Liquid Biopsies in Lung Cancer.
CTC
EV
ctDNA
liquid biopsy
lung cancer
miRNA
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
23 Feb 2023
23 Feb 2023
Historique:
received:
27
01
2023
revised:
20
02
2023
accepted:
20
02
2023
entrez:
11
3
2023
pubmed:
12
3
2023
medline:
12
3
2023
Statut:
epublish
Résumé
As lung cancer has the highest cancer-specific mortality rates worldwide, there is an urgent need for new therapeutic and diagnostic approaches to detect early-stage tumors and to monitor their response to the therapy. In addition to the well-established tissue biopsy analysis, liquid-biopsy-based assays may evolve as an important diagnostic tool. The analysis of circulating tumor DNA (ctDNA) is the most established method, followed by other methods such as the analysis of circulating tumor cells (CTCs), microRNAs (miRNAs), and extracellular vesicles (EVs). Both PCR- and NGS-based assays are used for the mutational assessment of lung cancer, including the most frequent driver mutations. However, ctDNA analysis might also play a role in monitoring the efficacy of immunotherapy and its recent accomplishments in the landscape of state-of-the-art lung cancer therapy. Despite the promising aspects of liquid-biopsy-based assays, there are some limitations regarding their sensitivity (risk of false-negative results) and specificity (interpretation of false-positive results). Hence, further studies are needed to evaluate the usefulness of liquid biopsies for lung cancer. Liquid-biopsy-based assays might be integrated into the diagnostic guidelines for lung cancer as a tool to complement conventional tissue sampling.
Identifiants
pubmed: 36900221
pii: cancers15051430
doi: 10.3390/cancers15051430
pmc: PMC10000706
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : German Ministry of Education and Research (BMBF)
ID : e:Med project MyPathSem (031 L0024)
Organisme : the Else Kröner-Fresenius-Stiftung
ID : project 2019_A162
Organisme : University of Münster
ID : project ME 12 19 14
Organisme : the Excellence Cluster
ID : Cells in Motion
Organisme : Volkswagen Foundation
ID : research project MTB-Report (ZN3424)
Organisme : Novartis Pharma GmbH
ID : InCa (Inflammation & Lung Cancer) Förderpreis 2021
Organisme : Medical Faculty
ID : the innovative medical research (IMF)
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