Hereditary cancer syndromes.
Cancer predisposition
Cancer treatment
Germline pathogenic variants
Hereditary cancer syndromes
Next-generation sequencing
Journal
World journal of clinical oncology
ISSN: 2218-4333
Titre abrégé: World J Clin Oncol
Pays: United States
ID NLM: 101549149
Informations de publication
Date de publication:
24 Feb 2023
24 Feb 2023
Historique:
received:
17
11
2022
revised:
09
12
2022
accepted:
14
02
2023
entrez:
13
3
2023
pubmed:
14
3
2023
medline:
14
3
2023
Statut:
ppublish
Résumé
Hereditary cancer syndromes (HCSs) are arguably the most frequent category of Mendelian genetic diseases, as at least 2% of presumably healthy subjects carry highly-penetrant tumor-predisposing pathogenic variants (PVs). Hereditary breast-ovarian cancer and Lynch syndrome make the highest contribution to cancer morbidity; in addition, there are several dozen less frequent types of familial tumors. The development of the majority albeit not all hereditary malignancies involves two-hit mechanism,
Identifiants
pubmed: 36908677
doi: 10.5306/wjco.v14.i2.40
pmc: PMC9993141
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
40-68Informations de copyright
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
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