Hematopoietic Stem Cell Transplantation in Thalassemia.

Humans Quality of Life Transplantation, Homologous / adverse effects Hematopoietic Stem Cell Transplantation / methods Thalassemia / therapy Graft vs Host Disease Transplantation Conditioning / methods Unrelated Donors
Cord blood transplantation Haploidentical transplantation Hematopoietic stem cell transplantation Hemoglobinopathies Sibling donor transplantation Thalassemia Unrelated donor transplantation

Journal

Hematology/oncology clinics of North America
ISSN: 1558-1977
Titre abrégé: Hematol Oncol Clin North Am
Pays: United States
ID NLM: 8709473

Informations de publication

Date de publication:
04 2023
Historique:
entrez: 12 3 2023
pubmed: 13 3 2023
medline: 15 3 2023
Statut: ppublish

Résumé

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only consolidated, potentially curative treatment for patients with transfusion-dependent thalassemia major. In the past few decades, several new approaches have reduced the toxicity of conditioning regimens and decreased the incidence of graft-versus-host disease, improving patients' outcomes and quality of life. In addition, the progressive availability of alternative stem cell sources from unrelated or haploidentical donors or umbilical cord blood has made HSCT a feasible option for an increasing number of subjects lacking an human leukocyte antigen (HLA)-identical sibling. This review provides an overview of allogeneic hematopoietic stem cell transplantation in thalassemia, reassesses current clinical results, and discusses future perspectives.

Identifiants

DOI: 10.1016/j.hoc.2022.12.009 PMID: 36907612
pubmed: 36907612
pii: S0889-8588(22)00150-2
doi: 10.1016/j.hoc.2022.12.009
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

413-432

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Auteurs

Mattia Algeri (M)

Department of Hematology/Oncology, Cell and Gene Therapy - IRCCS, Bambino Gesù Children's Hospital, Rome, Italy. Electronic address: mattia.algeri@opbg.net.

Mariachiara Lodi (M)

Department of Hematology/Oncology, Cell and Gene Therapy - IRCCS, Bambino Gesù Children's Hospital, Rome, Italy.

Franco Locatelli (F)

Department of Hematology/Oncology, Cell and Gene Therapy - IRCCS, Bambino Gesù Children's Hospital, Rome, Italy; Department of Life Sciences and Public Health, Catholic University of the Sacred Heart, Rome, Italy.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Hematopoietic Stem Cell Transplantation in Thalassemia.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Démographie › État de santé › Qualité de vie › Hematopoietic Stem Cell Transplantation in Thalassemia.
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation homologue › Hematopoietic Stem Cell Transplantation in Thalassemia.
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation cellulaire › Transplantation de cellules souches › Transplantation de cellules souches hématopoïétiques › Hematopoietic Stem Cell Transplantation in Thalassemia.
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Maladies génétiques congénitales › Hémoglobinopathies › Thalassémie › Hematopoietic Stem Cell Transplantation in Thalassemia.
questionsmedicales.fr › Maladies du système immunitaire › Maladie du greffon contre l'hôte › Hematopoietic Stem Cell Transplantation in Thalassemia.
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Immunosuppression thérapeutique › Conditionnement pour greffe › Hematopoietic Stem Cell Transplantation in Thalassemia.
questionsmedicales.fr › Personnes › Donneurs de tissus › Donneurs non apparentés › Hematopoietic Stem Cell Transplantation in Thalassemia.