GHRH-GH-IGF1 axis in pediatric Down syndrome: A systematic review and mini meta-analysis.
Down syndrome
IGF1
bio-inactive GH
growth hormone
hypothalamus
neurosecretory dysfunction
Journal
Frontiers in pediatrics
ISSN: 2296-2360
Titre abrégé: Front Pediatr
Pays: Switzerland
ID NLM: 101615492
Informations de publication
Date de publication:
2023
2023
Historique:
received:
27
12
2022
accepted:
06
02
2023
entrez:
13
3
2023
pubmed:
14
3
2023
medline:
14
3
2023
Statut:
epublish
Résumé
To analyze and determine the quality of functioning in different components of GHRH-GH-IGF1 axis in children with Down syndrome (DS). Systematic review and mini meta-analysis of the literature. A search was performed in PubMed, Embase, Scopus, and PsycINFO through August 2022. Eligible studies included pediatric patients with DS who had undergone any laboratory evaluation of the GHRH-GH-IGF1 axis. Two reviewers independently screened articles for eligibility. Results of each type of test were weighed together in patients both with and without DS and were pooled using a random effects meta-analysis. In total, 20 studies assessed the GHRH-GH-IGF1 axis function. A defect in three major components of GHRH-GH-IGF1 axis was found in a significant proportion of pediatric DS patients. A significant portion of short-stature pathogenesis in children with DS is associated with impaired GHRH-GH-IGF1 axis function.
Identifiants
pubmed: 36911030
doi: 10.3389/fped.2023.1132296
pmc: PMC9992742
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1132296Informations de copyright
© 2023 Shaki, Hershkovitz, Tamam, Bollotin, David, Yalovitsky, Loewenthal, Carmon, Walker and Haim.
Déclaration de conflit d'intérêts
The reviewer [H.W] declared a shared affiliation with the author [S.T] to the handling editor at the time of review.
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