Impacts of Environmental Pollution on Brain Tumorigenesis.


Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
06 Mar 2023
Historique:
received: 22 12 2022
revised: 15 02 2023
accepted: 21 02 2023
entrez: 11 3 2023
pubmed: 12 3 2023
medline: 15 3 2023
Statut: epublish

Résumé

Pollutants consist of several components, known as direct or indirect mutagens, that can be associated with the risk of tumorigenesis. The increased incidence of brain tumors, observed more frequently in industrialized countries, has generated a deeper interest in examining different pollutants that could be found in food, air, or water supply. These compounds, due to their chemical nature, alter the activity of biological molecules naturally found in the body. The bioaccumulation leads to harmful effects for humans, increasing the risk of the onset of several pathologies, including cancer. Environmental components often combine with other risk factors, such as the individual genetic component, which increases the chance of developing cancer. The objective of this review is to discuss the impact of environmental carcinogens on modulating the risk of brain tumorigenesis, focusing our attention on certain categories of pollutants and their sources.

Identifiants

pubmed: 36902485
pii: ijms24055045
doi: 10.3390/ijms24055045
pmc: PMC10002587
pii:
doi:

Substances chimiques

Air Pollutants 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : POR FESR Regione Campania "Lotta al Covid" 2014-2020, FISR2020IP_01866 and AIRC18999, and Regione Campania (BURC: Legge 38/2020 art.16), Project:" Studi sulla lotta alle malattie ne-oplastiche
ID : FISR2020IP_01866, AIRC18999, Regione Campania (BURC: Legge 38/2020 art.16)

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Auteurs

Cristina Pagano (C)

Department of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", 80131 Naples, Italy.

Giovanna Navarra (G)

Department of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", 80131 Naples, Italy.

Laura Coppola (L)

Department of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", 80131 Naples, Italy.

Beatrice Savarese (B)

Department of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", 80131 Naples, Italy.

Giorgio Avilia (G)

Department of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", 80131 Naples, Italy.

Antonella Giarra (A)

Department of Chemical Sciences, University of Naples "Federico II", 80126 Naples, Italy.

Giovanni Pagano (G)

Department of Chemical Sciences, University of Naples "Federico II", 80126 Naples, Italy.

Alessandra Marano (A)

Department of Chemical Sciences, University of Naples "Federico II", 80126 Naples, Italy.

Marco Trifuoggi (M)

Department of Chemical Sciences, University of Naples "Federico II", 80126 Naples, Italy.

Maurizio Bifulco (M)

Department of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", 80131 Naples, Italy.

Chiara Laezza (C)

Institute of Endocrinology and Experimental Oncology (IEOS), National Research Council (CNR), 80131 Naples, Italy.

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Classifications MeSH