Evaluation of the bisphenol A-induced vascular toxicity on human umbilical artery.
Calcium channels
Endocrine-disrupting chemical
Guanyl cyclase
Molecular docking
Potassium channels
Pregnancy exposome
Journal
Environmental research
ISSN: 1096-0953
Titre abrégé: Environ Res
Pays: Netherlands
ID NLM: 0147621
Informations de publication
Date de publication:
01 06 2023
01 06 2023
Historique:
received:
23
12
2021
revised:
02
02
2023
accepted:
04
03
2023
medline:
17
4
2023
pubmed:
13
3
2023
entrez:
12
3
2023
Statut:
ppublish
Résumé
Bisphenol A (BPA) is one of the most widely used synthetic compound in the manufacture of polycarbonate plastics and epoxy resins. Worryingly, BPA is an endocrine disrupting chemical (EDC) with an estrogenic, androgenic, or anti-androgenic activities. However, the vascular implications of BPA exposome in pregnancy is unclear. In this sense, the present work proposed to understand how BPA exposure impair the vasculature of the pregnant women. To elucidate this, ex vivo studies were performed using human umbilical arteries to explore the acute and chronic effects of BPA. The mode of action of BPA was also explored by analysing the activity (by ex vivo studies) and expression (in vitro studies) analysis of Ca
Identifiants
pubmed: 36907341
pii: S0013-9351(23)00420-6
doi: 10.1016/j.envres.2023.115628
pii:
doi:
Substances chimiques
bisphenol A
MLT3645I99
Phenols
0
Benzhydryl Compounds
0
Endocrine Disruptors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
115628Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.