SOCS2 regulates alveolar bone loss in Aggregatibacter actinomycetemcomitans-induced periodontal disease.
Aggregatibacter actinomycetemcomitans
Immunoregulation
Osteoclastogenesis
Periodontitis
SOCS2
Journal
Inflammation research : official journal of the European Histamine Research Society ... [et al.]
ISSN: 1420-908X
Titre abrégé: Inflamm Res
Pays: Switzerland
ID NLM: 9508160
Informations de publication
Date de publication:
Apr 2023
Apr 2023
Historique:
received:
03
11
2022
accepted:
16
02
2023
revised:
19
12
2022
medline:
27
4
2023
pubmed:
14
3
2023
entrez:
13
3
2023
Statut:
ppublish
Résumé
The role of suppressor of cytokine signaling 2 (SOCS2) in Aggregatibacter actinomycetemcomitans (Aa)-induced alveolar bone loss is unknown; thus, it was investigated in this study. Alveolar bone loss was induced by infecting C57BL/6 wild-type (WT) and Socs2-knockout (Socs2 Socs2 Collectively, data suggest that SOCS2 is a regulator of Aa-induced alveolar bone loss by controlling the differentiation and activity of bone cells, and proinflammatory cytokines availability in the periodontal microenvironment and an important target for new therapeutic strategies. Thus, it can be helpful in preventing alveolar bone loss in periodontal inflammatory conditions.
Identifiants
pubmed: 36912916
doi: 10.1007/s00011-023-01711-5
pii: 10.1007/s00011-023-01711-5
doi:
Substances chimiques
Cytokines
0
Socs2 protein, mouse
0
Suppressor of Cytokine Signaling Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
859-873Subventions
Organisme : National Institute for Science and Technology in Dengue and Host-microbial interactions
ID : APQ-03606-17
Organisme : Fundação de Amparo a Pesquisa de Minas Gerais
ID : REDE-00140-16
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : 408433/2018-3
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : 307981/2014-2
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
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