Programmed and environmental determinants driving neonatal mucosal immune development.
Journal
Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918
Informations de publication
Date de publication:
14 03 2023
14 03 2023
Historique:
received:
18
10
2022
accepted:
17
02
2023
pmc-release:
14
03
2024
entrez:
15
3
2023
pubmed:
16
3
2023
medline:
21
3
2023
Statut:
ppublish
Résumé
The mucosal immune system of neonates goes through successive, non-redundant phases that support the developmental needs of the infant and ultimately establish immune homeostasis. These phases are informed by environmental cues, including dietary and microbial stimuli, but also evolutionary developmental programming that functions independently of external stimuli. The immune response to exogenous stimuli is tightly regulated during early life; thresholds are set within this neonatal "window of opportunity" that govern how the immune system will respond to diet, the microbiota, and pathogenic microorganisms in the future. Thus, changes in early-life exposure, such as breastfeeding or environmental and microbial stimuli, influence immunological and metabolic homeostasis and the risk of developing diseases such as asthma/allergy and obesity.
Identifiants
pubmed: 36921575
pii: S1074-7613(23)00087-0
doi: 10.1016/j.immuni.2023.02.013
pmc: PMC10079302
mid: NIHMS1881373
pii:
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
485-499Subventions
Organisme : NCI NIH HHS
ID : R01 CA269902
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK120697
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI142051
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier Inc. All rights reserved.
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