Reactive oxygen species and ovarian diseases: Antioxidant strategies.
Antioxidant drugs
Hormones
Mesenchymal stem cells
Ovarian diseases
Oxidative stress
Reactive oxygen species
Journal
Redox biology
ISSN: 2213-2317
Titre abrégé: Redox Biol
Pays: Netherlands
ID NLM: 101605639
Informations de publication
Date de publication:
06 2023
06 2023
Historique:
received:
15
02
2023
revised:
02
03
2023
accepted:
05
03
2023
medline:
12
5
2023
pubmed:
15
3
2023
entrez:
14
3
2023
Statut:
ppublish
Résumé
Reactive oxygen species (ROS) are mainly produced in mitochondria and are involved in various physiological activities of the ovary through signaling and are critical for regulating the ovarian cycle. Notably, the imbalance between ROS generation and the antioxidant defense system contributes to the development of ovarian diseases. These contradictory effects have critical implications for potential antioxidant strategies that aim to scavenge excessive ROS. However, much remains to be learned about how ROS causes various ovarian diseases to the application of antioxidant therapy for ovarian diseases. Here, we review the mechanisms of ROS generation and maintenance of homeostasis in the ovary and its associated physiological effects. Additionally, we have highlighted the pathological mechanisms of ROS in ovarian diseases and potential antioxidant strategies for treatment.
Identifiants
pubmed: 36917900
pii: S2213-2317(23)00060-5
doi: 10.1016/j.redox.2023.102659
pmc: PMC10023995
pii:
doi:
Substances chimiques
Reactive Oxygen Species
0
Antioxidants
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
102659Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.