Myricetin-induced suicidal erythrocyte death.
Calcium
Ceramide
Eryptosis
Myricetin
Oxidative stress
Phosphatidylserine exposure
Journal
Molecular biology reports
ISSN: 1573-4978
Titre abrégé: Mol Biol Rep
Pays: Netherlands
ID NLM: 0403234
Informations de publication
Date de publication:
May 2023
May 2023
Historique:
received:
05
12
2022
accepted:
21
02
2023
medline:
1
5
2023
pubmed:
12
3
2023
entrez:
11
3
2023
Statut:
ppublish
Résumé
Myricetin, a type of flavonol commonly found in fruits and herbs, has demonstrated anticancer properties by triggering the process of apoptosis or programmed cell death in tumor cells. Despite the absence of mitochondria and nuclei, erythrocytes can undergo programmed cell death, also known as eryptosis.This process is characterized by cell shrinkage, externalization of phosphatidylserine (PS) on the cell membrane, and the formation of membrane blebs. The signaling of eryptosis involves Ca Human erythrocytes were exposed to various concentrations of myricetin (2-8 µM) for 24 h. Flow cytometry was used to assess the markers of eryptosis, including PS exposure, cellular volume, cytosolic Ca Myricetin triggers eryptosis, which is accompanied and, at least in part, caused by Ca
Sections du résumé
BACKGROUND
BACKGROUND
Myricetin, a type of flavonol commonly found in fruits and herbs, has demonstrated anticancer properties by triggering the process of apoptosis or programmed cell death in tumor cells. Despite the absence of mitochondria and nuclei, erythrocytes can undergo programmed cell death, also known as eryptosis.This process is characterized by cell shrinkage, externalization of phosphatidylserine (PS) on the cell membrane, and the formation of membrane blebs. The signaling of eryptosis involves Ca
METHODS AND RESULTS
RESULTS
Human erythrocytes were exposed to various concentrations of myricetin (2-8 µM) for 24 h. Flow cytometry was used to assess the markers of eryptosis, including PS exposure, cellular volume, cytosolic Ca
CONCLUSION
CONCLUSIONS
Myricetin triggers eryptosis, which is accompanied and, at least in part, caused by Ca
Identifiants
pubmed: 36905403
doi: 10.1007/s11033-023-08350-3
pii: 10.1007/s11033-023-08350-3
doi:
Substances chimiques
Reactive Oxygen Species
0
myricetin
76XC01FTOJ
Ceramides
0
Annexins
0
Calcium
SY7Q814VUP
Phosphatidylserines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4253-4260Subventions
Organisme : Postdoctoral Research Foundation of China
ID : 2021MD703799
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Nature B.V.
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