Immune Response Modulation by Pseudomonas aeruginosa Persister Cells.
Pseudomonas aeruginosa
bacterial persister cells
chronic infections
complement
immune evasion
Journal
mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231
Informations de publication
Date de publication:
25 04 2023
25 04 2023
Historique:
medline:
27
4
2023
pubmed:
16
3
2023
entrez:
15
3
2023
Statut:
ppublish
Résumé
Bacterial persister cells-a metabolically dormant subpopulation tolerant to antimicrobials-contribute to chronic infections and are thought to evade host immunity. In this work, we studied the ability of Pseudomonas aeruginosa persister cells to withstand host innate immunity. We found that persister cells resist MAC-mediated killing by the complement system despite being bound by complement protein C3b at levels similar to regular vegetative cells, in part due to reduced bound C5b, and are engulfed at a lower rate (10- to 100-fold), even following opsonization. Once engulfed, persister cells resist killing and, contrary to regular vegetative cells which induce a M1 favored (CD80
Identifiants
pubmed: 36920189
doi: 10.1128/mbio.00056-23
pmc: PMC10128020
doi:
Substances chimiques
Anti-Bacterial Agents
0
Interleukin-10
130068-27-8
Interleukin-6
0
Tumor Necrosis Factor-alpha
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0005623Subventions
Organisme : NIH HHS
ID : 2 R25GM056637-14
Pays : United States
Commentaires et corrections
Type : UpdateOf
Références
Front Microbiol. 2019 Feb 21;10:100
pubmed: 30846971
Front Oncol. 2020 Jan 24;9:1512
pubmed: 32039007
Mol Microbiol. 2003 Nov;50(4):1199-213
pubmed: 14622409
Mol Nutr Food Res. 2012 May;56(5):822-33
pubmed: 22648628
J Med Microbiol. 1987 Feb;23(1):83-8
pubmed: 3546699
Antimicrob Agents Chemother. 2013 Mar;57(3):1468-73
pubmed: 23295927
Appl Environ Microbiol. 2014 Nov;80(22):6976-91
pubmed: 25192989
Front Immunol. 2014 Nov 28;5:614
pubmed: 25506346
Science. 1999 May 21;284(5418):1318-22
pubmed: 10334980
Am J Respir Cell Mol Biol. 2003 Oct;29(4):432-8
pubmed: 14500254
PLoS Pathog. 2017 Nov 30;13(11):e1006734
pubmed: 29190284
Microbes Infect. 2005 Mar;7(3):476-84
pubmed: 15792635
Cell Microbiol. 2012 Jan;14(1):95-106
pubmed: 21951860
Infect Immun. 2015 Aug;83(8):3006-14
pubmed: 25964476
Science. 2004 Sep 10;305(5690):1622-5
pubmed: 15308767
J Mol Med (Berl). 2010 Feb;88(2):115-20
pubmed: 20062962
Clin Microbiol Rev. 2009 Apr;22(2):240-73, Table of Contents
pubmed: 19366914
Elife. 2019 Jun 10;8:
pubmed: 31180327
FEBS Lett. 2010 Feb 5;584(3):555-61
pubmed: 19945458
J Immunol. 2007 Apr 1;178(7):4489-97
pubmed: 17372007
Science. 2018 Dec 7;362(6419):1156-1160
pubmed: 30523110
Trends Microbiol. 2015 Jan;23(1):7-13
pubmed: 25449050
Environ Microbiol. 2021 Sep;23(9):5605-5620
pubmed: 34390618
Science. 2011 Nov 18;334(6058):982-6
pubmed: 22096200
Microbes Infect. 2012 Sep;14(11):959-67
pubmed: 22546526
J Bacteriol. 2010 Apr;192(7):1946-55
pubmed: 20097861
J Appl Microbiol. 2003;95(6):1261-7
pubmed: 14633000
J Bacteriol. 2010 Dec;192(23):6191-9
pubmed: 20935098
Environ Microbiol. 2018 Jun;20(6):2038-2048
pubmed: 29457686
PLoS Biol. 2010 Feb 23;8(2):e1000317
pubmed: 20186264
PLoS Pathog. 2018 Feb 2;14(2):e1006842
pubmed: 29394295
Infect Immun. 1989 Jun;57(6):1707-13
pubmed: 2498205
Infect Immun. 2015 Oct 26;84(1):241-53
pubmed: 26502911
Sci Adv. 2019 Jun 19;5(6):eaav9462
pubmed: 31223653
Annu Rev Physiol. 2017 Feb 10;79:541-566
pubmed: 27813830
Cell Rep. 2022 Mar 1;38(9):110427
pubmed: 35235801
Virulence. 2014 Aug 15;5(6):673-9
pubmed: 25098744
Immunology. 2006 Apr;117(4):482-93
pubmed: 16556262
Sci Rep. 2016 Aug 10;6:31342
pubmed: 27506163
J Med Microbiol. 1994 Jan;40(1):23-30
pubmed: 8289210
Science. 2014 Jan 10;343(6167):204-8
pubmed: 24408438
J Immunol. 2007 Sep 1;179(5):2979-88
pubmed: 17709513
J Bacteriol. 2013 Feb;195(4):647-57
pubmed: 23204462
Infect Immun. 2010 Apr;78(4):1447-56
pubmed: 20100855
Infect Immun. 1999 Feb;67(2):664-9
pubmed: 9916074
J Leukoc Biol. 2019 Aug;106(2):345-358
pubmed: 30576000
Cell Host Microbe. 2015 Jan 14;17(1):32-46
pubmed: 25543231
PLoS One. 2015 Sep 14;10(9):e0137630
pubmed: 26368530
Antimicrob Agents Chemother. 2002 Jul;46(7):2095-103
pubmed: 12069960
PLoS Pathog. 2019 Jun 20;15(6):e1007812
pubmed: 31220187
Antimicrob Agents Chemother. 2005 Aug;49(8):3222-7
pubmed: 16048929
J Bacteriol. 2004 Dec;186(24):8172-80
pubmed: 15576765
Nucleic Acids Res. 2014 Sep;42(15):10134-47
pubmed: 25056321
J Bacteriol. 2011 Jul;193(14):3598-605
pubmed: 21602347
PLoS Pathog. 2020 Dec 16;16(12):e1008893
pubmed: 33326490
Nat Immunol. 2008 Apr;9(4):353-9
pubmed: 18349815
Mol Microbiol. 2019 May;111(5):1211-1228
pubmed: 30710463
Infect Immun. 1986 Dec;54(3):689-94
pubmed: 3096887
Environ Microbiol. 2018 Jun;20(6):2085-2098
pubmed: 29528544
Front Cell Infect Microbiol. 2016 Oct 14;6:125
pubmed: 27790409
BMC Microbiol. 2006 Jun 12;6:53
pubmed: 16768798
Curr Top Microbiol Immunol. 2008;322:107-31
pubmed: 18453274
Mol Microbiol. 2010 Jan;75(2):333-48
pubmed: 19943910
Nat Commun. 2020 May 4;11(1):2200
pubmed: 32366839
PLoS Genet. 2009 Dec;5(12):e1000760
pubmed: 20011100
Clin Infect Dis. 2008 Dec 15;47(12):1526-33
pubmed: 18990062