Functional SARS-CoV-2 cross-reactive CD4


Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
21 03 2023
Historique:
entrez: 14 3 2023
pubmed: 15 3 2023
medline: 17 3 2023
Statut: ppublish

Résumé

Pre-existing SARS-CoV-2-reactive T cells have been identified in SARS-CoV-2-unexposed individuals, potentially modulating COVID-19 and vaccination outcomes. Here, we provide evidence that functional cross-reactive memory CD4

Identifiants

pubmed: 36917669
doi: 10.1073/pnas.2220320120
pmc: PMC10041119
doi:

Substances chimiques

Spike Glycoprotein, Coronavirus 0
Antibodies, Viral 0
spike protein, SARS-CoV-2 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2220320120

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Auteurs

Marion Humbert (M)

Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, 141 52 Huddinge, Sweden.
Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, 141 52 Huddinge, Sweden.

Anna Olofsson (A)

Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, 141 52 Huddinge, Sweden.

David Wullimann (D)

Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, 141 52 Huddinge, Sweden.

Julia Niessl (J)

Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, 141 52 Huddinge, Sweden.

Emma B Hodcroft (EB)

Institute of Social and Preventive Medicine, University of Bern, Bern 3012, Switzerland.
Swiss Institute of Bioinformatics, Lausanne 1015, Switzerland.

Curtis Cai (C)

Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, 141 52 Huddinge, Sweden.

Yu Gao (Y)

Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, 141 52 Huddinge, Sweden.

Ebba Sohlberg (E)

Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, 141 52 Huddinge, Sweden.

Robert Dyrdak (R)

Department of Clinical Microbiology, Karolinska University Hospital, 171 76 Stockholm, Sweden.
Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 171 77 Stockholm, Sweden.

Flora Mikaeloff (F)

Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, 141 52 Huddinge, Sweden.

Ujjwal Neogi (U)

Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, 141 52 Huddinge, Sweden.

Jan Albert (J)

Department of Clinical Microbiology, Karolinska University Hospital, 171 76 Stockholm, Sweden.
Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 171 77 Stockholm, Sweden.

Karl-Johan Malmberg (KJ)

Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, 141 52 Huddinge, Sweden.
Department of Cancer Immunology, Institute for Cancer Research, University of Oslo, 0379 Oslo, Norway.
Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital, 0379 Oslo, Norway.

Fridtjof Lund-Johansen (F)

Department of Immunology, Institute of Clinical Medicine, Oslo University Hospital, 0372 Oslo, Norway.
ImmunoLingo Convergence Center, Institute of Clinical Medicine, University of Oslo, 0372 Oslo, Norway.

Soo Aleman (S)

Unit for Infectious Diseases and Dermatology, I73, Karolinska University Hospital, Huddinge, 141 86 Stockholm, Sweden.
Infectious Diseases and Dermatology Unit, Department of Medicine, Huddinge, Karolinska Institutet, 141 86 Huddinge, Sweden.

Linda Björkhem-Bergman (L)

Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 141 83 Huddinge, Sweden.
Palliative Medicine, Stockholms Sjukhem, 112 19 Stockholm, Sweden.

Maria C Jenmalm (MC)

Division of Inflammation and Infection, Department of Biomedical and Clinical Sciences, Linköping University, 581 83 Linköping, Sweden.

Hans-Gustaf Ljunggren (HG)

Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, 141 52 Huddinge, Sweden.

Marcus Buggert (M)

Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, 141 52 Huddinge, Sweden.

Annika C Karlsson (AC)

Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, 141 52 Huddinge, Sweden.

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Classifications MeSH