The utility of TLE1 and BCOR as immunohistochemical markers for angiomatoid fibrous histiocytoma.
Angiomatoid fibrous histiocytoma
BCOR
TLE1
immunohistochemical staining
pitfalls
utility
Journal
International journal of clinical and experimental pathology
ISSN: 1936-2625
Titre abrégé: Int J Clin Exp Pathol
Pays: United States
ID NLM: 101480565
Informations de publication
Date de publication:
2023
2023
Historique:
received:
02
12
2022
accepted:
13
02
2023
entrez:
13
3
2023
pubmed:
14
3
2023
medline:
14
3
2023
Statut:
epublish
Résumé
Diagnosis of angiomatoid fibrous histiocytoma (AFH) can be challenging due to its variable histologic features and a lack of highly sensitive and/or specific immunohistochemical markers. The utility of TLE1 and BCOR as immunohistochemical markers for AFH is not known. We examined the spectrum of histologic features of 36 AFHs, and studied the expression of both TLE1 and BCOR in AFH and its mimics by immunohistochemical staining. Positive nuclear expression was scored semiquantitatively. Both typical and unusual histologic features of AFHs were observed in this cohort. TLE1 was moderately to strongly positive in 36/36 AFHs, 4/4 synovial sarcomas, and 2/3 BCOR sarcomas; weakly positive in 4/6 inflammatory myofibroblastic tumors; negative in all dermatofibromas (n = 10), atypical fibrous histiocytomas (n = 5), myofibroma (n = 2) and juvenile xanthogranulomas (n = 5), with an overall sensitivity of 100%, and specificity of 71.4% for AFH. BCOR was moderately to strongly positive in 24/36 AFHs, 4/4 synovial sarcomas, 3/3 BCOR sarcomas, and 1/5 atypical fibrous histiocytomas; weakly positive in 10/36 AFHs; negative in the remaining tumors. The overall sensitivity and specificity of BCOR for AFH were 94.4% and 77.1%, respectively. TLE1 is a highly sensitive immunohistochemical marker for AFH.
Types de publication
Journal Article
Langues
eng
Pagination
32-39Informations de copyright
IJCEP Copyright © 2023.
Déclaration de conflit d'intérêts
None.
Références
Appl Immunohistochem Mol Morphol. 2019 Jan;27(1):e1-e4
pubmed: 28248724
J Clin Pathol. 2014 Mar;67(3):210-5
pubmed: 24043718
Arch Pathol Lab Med. 2015 May;139(5):674-82
pubmed: 25927151
Am J Surg Pathol. 2014 Jun;38(6):816-23
pubmed: 24503754
World Neurosurg. 2019 Jun;126:113-119
pubmed: 30831299
Pathology. 2014 Apr;46(3):199-204
pubmed: 24614712
J Clin Pathol. 2010 Feb;63(2):124-8
pubmed: 20154033
Am J Surg Pathol. 1990 Dec;14(12):1126-32
pubmed: 2174650
Sci Rep. 2021 Jan 26;11(1):2183
pubmed: 33500467
Ann Thorac Surg. 2001 Jul;72(1):283-5
pubmed: 11465207
BMC Musculoskelet Disord. 2017 Jan 23;18(1):31
pubmed: 28114920
Thorac Cancer. 2021 Feb;12(3):314-323
pubmed: 33314685
Genes Chromosomes Cancer. 2007 Dec;46(12):1051-60
pubmed: 17724745
Int J Clin Exp Pathol. 2015 Jan 01;8(1):772-8
pubmed: 25755773
Pediatr Dev Pathol. 2019 Oct;22(5):472-474
pubmed: 30823861
Cancer. 1979 Dec;44(6):2147-57
pubmed: 228836
Acta Derm Venereol. 2014 May;94(3):353-4
pubmed: 24002209
Pathology. 2020 Oct;52(6):722-725
pubmed: 32819737
Zhonghua Bing Li Xue Za Zhi. 2014 Jun;43(6):420-1
pubmed: 25208997
Mod Pathol. 2011 Dec;24(12):1560-70
pubmed: 21822206
Hum Pathol. 1999 Nov;30(11):1336-43
pubmed: 10571514
Pathologica. 2021 Apr;113(2):70-84
pubmed: 33179614
Am J Surg Pathol. 2016 Dec;40(12):1670-1678
pubmed: 27428733