Comparison of Toxicities among Different Bumped Kinase Inhibitor Analogs for Treatment of Cryptosporidiosis.

Animals Cattle Mice Rats Cryptosporidiosis / drug therapy Antiprotozoal Agents / pharmacology Antineoplastic Agents / pharmacology Protein Kinase Inhibitors / pharmacology Oocysts Cryptosporidium parvum
BKI-1708 BKI-1770 BKI-1841 Cryptosporidium bumped kinase inhibitors calcium-dependent protein kinases cryptosporidiosis epiphyseal growth plate

Journal

Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061

Informations de publication

Date de publication:
18 04 2023
Historique:
medline: 20 4 2023
pubmed: 16 3 2023
entrez: 15 3 2023
Statut: ppublish

Résumé

Recent advances on the development of bumped kinase inhibitors for treatment of cryptosporidiosis have focused on the 5-aminopyrazole-4-carboxamide scaffold, due to analogs that have less hERG inhibition, superior efficacy, and strong

Identifiants

DOI: 10.1128/aac.01425-22 PMID: 36920244 PMC: PMC10112232
pubmed: 36920244
doi: 10.1128/aac.01425-22
pmc: PMC10112232
doi:

Substances chimiques

Antiprotozoal Agents 0
Antineoplastic Agents 0
Protein Kinase Inhibitors 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0142522

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI155412
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD102487
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD080670
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI111341
Pays : United States

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Auteurs

Matthew A Hulverson (MA)

Department of Medicine, Division of Allergy and Infectious Disease, Center for Emerging and Reemerging Infectious Disease (CERID), University of Washington, Seattle, Washington, USA.
ORCID: 0000-0002-3413-4969

Ryan Choi (R)

Department of Medicine, Division of Allergy and Infectious Disease, Center for Emerging and Reemerging Infectious Disease (CERID), University of Washington, Seattle, Washington, USA.

Deborah A Schaefer (DA)

School of Animal and Comparative Biomedical Sciences, College of Agriculture and Life Sciences, University of Arizona, Tucson, Arizona, USA.

Dana P Betzer (DP)

School of Animal and Comparative Biomedical Sciences, College of Agriculture and Life Sciences, University of Arizona, Tucson, Arizona, USA.

Molly C McCloskey (MC)

Department of Medicine, Division of Allergy and Infectious Disease, Center for Emerging and Reemerging Infectious Disease (CERID), University of Washington, Seattle, Washington, USA.

Grant R Whitman (GR)

Department of Medicine, Division of Allergy and Infectious Disease, Center for Emerging and Reemerging Infectious Disease (CERID), University of Washington, Seattle, Washington, USA.
ORCID: 0000-0001-5634-3764

Wenlin Huang (W)

Department of Biochemistry, University of Washington, Seattle, Washington, USA.

Sangun Lee (S)

Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine at Tufts University, North Grafton, Massachusetts, USA.
ORCID: 0000-0002-7983-9460

Andy Pranata (A)

Research School of Chemistry, Australian National University, Canberra, ACT, Australia.

Malcolm D McLeod (MD)

Research School of Chemistry, Australian National University, Canberra, ACT, Australia.

Kennan C Marsh (KC)

Research and Development, AbbVie, Inc., North Chicago, Illinois, USA.

Dale J Kempf (DJ)

Research and Development, AbbVie, Inc., North Chicago, Illinois, USA.
Former employee of AbbVie, Inc., North Chicago, Illinois, USA.

Bruce E LeRoy (BE)

Research and Development, AbbVie, Inc., North Chicago, Illinois, USA.

Mark T Zafiratos (MT)

Research and Development, AbbVie, Inc., North Chicago, Illinois, USA.

Aimee L Bielinski (AL)

Research and Development, AbbVie, Inc., North Chicago, Illinois, USA.

Robert C Hackman (RC)

Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Department of Pathology, University of Washington, Seattle, Washington, USA.
Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA.

Kayode K Ojo (KK)

Department of Medicine, Division of Allergy and Infectious Disease, Center for Emerging and Reemerging Infectious Disease (CERID), University of Washington, Seattle, Washington, USA.

Samuel L M Arnold (SLM)

Department of Medicine, Division of Allergy and Infectious Disease, Center for Emerging and Reemerging Infectious Disease (CERID), University of Washington, Seattle, Washington, USA.
ORCID: 0000-0001-8290-2347

Lynn K Barrett (LK)

Department of Medicine, Division of Allergy and Infectious Disease, Center for Emerging and Reemerging Infectious Disease (CERID), University of Washington, Seattle, Washington, USA.

Saul Tzipori (S)

Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine at Tufts University, North Grafton, Massachusetts, USA.

Michael W Riggs (MW)

School of Animal and Comparative Biomedical Sciences, College of Agriculture and Life Sciences, University of Arizona, Tucson, Arizona, USA.

Erkang Fan (E)

Department of Biochemistry, University of Washington, Seattle, Washington, USA.

Wesley C Van Voorhis (WC)

Department of Medicine, Division of Allergy and Infectious Disease, Center for Emerging and Reemerging Infectious Disease (CERID), University of Washington, Seattle, Washington, USA.
ORCID: 0000-0001-6141-2015

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Comparison of Toxicities among Different...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Ruminants › Bovins › Comparison of Toxicities among Different...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Comparison of Toxicities among Different...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Comparison of Toxicities among Different...
questionsmedicales.fr › Maladies de l'animal › Parasitoses animales › Protozooses animales › Cryptosporidiose › Comparison of Toxicities among Different...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiparasitaires › Antiprotozoaires › Comparison of Toxicities among Different...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Comparison of Toxicities among Different...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de protéines kinases › Comparison of Toxicities among Different...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Morphogenèse › Métamorphose biologique › Étapes du cycle de vie › Oocystes › Comparison of Toxicities among Different...
questionsmedicales.fr › Eucaryotes › Alveolata › Apicomplexa › Coccidia › Eimeriida › Cryptosporidiidae › Cryptosporidium › Cryptosporidium parvum › Comparison of Toxicities among Different...