Liraglutide Lowers Endothelial Vascular Cell Adhesion Molecule-1 in Murine Atherosclerosis Independent of Glucose Levels.
ApoE, apolipoprotein E
CEUMI, contrast-enhanced ultrasound molecular imaging
CVD, cardiovascular disease
GLP, glucagon-like peptide
GLP-1R, glucagon-like peptide-1 receptor
GLP-1RA, glucagon-like peptide-1 receptor agonist
HDL-C, high-density lipoprotein cholesterol
HbA1c, glycated hemoglobin
ICAM, intercellular cell adhesion molecule
IL, interleukin
LDL-C, low-density lipoprotein cholesterol
MB, microbubble
MBCtr, control microbubbles
MBVCAM-1, microbubbles targeted to VCAM
MCP, monocyte chemoattractant protein
OPN, osteopontin
TG, triglycerides
TGRL, triglyceride-rich lipoproteins
TNF, tumor necrosis factor
VCAM, vascular cell adhesion molecule
VLDL-C, very low-density lipoprotein cholesterol
atherosclerosis
liraglutide
molecular imaging
ultrasound
Journal
JACC. Basic to translational science
ISSN: 2452-302X
Titre abrégé: JACC Basic Transl Sci
Pays: United States
ID NLM: 101677259
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
received:
14
03
2022
revised:
02
08
2022
accepted:
02
08
2022
entrez:
13
3
2023
pubmed:
14
3
2023
medline:
14
3
2023
Statut:
epublish
Résumé
The authors determined the effect of the GLP-1 receptor agonist liraglutide on endothelial surface expression of vascular cell adhesion molecule (VCAM)-1 in murine apolipoprotein E knockout atherosclerosis. Contrast-enhanced ultrasound molecular imaging using microbubbles targeted to VCAM-1 and control microbubbles showed a 3-fold increase in endothelial surface VCAM-1 signal in vehicle-treated animals, whereas in the liraglutide-treated animals the signal ratio remained around 1 throughout the study. Liraglutide had no influence on low-density lipoprotein cholesterol or glycated hemoglobin, but reduced TNF-α, IL-1β, MCP-1, and OPN. Aortic plaque lesion area and luminal VCAM-1 expression on immunohistology were reduced under liraglutide treatment.
Identifiants
pubmed: 36908664
doi: 10.1016/j.jacbts.2022.08.002
pii: S2452-302X(22)00302-3
pmc: PMC9998474
doi:
Types de publication
Journal Article
Langues
eng
Pagination
189-200Informations de copyright
© 2023 The Authors.
Déclaration de conflit d'intérêts
This work is supported by grants 310030-169905 and 310030-197673 from the Swiss national Science Foundation and from the Swiss Heart Foundation to Dr Kaufmann. This work was funded in part by Novo Nordisk A/S, Bagsværd, Denmark. The authors have reported that they have no relationships relevant to the contents of this paper to disclose.
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