Arbovirus circulation, epidemiology and spatiotemporal distribution in Uganda.
Journal
IJID regions
ISSN: 2772-7076
Titre abrégé: IJID Reg
Pays: England
ID NLM: 9918418183106676
Informations de publication
Date de publication:
Mar 2023
Mar 2023
Historique:
received:
01
12
2022
revised:
25
01
2023
accepted:
26
01
2023
entrez:
14
3
2023
pubmed:
15
3
2023
medline:
15
3
2023
Statut:
epublish
Résumé
Arboviruses are endemic in Uganda; however, little is known about their epidemiology, seasonality and spatiotemporal distribution. Our study sought to provide information on arbovirus outbreaks from acute clinical presentations. Immunoglobulin M (IgM) and confirmatory Plaque Reduction Neutralisation Test (PRNT) results for arbovirus diagnosis of samples collected from patients attending sentinel sites from 2016-19 were analysed retrospectively. Demographic data were analysed with SaTScan and SPSS software to determine the epidemiology and spatiotemporal distribution of arboviruses. Arbovirus activity peaked consistently during March-May rainy seasons. Overall, arbovirus seroprevalence was 9.5%. Of 137 IgM positives, 52.6% were confirmed by PRNT, of which 73.6% cases were observed in central Uganda with Yellow Fever Virus had the highest prevalence (27.8%). The 5-14 age group were four times more likely to be infected with an arbovirus p=0.003, 4.1 (95% CI 1.3-12.3). Significant arboviral activity was observed among outdoor workers(p=0.05) . Spatiotemporal analysis indicated arboviral activity in 23 of the 85 districts analysed.. Our study shows that arbovirus activity peaks during the March-May rainy season and highlights the need for YFV mass vaccination to reduce the clinical burden of arboviruses transmitted within the region.
Sections du résumé
Background
UNASSIGNED
Arboviruses are endemic in Uganda; however, little is known about their epidemiology, seasonality and spatiotemporal distribution. Our study sought to provide information on arbovirus outbreaks from acute clinical presentations.
Methods
UNASSIGNED
Immunoglobulin M (IgM) and confirmatory Plaque Reduction Neutralisation Test (PRNT) results for arbovirus diagnosis of samples collected from patients attending sentinel sites from 2016-19 were analysed retrospectively. Demographic data were analysed with SaTScan and SPSS software to determine the epidemiology and spatiotemporal distribution of arboviruses.
Results
UNASSIGNED
Arbovirus activity peaked consistently during March-May rainy seasons. Overall, arbovirus seroprevalence was 9.5%. Of 137 IgM positives, 52.6% were confirmed by PRNT, of which 73.6% cases were observed in central Uganda with Yellow Fever Virus had the highest prevalence (27.8%). The 5-14 age group were four times more likely to be infected with an arbovirus p=0.003, 4.1 (95% CI 1.3-12.3). Significant arboviral activity was observed among outdoor workers(p=0.05) . Spatiotemporal analysis indicated arboviral activity in 23 of the 85 districts analysed..
Interpretation
UNASSIGNED
Our study shows that arbovirus activity peaks during the March-May rainy season and highlights the need for YFV mass vaccination to reduce the clinical burden of arboviruses transmitted within the region.
Identifiants
pubmed: 36915800
doi: 10.1016/j.ijregi.2023.01.013
pii: S2772-7076(23)00013-9
pmc: PMC10006739
doi:
Types de publication
Journal Article
Langues
eng
Pagination
171-176Informations de copyright
© 2023 The Authors.
Déclaration de conflit d'intérêts
All authors declare no conflict of interest.
Références
Lancet Infect Dis. 2017 Mar;17(3):330-338
pubmed: 28017559
Lancet Neurol. 2020 Oct;19(10):826-839
pubmed: 32949543
Philos Trans A Math Phys Eng Sci. 2005 Jan 15;363(1826):49-54
pubmed: 15598620
Lancet Infect Dis. 2017 Mar;17(3):e101-e106
pubmed: 28011234
BMC Infect Dis. 2018 Nov 3;18(1):548
pubmed: 30390621
Vector Borne Zoonotic Dis. 2010 Apr;10(3):249-58
pubmed: 19589060
PLoS Negl Trop Dis. 2017 Sep 27;11(9):e0005959
pubmed: 28953892
J Clin Microbiol. 2000 May;38(5):1823-6
pubmed: 10790107
Int J Infect Dis. 2012 Jul;16(7):e536-42
pubmed: 22575876
PLoS Negl Trop Dis. 2019 Jan 14;13(1):e0007084
pubmed: 30640900
Bull World Health Organ. 1970;42(5):797-805
pubmed: 5311064
BMC Microbiol. 2020 Jun 26;20(1):181
pubmed: 32590939
Vector Borne Zoonotic Dis. 2018 Jul;18(7):364-370
pubmed: 29768102
Emerg Infect Dis. 2004 Sep;10(9):1578-84
pubmed: 15498159
J Clin Microbiol. 2017 Dec 26;56(1):
pubmed: 29093104
J Gen Virol. 2018 Sep;99(9):1248-1252
pubmed: 29975185
Microbes Infect. 2002 Nov;4(14):1459-68
pubmed: 12475636
MMWR Morb Mortal Wkly Rep. 2016 Jun 03;65(21):543-6
pubmed: 27254248
Trop Dis Travel Med Vaccines. 2019 Nov 29;5:21
pubmed: 31798935
Am J Public Health. 1998 Sep;88(9):1377-80
pubmed: 9736881
Viruses. 2019 Feb 12;11(2):
pubmed: 30759739
J Med Entomol. 2012 Nov;49(6):1289-306
pubmed: 23270157
Am J Trop Med Hyg. 2020 Dec;103(6):2429-2437
pubmed: 33124532
BMC Infect Dis. 2021 Mar 17;21(1):265
pubmed: 33731022
Science. 1967 Dec 8;158(3806):1283-6
pubmed: 6058003