Osteoporosis and Celiac Disease: Updates and Hidden Pitfalls.
bone mineral density
bone–gut axis
celiac disease
management of osteoporosis
osteopenia
osteoporosis
sex-related differences
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
22 Feb 2023
22 Feb 2023
Historique:
received:
09
02
2023
revised:
15
02
2023
accepted:
20
02
2023
entrez:
11
3
2023
pubmed:
12
3
2023
medline:
15
3
2023
Statut:
epublish
Résumé
Celiac disease (CD) is an autoimmune disorder caused by gluten ingestion in genetically predisposed individuals. In addition to the typical gastrointestinal symptoms (e.g., diarrhea, bloating, and chronic abdominal pain), CD may also present with a broad spectrum of manifestations, including low bone mineral density (BMD) and osteoporosis. The etiopathology of bone lesions in CD is multifactorial and other conditions, rather than mineral and vitamin D malabsorption, may affect skeletal health, especially those related to the endocrine system. Here, we describe CD-induced osteoporosis in an attempt to enlighten new and less-known aspects, such as the influence of the intestinal microbiome and sex-related differences on bone health. This review describes the role of CD in the development of skeletal alterations to provide physicians with an updated overview on this debated topic and to improve the management of osteoporosis in CD.
Identifiants
pubmed: 36904090
pii: nu15051089
doi: 10.3390/nu15051089
pmc: PMC10005679
pii:
doi:
Substances chimiques
Glutens
8002-80-0
Vitamin D
1406-16-2
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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