Pangenome Analysis of a Salmonella Enteritidis Population Links a Major Outbreak to a Gifsy-1-Like Prophage Containing Anti-Inflammatory Gene

Salmonella Enteritidis accessory genome foodborne pathogen gogB pangenome prophage virulence factor whole-genome sequencing

Journal

Microbiology spectrum
ISSN: 2165-0497
Titre abrégé: Microbiol Spectr
Pays: United States
ID NLM: 101634614

Informations de publication

Date de publication:
14 Mar 2023
Historique:
entrez: 14 3 2023
pubmed: 15 3 2023
medline: 15 3 2023
Statut: aheadofprint

Résumé

A major outbreak of the globally significant Salmonella Enteritidis foodborne pathogen was identified within a large clinical data set by a program of routine WGS of clinical presentations of salmonellosis in New South Wales, Australia. Pangenome analysis helped to quantify and isolate prophage content within the accessory partition of the pangenome. A prophage similar to Gifsy-1 (henceforth GF-1L) was found to occur in all isolates of the outbreak core SNP cluster, and in three other isolates. Further analysis revealed that the GF-1L prophage carried the

Identifiants

DOI: 10.1128/spectrum.02791-22 PMID: 36916949 PMC: PMC10100743
pubmed: 36916949
doi: 10.1128/spectrum.02791-22
pmc: PMC10100743
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0279122

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Auteurs

Adam J Svahn (AJ)

Centre for Complex Systems, Faculty of Engineering, The University of Sydney, Sydney, NSW, Australia.
Sydney Infectious Diseases Institute, The University of Sydney, Westmead, NSW, Australia.
ORCID: 0000-0003-2320-0040

Carl J E Suster (CJE)

Sydney Infectious Diseases Institute, The University of Sydney, Westmead, NSW, Australia.
Centre for Infectious Diseases and Microbiology-Public Health, Westmead Hospital, Westmead, New South Wales, Australia.

Sheryl L Chang (SL)

Centre for Complex Systems, Faculty of Engineering, The University of Sydney, Sydney, NSW, Australia.

Rebecca J Rockett (RJ)

Sydney Infectious Diseases Institute, The University of Sydney, Westmead, NSW, Australia.
Centre for Infectious Diseases and Microbiology-Public Health, Westmead Hospital, Westmead, New South Wales, Australia.

Eby M Sim (EM)

Sydney Infectious Diseases Institute, The University of Sydney, Westmead, NSW, Australia.
Centre for Infectious Diseases and Microbiology-Public Health, Westmead Hospital, Westmead, New South Wales, Australia.
ORCID: 0000-0002-3716-7344

Oliver M Cliff (OM)

Centre for Complex Systems, Faculty of Engineering, The University of Sydney, Sydney, NSW, Australia.
School of Physics, Faculty of Science, The University of Sydney, Sydney, NSW, Australia.

Qinning Wang (Q)

Centre for Infectious Diseases and Microbiology-Public Health, Westmead Hospital, Westmead, New South Wales, Australia.
Institute of Clinical Pathology and Medical Research, NSW Health Pathology, Westmead, NSW, Australia.
ORCID: 0000-0002-2236-2219

Alicia Arnott (A)

Sydney Infectious Diseases Institute, The University of Sydney, Westmead, NSW, Australia.
Centre for Infectious Diseases and Microbiology-Public Health, Westmead Hospital, Westmead, New South Wales, Australia.
Institute of Clinical Pathology and Medical Research, NSW Health Pathology, Westmead, NSW, Australia.
ORCID: 0000-0003-2637-8936

Marc Ramsperger (M)

Institute of Clinical Pathology and Medical Research, NSW Health Pathology, Westmead, NSW, Australia.

Tania C Sorrell (TC)

Sydney Infectious Diseases Institute, The University of Sydney, Westmead, NSW, Australia.
Centre for Infectious Diseases and Microbiology-Public Health, Westmead Hospital, Westmead, New South Wales, Australia.

Vitali Sintchenko (V)

Sydney Infectious Diseases Institute, The University of Sydney, Westmead, NSW, Australia.
Centre for Infectious Diseases and Microbiology-Public Health, Westmead Hospital, Westmead, New South Wales, Australia.
Institute of Clinical Pathology and Medical Research, NSW Health Pathology, Westmead, NSW, Australia.
ORCID: 0000-0002-9261-3650

Mikhail Prokopenko (M)

Centre for Complex Systems, Faculty of Engineering, The University of Sydney, Sydney, NSW, Australia.
Sydney Infectious Diseases Institute, The University of Sydney, Westmead, NSW, Australia.

Classifications MeSH