Mechanosensitive pore opening of a prokaryotic voltage-gated sodium channel.
cell biology
electrophysiology
mechanosensitivity
molecular biophysics
patch-clamp
sodium channel
structural biology
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
13 03 2023
13 03 2023
Historique:
received:
05
04
2022
accepted:
10
03
2023
pubmed:
14
3
2023
medline:
28
3
2023
entrez:
13
3
2023
Statut:
epublish
Résumé
Voltage-gated ion channels (VGICs) orchestrate electrical activities that drive mechanical functions in contractile tissues such as the heart and gut. In turn, contractions change membrane tension and impact ion channels. VGICs are mechanosensitive, but the mechanisms of mechanosensitivity remain poorly understood. Here, we leverage the relative simplicity of NaChBac, a prokaryotic voltage-gated sodium channel from
Identifiants
pubmed: 36912788
doi: 10.7554/eLife.79271
pii: 79271
pmc: PMC10038658
doi:
pii:
Substances chimiques
Voltage-Gated Sodium Channels
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK052766
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM148239
Pays : United States
Organisme : NIDDK NIH HHS
ID : DK052766
Pays : United States
Organisme : NIDDK NIH HHS
ID : DK123549
Pays : United States
Organisme : NIH HHS
ID : AT010875
Pays : United States
Informations de copyright
© 2023, Strege et al.
Déclaration de conflit d'intérêts
PS, LC, CA, AM, CA, LM, GF, AB No competing interests declared
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