Malignant Hypercalcemia Induced by the Ectopic Production of Intact Parathyroid Hormone (PTH).
ectopic malignant hyperparathyroidism
ectopic pth production
intact parathyroid hormone
malignant hypercalcemia
small cell lung cancer
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
accepted:
08
02
2023
entrez:
13
3
2023
pubmed:
14
3
2023
medline:
14
3
2023
Statut:
epublish
Résumé
Malignant hypercalcemia is a common finding in patients with advanced cancer, involving mechanisms like tumor secretion of parathyroid hormone (PTH)-related protein, osteolytic metastases, and tumor production of calcitriol. Although rare, hypercalcemia induced by ectopic tumoral secretion of PTH can be an additional mechanism. Here we present an 84-year-old male patient who was admitted to the hospital with a non-productive cough, anorexia, and a single episode of small-volume hemoptysis. He was diagnosed with stage T4N3M1c left lung small cell carcinoma, and laboratory tests were remarkable for elevated ionized calcium as well as elevated serum intact PTH. A parathyroid 99mTc sestamibi scan showed no changes, suggesting ectopic production of PTH. Being a rare event, malignant hypercalcemia from intact PTH ectopic production should be considered in these patients.
Identifiants
pubmed: 36909108
doi: 10.7759/cureus.34770
pmc: PMC10001420
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e34770Informations de copyright
Copyright © 2023, Neves et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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