 23683569
BMC Nephrol. 2014 Jan 17;15:19
pubmed: 24438360
Clin Chim Acta. 2020 Jul;506:84-91
pubmed: 32178977
Nephrol Dial Transplant. 2013 Apr;28(4):910-6
pubmed: 22764195
Blood Purif. 2017;44(1):8-15
pubmed: 28219057
J Clin Invest. 1984 Dec;74(6):2136-43
pubmed: 6549016
Endocrinology. 2002 Feb;143(2):587-95
pubmed: 11796514
Semin Nephrol. 2019 Jan;39(1):41-56
pubmed: 30606407
Kidney Int. 2009 Feb;75(3):312-6
pubmed: 19002217
Clin J Am Soc Nephrol. 2018 Apr 6;13(4):524-526
pubmed: 29507007
Clin Endocrinol (Oxf). 2013 Oct;79(4):491-8
pubmed: 23414198
Nephron. 2001 Oct;89(2):233-6
pubmed: 11549910
Kidney Blood Press Res. 2013;37(4-5):240-51
pubmed: 23868100
Blood Purif. 2016;42(1):18-26
pubmed: 26949936
Crit Care Resusc. 2011 Jun;13(2):72-81
pubmed: 21627574
Ann Intensive Care. 2022 Mar 31;12(1):29
pubmed: 35355147
PLoS One. 2020 Sep 11;15(9):e0238867
pubmed: 32915900
Int J Artif Organs. 2021 Nov;44(11):807-815
pubmed: 34472996
Crit Care. 2012 Dec 07;16(6):249
pubmed: 23216871
Crit Care. 2015 Dec 09;19:427
pubmed: 26645989
Am J Phys Med Rehabil. 2022 Jan 1;101(1):61-63
pubmed: 34657087
Semin Cell Dev Biol. 2016 Jan;49:37-43
pubmed: 26612442
Int J Artif Organs. 2013 Dec;36(12):845-52
pubmed: 24362894
Nephrol Dial Transplant. 2011 Nov;26(11):3508-14
pubmed: 21382993
Crit Care. 2013 Sep 19;17(5):R205
pubmed: 24050634