α-Synuclein conformers reveal link to clinical heterogeneity of α-synucleinopathies.

Humans alpha-Synuclein / genetics Synucleinopathies / diagnosis Parkinson Disease / diagnosis Lewy Bodies / pathology Multiple System Atrophy / diagnosis
Protein strains RT-QuIC α-synuclein α-synucleinopathies

Journal

Translational neurodegeneration
ISSN: 2047-9158
Titre abrégé: Transl Neurodegener
Pays: England
ID NLM: 101591861

Informations de publication

Date de publication:
14 03 2023
Historique:
received: 21 11 2022
accepted: 13 02 2023
entrez: 14 3 2023
pubmed: 15 3 2023
medline: 16 3 2023
Statut: epublish

Résumé

α-Synucleinopathies, such as Parkinson's disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy, are a class of neurodegenerative diseases exhibiting intracellular inclusions of misfolded α-synuclein (αSyn), referred to as Lewy bodies or oligodendroglial cytoplasmic inclusions (Papp-Lantos bodies). Even though the specific cellular distribution of aggregated αSyn differs in PD and DLB patients, both groups show a significant pathological overlap, raising the discussion of whether PD and DLB are the same or different diseases. Besides clinical investigation, we will focus in addition on methodologies, such as protein seeding assays (real-time quaking-induced conversion), to discriminate between different types of α-synucleinopathies. This approach relies on the seeding conversion properties of misfolded αSyn, supporting the hypothesis that different conformers of misfolded αSyn may occur in different types of α-synucleinopathies. Understanding the pathological processes influencing the disease progression and phenotype, provoked by different αSyn conformers, will be important for a personalized medical treatment in future.

Identifiants

DOI: 10.1186/s40035-023-00342-4 PMID: 36915212 PMC: PMC10012698
pubmed: 36915212
doi: 10.1186/s40035-023-00342-4
pii: 10.1186/s40035-023-00342-4
pmc: PMC10012698
doi:

Substances chimiques

alpha-Synuclein 0

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

12

Informations de copyright

© 2023. The Author(s).

Références

Neurology. 2006 Jan 10;66(1):93-8
pubmed: 16401853
Eur J Neurol. 2009 Mar;16(3):297-309
pubmed: 19364361
Nat Med. 2008 May;14(5):504-6
pubmed: 18391962
Ann Neurol. 2019 May;85(5):691-703
pubmed: 30805957
Neurology. 2017 Jul 4;89(1):88-100
pubmed: 28592453
Ann Clin Transl Neurol. 2019 May 09;6(6):1024-1032
pubmed: 31211166
Brain. 2021 May 7;144(4):1118-1126
pubmed: 33855335
Annu Rev Genet. 2013;47:601-23
pubmed: 24274755
Protein Eng Des Sel. 2009 Aug;22(8):515-21
pubmed: 19570812
Nat Rev Neurosci. 2003 Jan;4(1):49-60
pubmed: 12511861
J Neuroimmune Pharmacol. 2019 Sep;14(3):423-435
pubmed: 30706414
Ann Clin Transl Neurol. 2021 Feb;8(2):374-384
pubmed: 33373501
Mov Disord. 2014 Jul;29(8):1010-8
pubmed: 24395122
JAMA Neurol. 2020 Sep 28;:
pubmed: 32986090
EMBO Mol Med. 2013 Jul;5(7):1119-27
pubmed: 23703938
Neurobiol Dis. 2011 Jun;42(3):360-7
pubmed: 21303699
NPJ Parkinsons Dis. 2021 Nov 15;7(1):99
pubmed: 34782640
Ann Neurol. 2019 May;85(5):777-781
pubmed: 30801759
J Exp Med. 2016 Aug 22;213(9):1759-78
pubmed: 27503075
Neurology. 2008 Aug 26;71(9):670-6
pubmed: 18725592
Mov Disord. 2007 Sep;22 Suppl 17:S351-7
pubmed: 18175396
Mov Disord. 2008 Dec 15;23(16):2303-6
pubmed: 19006193
Neurology. 2007 Mar 13;68(11):812-9
pubmed: 17353469
J Parkinsons Dis. 2017;7(s1):S71-S85
pubmed: 28282810
J Neural Transm (Vienna). 2011 May;118(5):713-9
pubmed: 21479514
FEBS Lett. 2001 Jun 8;498(2-3):204-7
pubmed: 11412858
Neurology. 2011 Aug 30;77(9):875-82
pubmed: 21849645
Lancet Neurol. 2021 Mar;20(3):203-212
pubmed: 33609478
Lancet Neurol. 2004 Jan;3(1):19-28
pubmed: 14693108
Acta Neuropathol Commun. 2021 Apr 7;9(1):62
pubmed: 33827706
Brain. 2012 Sep;135(Pt 9):2798-808
pubmed: 22961551
Nature. 2001 Jun 14;411(6839):810-3
pubmed: 11459061
Mov Disord. 2020 Dec;35(12):2230-2239
pubmed: 32960470
Alzheimers Res Ther. 2014 Jul 21;6(4):46
pubmed: 25484925
Neurology. 2021 May 18;96(20):e2513-e2524
pubmed: 33837116
Biochim Biophys Acta. 2007 Jun;1772(6):681-91
pubmed: 17254754
Acta Neuropathol. 1988;75(4):345-53
pubmed: 3364159
Acta Neuropathol. 2021 Jul;142(1):87-115
pubmed: 33978813
Nature. 1997 Aug 28;388(6645):839-40
pubmed: 9278044
Proc Natl Acad Sci U S A. 2022 Feb 8;119(6):
pubmed: 35115402
Neurobiol Aging. 2003 Mar-Apr;24(2):197-211
pubmed: 12498954
Transl Neurodegener. 2022 Jul 28;11(1):37
pubmed: 35902902
Ann Clin Transl Neurol. 2020 Jun;7(6):932-944
pubmed: 32538552
Mov Disord. 2018 Oct;33(10):1551-1554
pubmed: 30288780
Mov Disord. 2019 Apr;34(4):536-544
pubmed: 30840785
Neurology. 2007 Aug 21;69(8):747-54
pubmed: 17709706
Parkinsonism Relat Disord. 2014 Nov;20(11):1157-60
pubmed: 25258327
Nat Protoc. 2016 Nov;11(11):2233-2242
pubmed: 27735933
Mov Disord. 2003 Sep;18 Suppl 6:S72-9
pubmed: 14502659
Ann Clin Transl Neurol. 2019 Oct;6(10):2120-2126
pubmed: 31599499
Neurology. 2021 Aug 31;97(9):e930-e940
pubmed: 34210822
Nat Med. 2008 May;14(5):501-3
pubmed: 18391963
J Alzheimers Dis. 2016;52(1):205-11
pubmed: 27060948
Mov Disord. 2015 Sep;30(10):1417-21
pubmed: 26208108
Mov Disord. 2009;24 Suppl 2:S742-7
pubmed: 19877240
Nat Cell Biol. 2009 Mar;11(3):328-36
pubmed: 19198598
Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):E5308-17
pubmed: 26324905
J Neurosci Methods. 2015 Nov 30;255:38-51
pubmed: 26247888
Parkinsonism Relat Disord. 2018 Apr;49:9-16
pubmed: 29310988
Brain. 2011 May;134(Pt 5):1493-1505
pubmed: 21596773
Acta Neuropathol. 2018 Jun;135(6):855-875
pubmed: 29502200
Neurology. 2005 Dec 27;65(12):1863-72
pubmed: 16237129
Mov Disord. 2021 Sep;36(9):2173-2177
pubmed: 34002890
Mov Disord. 2014 Sep;29(10):1244-51
pubmed: 24996051
Lancet Neurol. 2021 May;20(5):385-397
pubmed: 33894193
Ann Clin Transl Neurol. 2016 Aug 28;3(10):812-818
pubmed: 27752516
J Neurochem. 2006 Apr;97(1):265-79
pubmed: 16524375
Ann Neurol. 2012 Oct;72(4):517-24
pubmed: 23109146
Parkinsonism Relat Disord. 2013 Jan;19(1):27-31; discussion 27
pubmed: 22858179
Mov Disord. 2020 Feb;35(2):268-278
pubmed: 31758740
Acta Neuropathol. 2020 Jul;140(1):49-62
pubmed: 32342188
Mov Disord. 2007 Sep 15;22(12):1689-707; quiz 1837
pubmed: 17542011
Brain. 2014 Sep;137(Pt 9):2493-508
pubmed: 25062696
Transl Neurodegener. 2020 Jan 17;9:5
pubmed: 31988747
Nature. 2020 Feb;578(7794):273-277
pubmed: 32025029
JAMA Neurol. 2016 Nov 01;73(11):1334-1341
pubmed: 27654968
Nature. 2016 Oct 26;538(7626):S13-S16
pubmed: 27783578
Front Neuroanat. 2014 Dec 18;8:159
pubmed: 25565982
Nat Neurosci. 2020 Jan;23(1):21-31
pubmed: 31792467
Neuron. 2016 Feb 3;89(3):433-48
pubmed: 26844828
F1000Res. 2017 Aug 30;6:1604
pubmed: 28928962
Mov Disord. 2022 May;37(5):1059-1063
pubmed: 35278004
Brain Pathol. 2008 Apr;18(2):220-4
pubmed: 18241240
Methods Mol Biol. 2019;1873:19-37
pubmed: 30341601
Acta Neuropathol Commun. 2018 Feb 9;6(1):7
pubmed: 29422107
Acta Neuropathol. 2020 Jun;139(6):977-1000
pubmed: 32356200
Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19555-60
pubmed: 24218576
BMC Med. 2018 Mar 6;16(1):34
pubmed: 29510692
Acta Neuropathol. 2009 Jun;117(6):635-52
pubmed: 19330340
J Biol Chem. 2001 Jul 20;276(29):27441-8
pubmed: 11316809
Nat Methods. 2008 Mar;5(3):211-2
pubmed: 18309304
Neurobiol Dis. 2021 Dec;161:105557
pubmed: 34763110

Auteurs

Matthias Schmitz (M)

Department of Neurology, National Reference Center for TSE, The German Center for Neurodegenerative Diseases (DZNE), Georg-August-University, University Medicine Gottingen, Goettingen, Germany. matthias.schmitz@med.uni-goettingen.de.

Niccolò Candelise (N)

National Center for Drug Research and Evaluation, Institute Superiore di Sanità, Rome, Italy.

Sezgi Canaslan (S)

Department of Neurology, National Reference Center for TSE, The German Center for Neurodegenerative Diseases (DZNE), Georg-August-University, University Medicine Gottingen, Goettingen, Germany.

Hermann C Altmeppen (HC)

Institute of Neuropathology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.

Jakob Matschke (J)

Institute of Neuropathology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.

Markus Glatzel (M)

Institute of Neuropathology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.

Neelam Younas (N)

Department of Neurology, National Reference Center for TSE, The German Center for Neurodegenerative Diseases (DZNE), Georg-August-University, University Medicine Gottingen, Goettingen, Germany.

Saima Zafar (S)

Department of Neurology, National Reference Center for TSE, The German Center for Neurodegenerative Diseases (DZNE), Georg-August-University, University Medicine Gottingen, Goettingen, Germany.

Peter Hermann (P)

Department of Neurology, National Reference Center for TSE, The German Center for Neurodegenerative Diseases (DZNE), Georg-August-University, University Medicine Gottingen, Goettingen, Germany.

Inga Zerr (I)

Department of Neurology, National Reference Center for TSE, The German Center for Neurodegenerative Diseases (DZNE), Georg-August-University, University Medicine Gottingen, Goettingen, Germany.

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questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles de l'homéostasie des protéines › Synucléinopathies › α-Synuclein conformers reveal link to clinical...
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questionsmedicales.fr › Cellules › Structures cellulaires › Corps d'inclusion › Corps de Lewy › α-Synuclein conformers reveal link to clinical...
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