Patients with Lung Cancer of Different Racial Backgrounds Harbor Distinct Immune Cell Profiles.
Journal
Cancer research communications
ISSN: 2767-9764
Titre abrégé: Cancer Res Commun
Pays: United States
ID NLM: 9918281580506676
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
received:
11
02
2022
revised:
23
06
2022
accepted:
04
08
2022
entrez:
16
3
2023
pubmed:
17
3
2023
medline:
17
3
2023
Statut:
epublish
Résumé
Tumors accumulated with infiltrated immune cells (hot tumors) have a higher response rate to immune checkpoint blockade, when compared with those with minimal T-cell infiltration (cold tumors). We report here that patients with lung cancer with different racial backgrounds harbored distinct immune cell profiles in the tumor microenvironment. Compared with African Americans (AA), Caucasian Americans (CA) exhibited increased immune cell infiltration and vasculature, and increased survival. Changes of survival and immune profile were most pronounced among active smokers and nonsmokers, compared with former smokers and total patients. Neighborhood analysis showed that immune cells accumulated around cancer cells in CAs but not AAs. Our findings reveal intrinsic biological differences between AA and CA patients with lung cancer, suggesting that treatment plans should be tailored for patients with different racial backgrounds. We report biological racial differences among patients with lung cancer where Caucasians present a hot tumor microenvironment compared with cold tumor in AAs. Treatment plans should be customized to maximize therapeutic outcomes.
Identifiants
pubmed: 36923308
doi: 10.1158/2767-9764.CRC-22-0057
pii: CRC-22-0057
pmc: PMC10010305
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
884-893Subventions
Organisme : NIEHS NIH HHS
ID : P30 ES030285
Pays : United States
Informations de copyright
© 2022 The Authors; Published by the American Association for Cancer Research.
Déclaration de conflit d'intérêts
K. Ramos reports grants from Houston Methodist Hospital and Texas A&M University during the conduct of the study; in addition, K. Ramos has a patent to 2019 62/787444 pending. No disclosures were reported by the other authors.
Références
Nat Protoc. 2016 Sep;11(9):1650-67
pubmed: 27560171
FASEB J. 2022 Apr;36(4):e22226
pubmed: 35233843
J Extracell Vesicles. 2019 Jul 23;8(1):1643214
pubmed: 31448067
Oncotarget. 2017 Oct 23;8(61):103828-103842
pubmed: 29262603
Oncogene. 2008 Sep 25;27(43):5741-52
pubmed: 18542056
CA Cancer J Clin. 2017 Nov;67(6):439-448
pubmed: 28972651
Redox Biol. 2019 Jul;25:101174
pubmed: 30917934
Respir Investig. 2018 Jan;56(1):28-33
pubmed: 29325677
Science. 1979 Dec 14;206(4424):1315-6
pubmed: 316188
Int J Radiat Oncol Biol Phys. 2021 Jun 1;110(2):492-506
pubmed: 32768562
J Immunother Cancer. 2018 Dec 27;6(1):157
pubmed: 30587233
Front Immunol. 2019 Sep 25;10:2215
pubmed: 31611871
Ann Am Thorac Soc. 2018 Dec;15(Suppl 4):S273-S277
pubmed: 30759018
Cell Metab. 2019 Apr 2;29(4):871-885.e5
pubmed: 30853213
Am J Cancer Res. 2016 May 01;6(5):1066-77
pubmed: 27293999
Trends Cancer. 2020 Jul;6(7):605-618
pubmed: 32610070
J Natl Cancer Inst. 2015 Mar 30;107(6):djv048
pubmed: 25825511
Adv Exp Med Biol. 2017;1036:19-31
pubmed: 29275462
J Vis Exp. 2020 Feb 1;(156):
pubmed: 32065171
Cell. 2010 Jun 25;141(7):1159-70
pubmed: 20602998
Nat Rev Clin Oncol. 2017 Jul;14(7):399-416
pubmed: 28117416
Cancers (Basel). 2021 May 28;13(11):
pubmed: 34071280
JAMA Oncol. 2017 Dec 1;3(12):1654-1662
pubmed: 28472234
Eur Respir J. 2010 Jun;35(6):1421-2
pubmed: 20513918
Appl Clin Genet. 2011 Jul 18;4:99-111
pubmed: 23776371
CA Cancer J Clin. 2019 May;69(3):211-233
pubmed: 30762872
Chest. 2004 Jan;125(1):15-21
pubmed: 14718415
Sci Transl Med. 2021 Dec 15;13(624):eabj5070
pubmed: 34910551
Nat Rev Cancer. 2012 Mar 15;12(4):298-306
pubmed: 22419253
Mech Ageing Dev. 2010 May;131(5):299-305
pubmed: 20346965
Mol Cancer. 2018 Feb 19;17(1):58
pubmed: 29455648
Proc Am Thorac Soc. 2008 Dec 1;5(8):811-5
pubmed: 19017734
Immunity. 2014 Jul 17;41(1):49-61
pubmed: 25035953
Am Soc Clin Oncol Educ Book. 2019 Jan;39:3-10
pubmed: 31099618
Proc Natl Acad Sci U S A. 2020 Jul 28;117(30):17965-17976
pubmed: 32651277
Genomics. 2007 Aug;90(2):176-85
pubmed: 17521869
Cell. 2010 Jun 25;141(7):1253-61
pubmed: 20603005
PLoS One. 2012;7(10):e47705
pubmed: 23077662
Mol Carcinog. 2020 Jul;59(7):852-861
pubmed: 32333615
Clin Cancer Res. 2017 Dec 1;23(23):7412-7425
pubmed: 29196495
Semin Cancer Biol. 2015 Dec;35 Suppl:S151-S184
pubmed: 25951989