Chemical, Molecular, and Single-nucleus Analysis Reveal Chondroitin Sulfate Proteoglycan Aberrancy in Fibrolamellar Carcinoma.
Journal
Cancer research communications
ISSN: 2767-9764
Titre abrégé: Cancer Res Commun
Pays: United States
ID NLM: 9918281580506676
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
received:
20
12
2021
revised:
21
03
2022
accepted:
22
06
2022
entrez:
16
3
2023
pubmed:
17
3
2023
medline:
17
3
2023
Statut:
epublish
Résumé
Fibrolamellar carcinoma (FLC) is an aggressive liver cancer with no effective therapeutic options. The extracellular environment of FLC tumors is poorly characterized and may contribute to cancer growth and/or metastasis. To bridge this knowledge gap, we assessed pathways relevant to proteoglycans, a major component of the extracellular matrix. We first analyzed gene expression data from FLC and nonmalignant liver tissue ( This study leverages a multi-disciplinary approach, including state-of-the-art chemical analyses and cutting-edge single-cell genomic technologies, to identify for the first time a marked chondroitin sulfate aberrancy in FLC that could open novel therapeutic avenues in the future.
Identifiants
pubmed: 36923282
doi: 10.1158/2767-9764.CRC-21-0177
pii: CRC-21-0177
pmc: PMC10010304
doi:
Substances chimiques
Chondroitin Sulfates
9007-28-7
Heparan Sulfate Proteoglycans
0
Versicans
126968-45-4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
663-678Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL144970
Pays : United States
Informations de copyright
© 2022 The Authors; Published by the American Association for Cancer Research.
Déclaration de conflit d'intérêts
J.K. Grenier reports a patent to method for combinatorial indexing pending. Z. Wang reports grants from University of North Carolina during the conduct of the study. J. Liu reports grants from University of North Carolina during the conduct of the study; grants and other from Glycan Therapeutics outside the submitted work; in addition, J. Liu has a patent to 421/434PCT/US pending. No other disclosures were reported.
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