Genomics-Driven Precision Medicine in Pediatric Solid Tumors.
actionable mutations
pediatric solid tumor
precision medicine
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
23 Feb 2023
23 Feb 2023
Historique:
received:
18
01
2023
revised:
10
02
2023
accepted:
15
02
2023
entrez:
11
3
2023
pubmed:
12
3
2023
medline:
12
3
2023
Statut:
epublish
Résumé
Over the past decades, several study programs have conducted genetic testing in cancer patients to identify potential genetic targets for the development of precision therapeutic strategies. These biomarker-driven trials have demonstrated improved clinical outcomes and progression-free survival rates in various types of cancers, especially for adult malignancies. However, similar progress in pediatric cancers has been slow due to their distinguished mutation profiles compared to adults and the low frequency of recurrent genomic alterations. Recently, increased efforts to develop precision medicine for childhood malignancies have led to the identification of genomic alterations and transcriptomic profiles of pediatric patients which presents promising opportunities to study rare and difficult-to-access neoplasms. This review summarizes the current state of known and potential genetic markers for pediatric solid tumors and provides perspectives on precise therapeutic strategies that warrant further investigations.
Identifiants
pubmed: 36900212
pii: cancers15051418
doi: 10.3390/cancers15051418
pmc: PMC10000495
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Genomic Thailand Project of the Health Systems Research Institute, Thailand
ID : HSRI64-130
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