[
Animals
Humans
Mice
Alzheimer Disease
/ pathology
Amyloid beta-Peptides
/ metabolism
Brain
/ metabolism
Cross-Sectional Studies
Gliosis
/ pathology
Inflammation
/ metabolism
Mice, Transgenic
Monoamine Oxidase
/ metabolism
Neurodegenerative Diseases
/ metabolism
Oligodendroglioma
/ metabolism
Pilot Projects
Positron-Emission Tomography
/ methods
Receptors, GABA
/ metabolism
Astrocytes
Deprenyl
MAO-B
PET
Journal
Journal of neuroinflammation
ISSN: 1742-2094
Titre abrégé: J Neuroinflammation
Pays: England
ID NLM: 101222974
Informations de publication
Date de publication:
11 Mar 2023
11 Mar 2023
Historique:
received:
07
11
2022
accepted:
23
02
2023
entrez:
11
3
2023
pubmed:
13
3
2023
medline:
15
3
2023
Statut:
epublish
Résumé
Reactive gliosis is a common pathological hallmark of CNS pathology resulting from neurodegeneration and neuroinflammation. In this study we investigate the capability of a novel monoamine oxidase B (MAO-B) PET ligand to monitor reactive astrogliosis in a transgenic mouse model of Alzheimer`s disease (AD). Furthermore, we performed a pilot study in patients with a range of neurodegenerative and neuroinflammatory conditions. A cross-sectional cohort of 24 transgenic (PS2APP) and 25 wild-type mice (age range: 4.3-21.0 months) underwent 60 min dynamic [ We selected the cerebellum as a pseudo-reference region based on the immunohistochemical comparison of age-matched PS2APP and WT mice. Subsequent PET imaging revealed that PS2APP mice showed elevated hippocampal and thalamic [ [
Identifiants
pubmed: 36906584
doi: 10.1186/s12974-023-02749-2
pii: 10.1186/s12974-023-02749-2
pmc: PMC10007845
doi:
Substances chimiques
Amyloid beta-Peptides
0
Monoamine Oxidase
EC 1.4.3.4
Receptors, GABA
0
TSPO protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
68Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : EXC 2145 SyNergy - ID 390857198
Informations de copyright
© 2023. The Author(s).
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