Lung-to-heart ratio analysis using virtual planar images obtained from myocardial perfusion SPECT data: A phantom and clinical studies.
Myocardial ischemia and infarction
SPECT
image analysis
image reconstruction
Journal
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
ISSN: 1532-6551
Titre abrégé: J Nucl Cardiol
Pays: United States
ID NLM: 9423534
Informations de publication
Date de publication:
10 2023
10 2023
Historique:
received:
26
02
2022
accepted:
04
02
2023
medline:
23
10
2023
pubmed:
16
3
2023
entrez:
15
3
2023
Statut:
ppublish
Résumé
The lung-to-heart ratio (L/H ratio) in myocardial perfusion scintigraphy (MPS) is a useful marker that complements the sensitivity of ischemia detection. However, it requires planar imaging acquired following a separate protocol in addition to single-photon emission computed tomography (SPECT). We developed a novel method for constructing virtual planar image (VPI) from SPECT data. Myocardial phantoms using Tl-201 were built with different amounts of radioactivity in the lungs. SPECT data and conventional planar images of these phantoms were collected with an Anger-type gamma camera. VPIs were constructed by adding all coronal images reconstructed from SPECT data. The clinical utility of VPIs obtained from 52 patients who underwent MPS with Tc-99m sestamibi was evaluated. The radioactivity linearity of VPIs was satisfactory, with a correlation coefficient of r ≥ .99 between the measured amounts of radioactivity and image counts. The L/H ratios obtained from VPI analysis were strongly correlated with those of conventional planar images with a correlation coefficient of r ≥ .99 in the phantom study and r = .929 in clinical application. The accuracy of VPI-based L/H ratio analysis was comparable to that of conventional planar image-based analysis. VPIs could be used as an alternative method of obtaining planar images in clinical settings.
Sections du résumé
BACKGROUNDS
The lung-to-heart ratio (L/H ratio) in myocardial perfusion scintigraphy (MPS) is a useful marker that complements the sensitivity of ischemia detection. However, it requires planar imaging acquired following a separate protocol in addition to single-photon emission computed tomography (SPECT). We developed a novel method for constructing virtual planar image (VPI) from SPECT data.
METHODS
Myocardial phantoms using Tl-201 were built with different amounts of radioactivity in the lungs. SPECT data and conventional planar images of these phantoms were collected with an Anger-type gamma camera. VPIs were constructed by adding all coronal images reconstructed from SPECT data. The clinical utility of VPIs obtained from 52 patients who underwent MPS with Tc-99m sestamibi was evaluated.
RESULTS
The radioactivity linearity of VPIs was satisfactory, with a correlation coefficient of r ≥ .99 between the measured amounts of radioactivity and image counts. The L/H ratios obtained from VPI analysis were strongly correlated with those of conventional planar images with a correlation coefficient of r ≥ .99 in the phantom study and r = .929 in clinical application.
CONCLUSION
The accuracy of VPI-based L/H ratio analysis was comparable to that of conventional planar image-based analysis. VPIs could be used as an alternative method of obtaining planar images in clinical settings.
Identifiants
pubmed: 36918459
doi: 10.1007/s12350-023-03233-3
pii: 10.1007/s12350-023-03233-3
doi:
Substances chimiques
Thallium-201
H91Z8HBK1B
Thallium Radioisotopes
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1959-1967Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2023. The Author(s) under exclusive licence to American Society of Nuclear Cardiology.
Références
Galassi AR, Azzarelli S, Lupo L, Mammana C, Foti R, Tamburino C. Accuracy of exercise testing in the assessment of the severity of myocardial ischemia as determined by means of technetium-99m tetrofosmin SPECT scintigraphy. J Nucl Cardiol 2000;7:575‐83.
doi: 10.1067/mnc.2000.108731
pubmed: 11144472
Sharir T, Germano G, Kang X, Lewin HC, Miranda R, Cohen I, et al. Prediction of myocardial infarction versus cardiac death by gated myocardial perfusion SPECT: Risk stratification by the amount of stress-induced ischemia and the poststress ejection fraction. J Nucl Med 2001;42:831‐7.
pubmed: 11390544
Shaw LJ, Hendel RC, Heller GV, Borges-Neto S, Cerqueira M, Berman DS. Prognostic estimation of coronary artery disease risk with resting perfusion abnormalities and stress ischemia on myocardial perfusion SPECT. J Nucl Cardiol 2008;15:762‐73.
doi: 10.1007/BF03007357
pubmed: 18984451
Gimelli A, Liga R, Duce V, Kusch A, Clemente A, Marzullo P. Accuracy of myocardial perfusion imaging in detecting multivessel coronary artery disease: A cardiac CZT study. J Nucl Cardiol 2017;24:687‐95.
doi: 10.1007/s12350-015-0360-8
pubmed: 26846367
Travin MI, Katz MS, Moulton AW, Miele NJ, Sharaf BL, Johnson LL. Accuracy of dipyridamole SPECT imaging in identifying individual coronary stenoses and multivessel disease in women versus men. J Nucl Cardiol 2000;7:213‐20.
doi: 10.1016/S1071-3581(00)70009-2
pubmed: 10888391
Elhendy A, Sozzi FB, van Domburg RT, Bax JJ, Geleijnse ML, Valkema R, et al. Accuracy of exercise stress technetium 99m sestamibi SPECT imaging in the evaluation of the extent and location of coronary artery disease in patients with an earlier myocardial infarction. J Nucl Cardiol 2000;7:432‐8.
doi: 10.1067/mnc.2000.107426
pubmed: 11083191
Nishimura S, Mahmarian JJ, Verani MS. Significance of increased lung thallium uptake during adenosine thallium-201 scintigraphy. J Nucl Med 1992;33:1600‐7.
pubmed: 1517832
Villanueva FS, Kaul S, Smith WH, Watson DD, Varma SK, Beller GA. Prevalence and correlates of increased lung/heart ratio of thallium-201 during dipyridamole stress imaging for suspected coronary artery disease. Am J Cardiol 1990;66:1324‐8.
doi: 10.1016/0002-9149(90)91162-Y
pubmed: 2244562
Hansen CL, Cen P, Sanchez B, Robinson R. Comparison of pulmonary uptake with transient cavity dilation after dipyridamole Tl-201 perfusion imaging. J Nucl Cardiol 2002;9:47‐51.
doi: 10.1067/mnc.2002.118695
pubmed: 11845129
Mahmood S, Buscombe JR, Ell PJ. The use of thallium-201 lung/heart ratios. Eur J Nucl Med 1992;19:807‐14.
doi: 10.1007/BF00182824
pubmed: 1396877
Castellani M, Chiti A, Giovanella LC, Bestetti A, Lomuscio A, Tarolo GL. Thallium-201 lung uptake: Comparison of an automatic and a manual method of ROI drawing. J Nucl Biol Med 1993;37:213‐7.
pubmed: 8172962
Hitzel A, Manrique A, Cribier A, Vera P. Diagnostic value of Tl-201 lung uptake is dependent on measurement method. J Nucl Cardiol 2001;8:332‐8.
doi: 10.1067/mnc.2001.113515
pubmed: 11391303
Campeau RJ, Kronemer KA, Sutherland CM. Concordant uptake of Tc-99m sestamibi and Tl-201 in unsuspected breast tumor. Clin Nucl Med 1992;17:936‐7.
doi: 10.1097/00003072-199212000-00006
pubmed: 1334449
Malhotra G, Upadhye TS, Nabar A, Asopa RV, Nayak UN, Rajan MG. Can carbonated lime drink intake prior to myocardial perfusion imaging with Tc-99m MIBI reduce the extracardiac activity that degrades the image quality and leads to fallacies in interpretation? Clin Nucl Med 2010;35:160‐4.
doi: 10.1097/RLU.0b013e3181cc63a1
pubmed: 20173445
Go RT, MacIntyre WJ, Houser TS, Pantoja M, O’Donnell JK, Feiglin DH, et al. Clinical evaluation of 360 degrees and 180 degrees data sampling techniques for transaxial SPECT thallium-201 myocardial perfusion imaging. J Nucl Med 1985;26:695‐706.
pubmed: 3874270
Liu YH, Lam PT, Sinusas AJ, Wackers FJ. Differential effect of 180 degrees and 360 degrees acquisition orbits on the accuracy of SPECT imaging: Quantitative evaluation in phantoms. J Nucl Med 2002;43:1115‐24.
pubmed: 12163639
Maublant JC, Peycelon P, Kwiatkowski F, Lusson JR, Standke RH, Veyre A. Comparison between 180 degrees and 360 degrees data collection in technetium-99m MIBI SPECT of the myocardium. J Nucl Med 1989;30:295‐300.
pubmed: 2786937
Dorbala S, Ananthasubramaniam K, Armstrong IS, Chareonthaitawee P, DePuey EG, Einstein AJ, et al. Single photon emission computed tomography (SPECT) myocardial perfusion imaging guidelines: Instrumentation, acquisition, processing, and interpretation. J Nucl Cardiol 2018;25:1784‐846.
doi: 10.1007/s12350-018-1283-y
pubmed: 29802599
Hendel RC, Berman DS, Cullom SJ, Follansbee W, Heller GV, Kiat H, et al. Multicenter clinical trial to evaluate the efficacy of correction for photon attenuation and scatter in SPECT myocardial perfusion imaging. Circulation 1999;99:2742‐9.
doi: 10.1161/01.CIR.99.21.2742
pubmed: 10351967
Hansen CL. Digital image processing for clinicians, Part II: Filtering. J Nucl Cardiol 2002;9:429‐37.
doi: 10.1067/mnc.2002.122898
pubmed: 12161720
Hansen CL. Digital image processing for clinicians, Part III: SPECT reconstruction. J Nucl Cardiol 2002;9:542‐9.
doi: 10.1067/mnc.2002.122899
pubmed: 12360135
Leong LK, Kruger RL, O’Connor MK. A comparison of the uniformity requirements for SPECT image reconstruction using FBP and OSEM techniques. J Nucl Med Technol 2001;29:79‐83.
pubmed: 11376099
Shibutani T, Nakajima K, Yoneyama H, Konishi T, Okuda K, Onoguchi M, et al. The utility of heart-to-mediastinum ratio using a planar image created from IQ-SPECT with Iodine-123 meta-iodobenzylguanidine. J Nucl Cardiol 2021;28:2569‐77.
doi: 10.1007/s12350-020-02081-9
pubmed: 32103408