Effect of Moderate Intensity Continuous Training and Slow Type Interval Training to Gene Expression of TGF-β in Type 2 Diabetes Mellitus Model Wistar Rats.
TGF- β
continuous training
interval training
rats
type 2 diabetes mellitus
Journal
Medical archives (Sarajevo, Bosnia and Herzegovina)
ISSN: 1986-5961
Titre abrégé: Med Arch
Pays: Bosnia and Herzegovina
ID NLM: 101635337
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
received:
06
12
2022
accepted:
10
02
2023
entrez:
15
3
2023
pubmed:
16
3
2023
medline:
17
3
2023
Statut:
ppublish
Résumé
Physical exercise is a process of increasing contraction of skeletal muscles involving several organ systems to increase energy formation and it is one of the pillars for the management of type 2 diabetes mellitus (TDM2). T2DM affects the expression of the TGF-β gene. This study aims to determine the effect of moderate intensity continuous training and slow interval training in expression of TGF-β gene in wistar rats T2DM model. A moderate intensity continuous training physical activity given to the diabetic rat group in the form of running on a treadmill with a running speed of 20 m/min for 30 minutes while the slow type interval training physical activity given to the diabetic rat group was in the form of running on a treadmill with a running speed of 20 m/minute for 10 repetition sessions, with a duration of 2 minutes per session with interspersed active breaks for 1 minute. TGF-β gene expression was measured using real-time methods. The results in the continuous group, TGF-β significant decreased p < 0.05. In the interval group, TGF- β insignificant decreased p > 0.05. Moderate intensity continuous training was insignificantly better at decreasing the expression of the TGF-β genes. This research concluded that there is an effect of moderate intensity continuous training and slow interval training on the expression of TGF-β genes in wistar rats T2DM.
Sections du résumé
Background
UNASSIGNED
Physical exercise is a process of increasing contraction of skeletal muscles involving several organ systems to increase energy formation and it is one of the pillars for the management of type 2 diabetes mellitus (TDM2). T2DM affects the expression of the TGF-β gene.
Objective
UNASSIGNED
This study aims to determine the effect of moderate intensity continuous training and slow interval training in expression of TGF-β gene in wistar rats T2DM model.
Methods
UNASSIGNED
A moderate intensity continuous training physical activity given to the diabetic rat group in the form of running on a treadmill with a running speed of 20 m/min for 30 minutes while the slow type interval training physical activity given to the diabetic rat group was in the form of running on a treadmill with a running speed of 20 m/minute for 10 repetition sessions, with a duration of 2 minutes per session with interspersed active breaks for 1 minute. TGF-β gene expression was measured using real-time methods.
Results
UNASSIGNED
The results in the continuous group, TGF-β significant decreased p < 0.05. In the interval group, TGF- β insignificant decreased p > 0.05. Moderate intensity continuous training was insignificantly better at decreasing the expression of the TGF-β genes.
Conclusion
UNASSIGNED
This research concluded that there is an effect of moderate intensity continuous training and slow interval training on the expression of TGF-β genes in wistar rats T2DM.
Identifiants
pubmed: 36919130
doi: 10.5455/medarh.2023.77.4-7
pmc: PMC10008258
doi:
Substances chimiques
Transforming Growth Factor beta
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4-7Informations de copyright
© 2023 Muhammad Syahputra, Dharma Lindarto, Oke Rina Ramayani, Yetty Machrina, Ambrosius Purba, Imam Budi Putra, Iqbal Pahlevi Adeputra Nasution, Juliandi Harahap.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
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