Hyperglycemia and Glycemic Variability Associated with Glucocorticoids in Women without Pre-Existing Diabetes Undergoing Neoadjuvant or Adjuvant Taxane Chemotherapy for Early-Stage Breast Cancer.
breast cancer
glucocorticoids
glycemic variability
steroid-induced hyperglycemia
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
28 Feb 2023
28 Feb 2023
Historique:
received:
09
02
2023
revised:
22
02
2023
accepted:
24
02
2023
entrez:
11
3
2023
pubmed:
12
3
2023
medline:
12
3
2023
Statut:
epublish
Résumé
Glucocorticoids, which are administered with chemotherapy, cause hyperglycemia. Glycemic variability among breast cancer patients without diabetes is not well known. A retrospective cohort study was conducted involving early-stage breast cancer patients without diabetes who received dexamethasone prior to neoadjuvant or adjuvant taxane chemotherapy between August 2017-December 2019. Random blood glucose levels were analyzed, and steroid-induced hyperglycemia (SIH) was defined as a random glucose level of >140 mg/dL. A multivariate proportional hazards model was used to identify the risk factors of SIH. Out of 100 patients, the median age was 53 years (IQR: 45-63.5). A total of 45% of patients were non-Hispanic White, 28% Hispanic, 19% Asian, and 5% African American. The incidence of SIH was 67%, and glycemic fluctuations were highest in those with glucose levels of >200 mg/dL. Non-Hispanic White patients represented a significant predictor for time to SIH, with a hazard ratio of 2.5 (95% CI: 1.04, 5.95,
Identifiants
pubmed: 36902693
pii: jcm12051906
doi: 10.3390/jcm12051906
pmc: PMC10004215
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NIA NIH HHS
ID : K76 AG074918
Pays : United States
Organisme : NIH HHS
ID : P30CA033572
Pays : United States
Références
Mol Neurobiol. 2016 Apr;53(3):1654-1660
pubmed: 25687433
Diabetes Metab Res Rev. 2018 Nov;34(8):e3047
pubmed: 30028067
J Breast Cancer. 2020 Aug 05;23(4):398-409
pubmed: 32908790
Curr Diab Rep. 2013 Feb;13(1):114-20
pubmed: 23090580
Jpn J Clin Oncol. 2015 Jul;45(7):637-41
pubmed: 25862826
Obes Res. 2001 Nov;9 Suppl 4:228S-233S
pubmed: 11707546
JAMA. 2008 Dec 17;300(23):2754-64
pubmed: 19088353
J Pediatr. 2009 Jul;155(1):73-8
pubmed: 19394046
Diabetes Res Clin Pract. 2018 May;139:203-220
pubmed: 29530386
Eur Heart J. 2013 Aug;34(31):2436-43
pubmed: 23641007
Endocrine. 2017 Apr;56(1):90-97
pubmed: 28058528
Front Endocrinol (Lausanne). 2020 Feb 18;11:60
pubmed: 32132977
Endocr Rev. 2010 Apr;31(2):171-82
pubmed: 19966012
Clin Cancer Res. 2011 Sep 15;17(18):6052-60
pubmed: 21750201
Diabetes Res Clin Pract. 2021 Apr;174:108751
pubmed: 33722701
Oncol Nurs Forum. 2014 Nov 1;41(6):E343-54
pubmed: 25355030
J Clin Med. 2021 May 16;10(10):
pubmed: 34065762
Lancet Diabetes Endocrinol. 2019 Mar;7(3):221-230
pubmed: 30115599
Nat Clin Pract Oncol. 2005 Jan;2(1):48-53
pubmed: 16264856
Curr Oncol. 2013 Dec;20(6):e532-8
pubmed: 24311953
Diab Vasc Dis Res. 2017 Jul;14(4):327-335
pubmed: 28301953
Diabetes Care. 2006 Dec;29(12):2728-9
pubmed: 17130214
Cancer Res Treat. 2016 Oct;48(4):1429-1437
pubmed: 26987397
Endocr Pract. 2009 Jul-Aug;15(5):469-74
pubmed: 19454391
Crit Care. 2010;14(4):R130
pubmed: 20615210
Diabetes Care. 2021 Jan;44(Suppl 1):S15-S33
pubmed: 33298413
Diabetes Care. 2014 Aug;37(8):2359-65
pubmed: 24812434
World J Crit Care Med. 2012 Feb 04;1(1):31-9
pubmed: 24701399
Diabetol Metab Syndr. 2010 Jul 21;2:49
pubmed: 20663179
Endocr Relat Cancer. 2010 May 18;17(2):539-51
pubmed: 20356977
Br J Cancer. 2015 Sep 1;113(5):827-32
pubmed: 26158425
Ann Nutr Metab. 2014;65(4):324-32
pubmed: 25402408
Clin Med (Lond). 2012 Apr;12(2):137-9
pubmed: 22586788
Clin Breast Cancer. 2004 Dec;5(5):371-6
pubmed: 15585076
Eur J Cancer. 2001 Sep;37(13):1590-8
pubmed: 11527683
Diabetes Care. 2018 Apr;41(4):755-761
pubmed: 29351960
Clin Breast Cancer. 2009 Feb;9(1):23-8
pubmed: 19299236
BMJ Open Diabetes Res Care. 2021 Mar;9(1):
pubmed: 33762313
Eur J Cancer Clin Oncol. 1989 Dec;25(12):1817-21
pubmed: 2698804
Am J Clin Oncol. 2011 Jun;34(3):292-6
pubmed: 20622641
Endocrinol Metab (Seoul). 2017 Jun;32(2):180-189
pubmed: 28555464
N Engl J Med. 2012 Feb 9;366(6):520-9
pubmed: 22149876
J Clin Oncol. 2009 May 1;27(13):2170-6
pubmed: 19307509
J Clin Endocrinol Metab. 2012 Jan;97(1):16-38
pubmed: 22223765