Protective Role of Cytochrome C Oxidase 5A (COX5A) against Mitochondrial Disorder and Oxidative Stress in VSMC Phenotypic Modulation and Neointima Formation.
Humans
Rats
Animals
Neointima
/ metabolism
Electron Transport Complex IV
/ metabolism
Muscle, Smooth, Vascular
Reactive Oxygen Species
/ metabolism
Hydrogen Peroxide
/ toxicity
Cells, Cultured
Becaplermin
/ metabolism
Cell Proliferation
Oxidative Stress
Myocytes, Smooth Muscle
Mitochondrial Diseases
/ metabolism
Adenosine Triphosphate
/ metabolism
Cell Movement
/ physiology
COX5A
VSMC phenotypic modulation
cytochrome c
intimal hyperplasia
mitochondrial respiratory chain
oxidative stress
Journal
Current vascular pharmacology
ISSN: 1875-6212
Titre abrégé: Curr Vasc Pharmacol
Pays: United Arab Emirates
ID NLM: 101157208
Informations de publication
Date de publication:
2023
2023
Historique:
received:
21
09
2022
revised:
12
12
2022
accepted:
26
01
2023
medline:
4
7
2023
pubmed:
17
3
2023
entrez:
16
3
2023
Statut:
ppublish
Résumé
The pathological role of cytochrome c oxidase 5A (COX5A) in vascular neointima formation remains unknown. This study aims to investigate the role of COX5A on platelet-derived growth factor BB (PDGFBB)- mediated smooth muscle phenotypic modulation and neointima formation and clarify the molecular mechanisms behind this effect. For The results showed that PDGF-BB reduced the level and altered the distribution of COX5A in mitochondria, as well as reduced complex IV activity, ATP synthesis, and OCR while increasing H The present study demonstrated that COX5A protects VSMCs against phenotypic modulation by improving mitochondrial respiratory function and attenuating mitochondrial damage, as well as reducing oxidative stress, thereby preventing neointima formation.
Sections du résumé
BACKGROUND
The pathological role of cytochrome c oxidase 5A (COX5A) in vascular neointima formation remains unknown.
AIM
This study aims to investigate the role of COX5A on platelet-derived growth factor BB (PDGFBB)- mediated smooth muscle phenotypic modulation and neointima formation and clarify the molecular mechanisms behind this effect.
METHODS
For
RESULTS
The results showed that PDGF-BB reduced the level and altered the distribution of COX5A in mitochondria, as well as reduced complex IV activity, ATP synthesis, and OCR while increasing H
CONCLUSION
The present study demonstrated that COX5A protects VSMCs against phenotypic modulation by improving mitochondrial respiratory function and attenuating mitochondrial damage, as well as reducing oxidative stress, thereby preventing neointima formation.
Identifiants
pubmed: 36924093
pii: CVP-EPUB-130169
doi: 10.2174/1570161121666230315142507
doi:
Substances chimiques
Electron Transport Complex IV
EC 1.9.3.1
Reactive Oxygen Species
0
Hydrogen Peroxide
BBX060AN9V
Becaplermin
1B56C968OA
Adenosine Triphosphate
8L70Q75FXE
COX5A protein, human
EC 1.9.3.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
128-142Informations de copyright
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.