Autoimmune Enteropathy: A Rare Cause of Chronic Diarrhea in an Adult Patient.
autoimmune enteropathy
chronic diarrhea
immunosuppression
malabsorption
Journal
ACG case reports journal
ISSN: 2326-3253
Titre abrégé: ACG Case Rep J
Pays: United States
ID NLM: 101638398
Informations de publication
Date de publication:
Mar 2023
Mar 2023
Historique:
received:
07
09
2022
accepted:
07
02
2023
entrez:
16
3
2023
pubmed:
17
3
2023
medline:
17
3
2023
Statut:
epublish
Résumé
Autoimmune enteropathy is a rare cause of malabsorption usually associated with circulating autoantibodies and predisposition to autoimmune disorders. The diagnosis is based on the following criteria: chronic diarrhea (>6 months), malabsorption, specific histological findings, anti-enterocyte and anti-goblet cell antibodies, and exclusion of similar disorders. We report a case of a 73-year-old woman presenting with severe chronic diarrhea, weight loss, and electrolyte abnormalities. Endoscopy revealed duodenal villous atrophy extending to proximal jejunum, and duodenal biopsies revealed villous blunting, cryptitis with apoptosis, and scattered intraepithelial lymphocytes. Therapeutic management included immunosuppressive treatment with corticosteroids, achieving clinical remission.
Identifiants
pubmed: 36923989
doi: 10.14309/crj.0000000000001009
pii: ACGCR-22-0595
pmc: PMC10010791
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e01009Informations de copyright
© 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology.
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