Mechanisms of the "No-Reflow" Phenomenon After Acute Myocardial Infarction: Potential Role of Pericytes.
CHP, capillary hydrostatic pressure
MBF, myocardial blood flow
MCE, myocardial contrast echocardiography
NG2, neural glial antigen-2
acute myocardial infarction
blood flow
necrosis
no reflow
pericytes
Journal
JACC. Basic to translational science
ISSN: 2452-302X
Titre abrégé: JACC Basic Transl Sci
Pays: United States
ID NLM: 101677259
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
received:
20
05
2022
revised:
13
06
2022
accepted:
13
06
2022
entrez:
13
3
2023
pubmed:
14
3
2023
medline:
14
3
2023
Statut:
epublish
Résumé
Pericytes contract during myocardial ischemia resulting in capillary constriction and no reflow. Reversing pericyte contraction pharmacologically reduces no reflow and infarct size. These findings open up an entire new venue of research aimed at altering pericyte function in myocardial ischemia and infarction.
Identifiants
pubmed: 36908667
doi: 10.1016/j.jacbts.2022.06.008
pii: S2452-302X(22)00228-5
pmc: PMC9998747
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
204-220Informations de copyright
© 2023 The Authors.
Déclaration de conflit d'intérêts
Supported by the Garthe and Grace L. Brown Fund of the Oregon Community Foundation. Dr Kaul is one of several inventors mentioned in a provisional patent, filed by Oregon Health and Science University, in the United States for developing drugs to inhibit GPR39;. and he has financial interest in a company (Vasocardea) that has a provisional license from Oregon Health and Science University to commercialize any drugs developed under the patent. A final licensing agreement has not yet been executed. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
Références
J Am Coll Cardiol. 1997 Apr;29(5):1081-8
pubmed: 9120163
Lancet. 2008 Jun 7;371(9628):1889-90
pubmed: 18539205
J Am Coll Cardiol. 2008 Oct 21;52(17):1391-8
pubmed: 18940529
J Am Soc Echocardiogr. 2020 Feb;33(2):234-246
pubmed: 31812549
Front Cardiovasc Med. 2022 Jun 24;9:930492
pubmed: 35811707
Basic Res Cardiol. 1982 Mar-Apr;77(2):170-81
pubmed: 7092775
Am Heart J. 2004 Oct;148(4):E15
pubmed: 15459610
N Engl J Med. 2007 Jun 7;356(23):2388-98
pubmed: 17554120
Nat Med. 2009 Sep;15(9):1031-7
pubmed: 19718040
J Cardiovasc Pharmacol. 2000 Jun;35(6):919-25
pubmed: 10836727
JAMA. 2009 Aug 19;302(7):767-73
pubmed: 19690309
Circulation. 2018 May 1;137(18):1949-1964
pubmed: 29712696
J Clin Invest. 1976 May;57(5):1359-68
pubmed: 1262476
Circulation. 1989 Dec;80(6):1846-61
pubmed: 2598442
Cardiovasc Drugs Ther. 2019 Oct;33(5):589-597
pubmed: 31418141
Biosci Rep. 2017 Jul 27;37(4):
pubmed: 28667102
Exp Eye Res. 1988 Mar;46(3):349-62
pubmed: 3258246
Cardiovasc Drugs Ther. 2016 Dec;30(6):559-566
pubmed: 27747447
Circulation. 1992 May;85(5):1942-4
pubmed: 1572050
J Phys Condens Matter. 2010 May 19;22(19):194115
pubmed: 21386441
Circulation. 1998 Feb 10;97(5):473-83
pubmed: 9490243
J Pathol Bacteriol. 1959 Jul;78:105-20
pubmed: 14445715
Circ Res. 1989 Jan;64(1):86-96
pubmed: 2909304
J Am Coll Cardiol. 2013 Oct 15;62(16):1409-18
pubmed: 23665372
Anat Rec. 2000 Nov 1;260(3):299-307
pubmed: 11066040
J Clin Invest. 1974 Dec;54(6):1496-508
pubmed: 4140198
Am J Physiol. 1999 Dec;277(6):H2363-72
pubmed: 10600857
Am J Physiol. 1985 Mar;248(3 Pt 2):H403-11
pubmed: 3156514
J Am Coll Cardiol. 1997 Nov 1;30(5):1193-9
pubmed: 9350914
Acta Neuropathol Commun. 2019 Aug 20;7(1):134
pubmed: 31429795
Am J Physiol Heart Circ Physiol. 2017 Nov 1;313(5):H871-H878
pubmed: 28778913
Circulation. 2001 Nov 13;104(20):2471-7
pubmed: 11705827
Nat Commun. 2020 Jan 20;11(1):395
pubmed: 31959752
Circulation. 1993 Dec;88(6):2596-606
pubmed: 8252670
Int J Cardiol. 2016 Dec 1;224:90-95
pubmed: 27643472
Proc Natl Acad Sci U S A. 2020 Oct 27;117(43):27022-27033
pubmed: 33051294
Cardiovasc Res. 2005 Jun 1;66(3):552-61
pubmed: 15914120
Am J Pathol. 1948 May;24(3):625-41
pubmed: 18859362
J Cardiothorac Vasc Anesth. 2007 Jun;21(3):337-43
pubmed: 17544883
Neurophotonics. 2015 Oct;2(4):041402
pubmed: 26158016
Am J Physiol. 1985 Sep;249(3 Pt 2):H638-47
pubmed: 4037109
Am J Physiol Heart Circ Physiol. 2021 Dec 1;321(6):H1030-H1041
pubmed: 34623177
Circ Res. 1975 Jun;36(6):771-81
pubmed: 1132070
Am J Cardiol. 2002 Nov 18;90(10A):8J-14J
pubmed: 12450584
Curr Tissue Microenviron Rep. 2020 Dec;1(4):163-169
pubmed: 33778770
JAMA. 2005 Mar 2;293(9):1063-72
pubmed: 15741528
J Cardiovasc Pharmacol Ther. 2008 Sep;13(3):226-32
pubmed: 18625805
Am J Physiol. 1997 Jan;272(1 Pt 2):H567-75
pubmed: 9038980
Nature. 2014 Apr 3;508(7494):55-60
pubmed: 24670647
Invest Ophthalmol Vis Sci. 1997 Dec;38(13):2695-701
pubmed: 9418721
Am J Physiol Cell Physiol. 2022 May 1;322(5):C1011-C1021
pubmed: 35385329
J Physiol. 1896 May 5;19(4):312-26
pubmed: 16992325
Brain Res. 2001 Jul 13;907(1-2):93-9
pubmed: 11430889
J Am Coll Cardiol. 2006 Jul 18;48(2):244-52
pubmed: 16843170
Vasc Biol. 2019 Apr 25;1(1):H23-H31
pubmed: 32923950
J Cardiol. 2014 Aug;64(2):77-85
pubmed: 24799155
J Am Coll Cardiol. 2008 Oct 21;52(17):1399-401
pubmed: 18940530
Heart. 2004 Oct;90(10):1199-205
pubmed: 15367524
Pflugers Arch. 2013 Jun;465(6):779-87
pubmed: 23443852
J Am Coll Cardiol. 1999 Mar;33(3):654-60
pubmed: 10080465
Mol Cell Biochem. 2022 Jul;477(7):1921-1929
pubmed: 35347547
Front Immunol. 2018 May 23;9:1002
pubmed: 29875766
J Cell Biol. 1987 Mar;104(3):483-90
pubmed: 3818789
Circ Res. 1990 Nov;67(5):1201-10
pubmed: 2225354
Circulation. 2015 Feb 10;131(6):550-9
pubmed: 25552356
Am J Pathol. 1968 Feb;52(2):437-53
pubmed: 5635861
Am J Physiol Heart Circ Physiol. 2019 Aug 1;317(2):H255-H263
pubmed: 31125259
Circulation. 1996 Aug 15;94(4):748-54
pubmed: 8772698
Circ Res. 1966 Jul;19(1):57-62
pubmed: 5912914
Am J Physiol Heart Circ Physiol. 2018 Sep 1;315(3):H550-H562
pubmed: 29882685
Front Cell Neurosci. 2020 Dec 18;14:601324
pubmed: 33390906
Prog Cardiovasc Dis. 1977 Jul-Aug;20(1):55-79
pubmed: 877305
Circulation. 1985 Feb;71(2):370-7
pubmed: 3965177
Microvasc Res. 1969 Apr;1(3):244-56
pubmed: 5406306
Circulation. 2008 Jul 15;118(3):291-308
pubmed: 18625905
Am J Cardiol. 2004 Jul 1;94(1):35-9
pubmed: 15219505
Lancet. 2008 Jun 7;371(9628):1915-20
pubmed: 18539223
Front Neurosci. 2019 Dec 05;13:1306
pubmed: 31866815
Arch Histol Cytol. 2000 May;63(2):115-26
pubmed: 10885448
Circulation. 1988 Aug;78(2):462-72
pubmed: 2456169
Am J Physiol Heart Circ Physiol. 2001 Apr;280(4):H1660-6
pubmed: 11247777
J Am Heart Assoc. 2013 Jan 04;2(1):e004234
pubmed: 23525431
Circulation. 2008 Jul 1;118(1):49-57
pubmed: 18559698
Am J Anat. 1979 Dec;156(4):523-31
pubmed: 160753
Circulation. 1977 Nov;56(5):786-94
pubmed: 912839
Elife. 2017 Nov 09;6:
pubmed: 29120327
Circulation. 2000 May 9;101(18):2154-9
pubmed: 10801755
Circ Res. 1994 Jun;74(6):1157-65
pubmed: 8187282
PLoS One. 2016 Sep 07;11(9):e0162425
pubmed: 27603665
J Am Coll Cardiol. 2005 Jun 7;45(11):1775-80
pubmed: 15936605
J Am Heart Assoc. 2022 Jan 4;11(1):e021682
pubmed: 34935456
Catheter Cardiovasc Interv. 2008 Feb 15;71(3):283-9
pubmed: 17985384
Basic Res Cardiol. 2015 Mar;110(2):1
pubmed: 25589055
Handb Exp Pharmacol. 2009;(193):189-214
pubmed: 19639283
Mol Med Rep. 2018 Jan;17(1):580-585
pubmed: 29115615
Circ Res. 1989 Aug;65(2):458-67
pubmed: 2752551
Am J Physiol Heart Circ Physiol. 2020 Jan 1;318(1):H189-H202
pubmed: 31834840
J Neurosci. 2016 Sep 7;36(36):9435-45
pubmed: 27605617
Nat Neurosci. 2016 Dec;19(12):1619-1627
pubmed: 27775719
Anat Rec. 1982 Feb;202(2):187-91
pubmed: 7065419
J Pathol Bacteriol. 1966 Jan;91(1):235-40
pubmed: 5941393