Diet-induced loss of adipose hexokinase 2 correlates with hyperglycemia.
adipose tissue
astyanax mexicanus
cell biology
diabetes
glucose
human
lipid metabolism
mouse
obesity
selective insulin resistance
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
15 03 2023
15 03 2023
Historique:
received:
22
11
2022
accepted:
19
02
2023
entrez:
15
3
2023
pubmed:
16
3
2023
medline:
21
3
2023
Statut:
epublish
Résumé
Chronically high blood glucose (hyperglycemia) leads to diabetes and fatty liver disease. Obesity is a major risk factor for hyperglycemia, but the underlying mechanism is unknown. Here, we show that a high-fat diet (HFD) in mice causes early loss of expression of the glycolytic enzyme Hexokinase 2 (HK2) specifically in adipose tissue. Adipose-specific knockout of
Identifiants
pubmed: 36920797
doi: 10.7554/eLife.85103
pii: 85103
pmc: PMC10017106
doi:
pii:
Substances chimiques
Hexokinase
EC 2.7.1.1
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2023, Shimobayashi et al.
Déclaration de conflit d'intérêts
MS, AT, SS, IF, DW, AV, MP, ND, DR, TM, NH, RP, SF, NR, MH No competing interests declared, BW, AM is affiliated with St. Clara Research Ltd. The author has no other competing interests to declare
Références
Nat Commun. 2017 May 11;8:15267
pubmed: 28492237
Nature. 2012 Apr 19;484(7394):333-8
pubmed: 22466288
Diabetes. 2016 Jun;65(6):1577-89
pubmed: 27207531
Jpn J Physiol. 1973 Oct;23(5):497-508
pubmed: 4544381
Nature. 2019 Feb;566(7743):279-283
pubmed: 30700909
Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7569-74
pubmed: 12808134
Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9902-7
pubmed: 19497867
Am J Physiol. 1987 Dec;253(6 Pt 2):R942-4
pubmed: 3425770
Cell Rep. 2017 Oct 24;21(4):1021-1035
pubmed: 29069585
Elife. 2017 Jun 07;6:
pubmed: 28589878
Mol Metab. 2021 Mar;45:101161
pubmed: 33412345
Anal Biochem. 2012 Jun 1;425(1):88-90
pubmed: 22425542
J Hepatol. 2012 Jan;56(1):199-209
pubmed: 21835137
J Proteome Res. 2016 Aug 5;15(8):2537-47
pubmed: 27345528
Diabetes. 2005 Apr;54(4):935-43
pubmed: 15793230
Nature. 2018 Mar 29;555(7698):647-651
pubmed: 29562229
Nat Commun. 2016 Apr 21;7:11365
pubmed: 27098609
Nat Commun. 2018 Jan 31;9(1):446
pubmed: 29386513
Cell Rep. 2018 Oct 9;25(2):278-287.e4
pubmed: 30304668
Cell. 2015 Feb 12;160(4):745-758
pubmed: 25662011
Methods Mol Biol. 2019;1862:53-66
pubmed: 30315459
Proteomics. 2011 May;11(10):2019-26
pubmed: 21500348
Cell Metab. 2016 Jun 14;23(6):1154-1166
pubmed: 27238637
Proc Natl Acad Sci U S A. 2004 May 11;101(19):7281-6
pubmed: 15118080
Endocrinology. 2006 Mar;147(3):1140-7
pubmed: 16339209
Diabetes. 2010 Jun;59(6):1397-406
pubmed: 20332342
Nature. 2020 May;581(7809):434-443
pubmed: 32461654
J Clin Invest. 2018 Apr 2;128(4):1538-1550
pubmed: 29528335
Nature. 2022 Sep;609(7927):569-574
pubmed: 36045288
J Biol Chem. 1999 Aug 6;274(32):22517-23
pubmed: 10428828
Am J Physiol Regul Integr Comp Physiol. 2009 Mar;296(3):R501-11
pubmed: 19109367
Science. 1965 Dec 17;150(3703):1607-8
pubmed: 4286322
Nature. 2001 Feb 8;409(6821):729-33
pubmed: 11217863
J Biol Chem. 2002 Feb 8;277(6):3829-35
pubmed: 11724780
J Biol Chem. 2015 May 1;290(18):11337-48
pubmed: 25720492
PLoS One. 2019 Sep 11;14(9):e0221766
pubmed: 31509546
Cancer Cell. 2013 Aug 12;24(2):213-228
pubmed: 23911236
Diabetologia. 2010 Nov;53(11):2417-30
pubmed: 20623219
Cell Metab. 2008 Feb;7(2):95-6
pubmed: 18249166
J Clin Invest. 2002 May;109(9):1125-31
pubmed: 11994399
J Clin Endocrinol Metab. 1986 Sep;63(3):541-9
pubmed: 3734029
Genesis. 2010 Oct 1;48(10):618-25
pubmed: 20715175
J Clin Invest. 2016 Nov 1;126(11):4372-4386
pubmed: 27669460
Mol Metab. 2022 Nov;65:101580
pubmed: 36028121
Biochem Biophys Res Commun. 2010 May 7;395(3):395-400
pubmed: 20382127
Genes Dev. 2001 Jun 1;15(11):1406-18
pubmed: 11390360
Diabetes. 2001 May;50(5):1134-42
pubmed: 11334418
Am J Physiol Endocrinol Metab. 2009 Jan;296(1):E11-21
pubmed: 18840763
Am J Physiol Endocrinol Metab. 2014 Nov 15;307(10):E859-71
pubmed: 25205823
Cell Death Differ. 2008 Mar;15(3):521-9
pubmed: 18064042
Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5107-12
pubmed: 12684532
Front Genet. 2019 Jun 04;10:472
pubmed: 31275349
Biosci Rep. 2018 Feb 21;38(1):
pubmed: 29298880
J Biol Chem. 1993 Oct 25;268(30):22243-6
pubmed: 8226728
Nature. 1995 Sep 14;377(6545):151-5
pubmed: 7675081
RNA. 2003 Apr;9(4):493-501
pubmed: 12649500
Mol Metab. 2016 May 13;5(7):472-479
pubmed: 27408773
Nature. 2019 Dec;576(7785):51-60
pubmed: 31802013
Cell Metab. 2017 Feb 7;25(2):448-462
pubmed: 28065828