Recipient, donor, and surgical factors leading to primary graft dysfunction after lung transplant.
Primary graft dysfunction
lung transplantation
risk factor
Journal
Journal of thoracic disease
ISSN: 2072-1439
Titre abrégé: J Thorac Dis
Pays: China
ID NLM: 101533916
Informations de publication
Date de publication:
28 Feb 2023
28 Feb 2023
Historique:
received:
13
07
2022
accepted:
05
12
2022
entrez:
13
3
2023
pubmed:
14
3
2023
medline:
14
3
2023
Statut:
ppublish
Résumé
Primary graft dysfunction is a major cause of early mortality following lung transplantation. The International Society for Heart and Lung Transplantation subdivides it into 4 grades of increasing severity. A retrospective review of the institutional lung transplant database from March 2018 to September 2021 was performed. Patients were stratified into three groups: primary graft dysfunction grade 0 patients, grade 1 or 2 patients, and grade 3 patients. Recipient, donor, and surgical variables were analyzed by logistic regression analysis to identify risk factors for primary graft dysfunction grade 1 or 2 and grade 3. Primary graft dysfunction grade 1 to 3 occurred in 45.0% of the cohort (n=68) of whom 33.3% (n=23) had primary graft dysfunction grade 3. Longer operative time was more common in primary graft dysfunction grade 1 to 3 patients (P<0.001). The 1-year survival of the patients with primary graft dysfunction grade 3 was lower than the others (grade 0-2 The calculated predictors of primary graft dysfunction grade 1 or 2 were similar to those of primary graft dysfunction grade 3.
Sections du résumé
Background
UNASSIGNED
Primary graft dysfunction is a major cause of early mortality following lung transplantation. The International Society for Heart and Lung Transplantation subdivides it into 4 grades of increasing severity.
Methods
UNASSIGNED
A retrospective review of the institutional lung transplant database from March 2018 to September 2021 was performed. Patients were stratified into three groups: primary graft dysfunction grade 0 patients, grade 1 or 2 patients, and grade 3 patients. Recipient, donor, and surgical variables were analyzed by logistic regression analysis to identify risk factors for primary graft dysfunction grade 1 or 2 and grade 3.
Results
UNASSIGNED
Primary graft dysfunction grade 1 to 3 occurred in 45.0% of the cohort (n=68) of whom 33.3% (n=23) had primary graft dysfunction grade 3. Longer operative time was more common in primary graft dysfunction grade 1 to 3 patients (P<0.001). The 1-year survival of the patients with primary graft dysfunction grade 3 was lower than the others (grade 0-2
Conclusions
UNASSIGNED
The calculated predictors of primary graft dysfunction grade 1 or 2 were similar to those of primary graft dysfunction grade 3.
Identifiants
pubmed: 36910052
doi: 10.21037/jtd-22-974
pii: jtd-15-02-399
pmc: PMC9992558
doi:
Types de publication
Journal Article
Langues
eng
Pagination
399-409Subventions
Organisme : NIAID NIH HHS
ID : T32 AI083216
Pays : United States
Informations de copyright
2023 Journal of Thoracic Disease. All rights reserved.
Déclaration de conflit d'intérêts
Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://jtd.amegroups.com/article/view/10.21037/jtd-22-974/coif). AB is supported by National Institutes of Health (No. HL145478, HL147290, and HL147575). The other authors have no conflicts of interest to declare.
Références
J Thorac Cardiovasc Surg. 2015 Feb;149(2):596-602
pubmed: 25439478
Ann Thorac Surg. 2020 Oct;110(4):1209-1215
pubmed: 32173339
Gen Thorac Cardiovasc Surg. 2018 Jan;66(1):38-47
pubmed: 28918471
Eur J Cardiothorac Surg. 2007 Jan;31(1):75-82
pubmed: 17134909
J Heart Lung Transplant. 2016 Jul;35(7):947-8
pubmed: 27235267
Am J Transplant. 2011 Nov;11(11):2517-22
pubmed: 21883907
Am J Transplant. 2007 Mar;7(3):700-6
pubmed: 17250560
J Thorac Dis. 2016 Nov;8(11):3275-3282
pubmed: 28066607
J Heart Lung Transplant. 2017 Oct;36(10):1097-1103
pubmed: 28942784
Am J Transplant. 2016 Mar;16(3):833-40
pubmed: 26663441
J Thorac Cardiovasc Surg. 2011 Jan;141(1):215-22
pubmed: 21093882
Clin Transplant. 2009 Nov-Dec;23(6):819-30
pubmed: 19239481
Chest. 2011 Apr;139(4):782-787
pubmed: 20864607
Crit Care Med. 2018 Nov;46(11):e1070-e1073
pubmed: 30095500
PLoS One. 2014 Mar 21;9(3):e92773
pubmed: 24658073
J Heart Lung Transplant. 2005 Oct;24(10):1454-9
pubmed: 16210116
Am J Respir Crit Care Med. 2012 Sep 15;186(6):546-52
pubmed: 22822025
Am J Respir Crit Care Med. 2007 Mar 1;175(5):507-13
pubmed: 17158279
Am J Respir Crit Care Med. 2013 Mar 1;187(5):527-34
pubmed: 23306540
Bone Marrow Transplant. 2013 Mar;48(3):452-8
pubmed: 23208313
J Heart Lung Transplant. 2015 Jul;34(7):941-9
pubmed: 25935436
J Thorac Cardiovasc Surg. 2006 Jan;131(1):73-80
pubmed: 16399297
Chest. 2003 Oct;124(4):1232-41
pubmed: 14555551
Crit Care. 2004 Aug;8(4):R204-12
pubmed: 15312219
Am J Respir Crit Care Med. 2014 Mar 1;189(5):567-75
pubmed: 24467603
JAMA. 2022 Feb 15;327(7):652-661
pubmed: 35085383
Am J Transplant. 2008 Nov;8(11):2454-62
pubmed: 18785961
Transplant Proc. 2012 Oct;44(8):2462-8
pubmed: 23026621