Leveraging IFNγ/CD38 regulation to unmask and target leukemia stem cells in acute myelogenous leukemia.

CD38 acute myeloid leukemia bispecific T cell engagers interferon gamma leukemia stem cells

Journal

bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187

Informations de publication

Date de publication:
01 Mar 2023
Historique:
pubmed: 14 3 2023
medline: 14 3 2023
entrez: 13 3 2023
Statut: epublish

Résumé

Elimination of drug-resistant leukemia stem cells (LSCs) represents a major challenge to achieve a cure in acute myeloid leukemia (AML). Although AML blasts generally retain high levels of surface CD38 (CD38

Identifiants

DOI: 10.1101/2023.02.27.530273 PMID: 36909542 PMC: PMC10002674
pubmed: 36909542
doi: 10.1101/2023.02.27.530273
pmc: PMC10002674
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : NCI NIH HHS
ID : R50 CA252135
Pays : United States

Déclaration de conflit d'intérêts

Conflict of interest: The authors declare no relevant conflicts of interest.

Auteurs

Mariam Murtadha (M)

Judy and Bernard Briskin Center for Multiple Myeloma Research, Department of Hematology and Hematopoietic Cell Transplantation, City of Hope; Duarte, CA, USA.
Department of Hematologic Malignancies Translational Science, Beckman Research Institute, City of Hope; Duarte, CA, USA.

Miso Park (M)

Department of Molecular Medicine, Beckman Research Institute, City of Hope; Duarte, CA, USA.

Yinghui Zhu (Y)

Judy and Bernard Briskin Center for Multiple Myeloma Research, Department of Hematology and Hematopoietic Cell Transplantation, City of Hope; Duarte, CA, USA.
Department of Hematologic Malignancies Translational Science, Beckman Research Institute, City of Hope; Duarte, CA, USA.

Enrico Caserta (E)

Judy and Bernard Briskin Center for Multiple Myeloma Research, Department of Hematology and Hematopoietic Cell Transplantation, City of Hope; Duarte, CA, USA.
Department of Hematologic Malignancies Translational Science, Beckman Research Institute, City of Hope; Duarte, CA, USA.

Ada Alice Dona (AA)

Judy and Bernard Briskin Center for Multiple Myeloma Research, Department of Hematology and Hematopoietic Cell Transplantation, City of Hope; Duarte, CA, USA.
Department of Hematologic Malignancies Translational Science, Beckman Research Institute, City of Hope; Duarte, CA, USA.

Mahmoud Singer (M)

Judy and Bernard Briskin Center for Multiple Myeloma Research, Department of Hematology and Hematopoietic Cell Transplantation, City of Hope; Duarte, CA, USA.
Department of Hematologic Malignancies Translational Science, Beckman Research Institute, City of Hope; Duarte, CA, USA.

Hawa Vahed (H)

Judy and Bernard Briskin Center for Multiple Myeloma Research, Department of Hematology and Hematopoietic Cell Transplantation, City of Hope; Duarte, CA, USA.
Department of Hematologic Malignancies Translational Science, Beckman Research Institute, City of Hope; Duarte, CA, USA.

Theophilus Tasndoh (T)

Judy and Bernard Briskin Center for Multiple Myeloma Research, Department of Hematology and Hematopoietic Cell Transplantation, City of Hope; Duarte, CA, USA.
Department of Hematologic Malignancies Translational Science, Beckman Research Institute, City of Hope; Duarte, CA, USA.

Asaul Gonzalez (A)

Department of Molecular Medicine, Beckman Research Institute, City of Hope; Duarte, CA, USA.

Kevin Ly (K)

Department of Molecular Medicine, Beckman Research Institute, City of Hope; Duarte, CA, USA.

James F Sanchez (JF)

Judy and Bernard Briskin Center for Multiple Myeloma Research, Department of Hematology and Hematopoietic Cell Transplantation, City of Hope; Duarte, CA, USA.

Arnab Chowdhury (A)

Judy and Bernard Briskin Center for Multiple Myeloma Research, Department of Hematology and Hematopoietic Cell Transplantation, City of Hope; Duarte, CA, USA.
Department of Computational and Quantitative Medicine, Beckman Research Institute, City of Hope; Duarte, CA, USA.

Alex Pozhitkov (A)

Judy and Bernard Briskin Center for Multiple Myeloma Research, Department of Hematology and Hematopoietic Cell Transplantation, City of Hope; Duarte, CA, USA.
Department of Hematologic Malignancies Translational Science, Beckman Research Institute, City of Hope; Duarte, CA, USA.

Lucy Ghoda (L)

Department of Hematologic Malignancies Translational Science, Beckman Research Institute, City of Hope; Duarte, CA, USA.

Ling Li (L)

Department of Hematologic Malignancies Translational Science, Beckman Research Institute, City of Hope; Duarte, CA, USA.

Bin Zhang (B)

Department of Hematologic Malignancies Translational Science, Beckman Research Institute, City of Hope; Duarte, CA, USA.

Amrita Krishnan (A)

Judy and Bernard Briskin Center for Multiple Myeloma Research, Department of Hematology and Hematopoietic Cell Transplantation, City of Hope; Duarte, CA, USA.

Guido Marcucci (G)

Department of Hematologic Malignancies Translational Science, Beckman Research Institute, City of Hope; Duarte, CA, USA.

John Williams (J)

Department of Molecular Medicine, Beckman Research Institute, City of Hope; Duarte, CA, USA.

Flavia Pichiorri (F)

Judy and Bernard Briskin Center for Multiple Myeloma Research, Department of Hematology and Hematopoietic Cell Transplantation, City of Hope; Duarte, CA, USA.
Department of Hematologic Malignancies Translational Science, Beckman Research Institute, City of Hope; Duarte, CA, USA.

Classifications MeSH